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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32716

FusionGeneSummary for SBNO2_C1D

check button Fusion gene summary
Fusion gene informationFusion gene name: SBNO2_C1D
Fusion gene ID: 32716
HgeneTgene
Gene symbol

SBNO2

C1D

Gene ID

22904

10438

Gene namestrawberry notch homolog 2C1D nuclear receptor corepressor
SynonymsKIAA0963|SNO|STNOLRP1|Rrp47|SUN-CoR|SUNCOR|hC1D
Cytomap

19p13.3

2p14

Type of geneprotein-codingprotein-coding
Descriptionprotein strawberry notch homolog 2nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor
Modification date2018052320180519
UniProtAcc

Q9Y2G9

Q13901

Ensembl transtripts involved in fusion geneENST00000361757, ENST00000587024, 
ENST00000438103, 
ENST00000355848, 
ENST00000407324, ENST00000410067, 
ENST00000409302, ENST00000470189, 
Fusion gene scores* DoF score15 X 9 X 11=14854 X 3 X 3=36
# samples 174
** MAII scorelog2(17/1485*10)=-3.12685627955043
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SBNO2 [Title/Abstract] AND C1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSBNO2

GO:0071354

cellular response to interleukin-6

25903009


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N7-A59B-01ASBNO2chr19

1147308

-C1Dchr2

68274451

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361757ENST00000355848SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000361757ENST00000407324SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000361757ENST00000410067SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000361757ENST00000409302SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000361757ENST00000470189SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000587024ENST00000355848SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000587024ENST00000407324SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000587024ENST00000410067SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000587024ENST00000409302SBNO2chr19

1147308

-C1Dchr2

68274451

-
5CDS-5UTRENST00000587024ENST00000470189SBNO2chr19

1147308

-C1Dchr2

68274451

-
intron-5UTRENST00000438103ENST00000355848SBNO2chr19

1147308

-C1Dchr2

68274451

-
intron-5UTRENST00000438103ENST00000407324SBNO2chr19

1147308

-C1Dchr2

68274451

-
intron-5UTRENST00000438103ENST00000410067SBNO2chr19

1147308

-C1Dchr2

68274451

-
intron-5UTRENST00000438103ENST00000409302SBNO2chr19

1147308

-C1Dchr2

68274451

-
intron-5UTRENST00000438103ENST00000470189SBNO2chr19

1147308

-C1Dchr2

68274451

-

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FusionProtFeatures for SBNO2_C1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SBNO2

Q9Y2G9

C1D

Q13901

Acts as a transcriptional coregulator, that can haveboth coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of thetranscription factor MITF to the DC-STAMP promoter in osteoclast.Plays a role in bone homeostasis; required as a positive regulatorin TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation ofosteoblast differentiation (By similarity). Involved in thetranscriptional corepression of NF-kappaB in macrophages(PubMed:18025162). Plays a role as a regulator in theproinflammatory cascade (PubMed:18025162).{ECO:0000250|UniProtKB:Q7TNB8, ECO:0000269|PubMed:18025162}. Plays a role in the recruitment of the RNA exosomecomplex to pre-rRNA to mediate the 3'-5' end processing of the5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDCnot only in the presence of linear DNA but also in the presence ofsupercoiled DNA. Can induce apoptosis in a p53/TP53 dependentmanner. May regulate the TRAX/TSN complex formation. Potentiatestranscriptional repression by NR1D1 and THRB (By similarity).{ECO:0000250, ECO:0000269|PubMed:10362552,ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707,ECO:0000269|PubMed:9679063}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SBNO2_C1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SBNO2_C1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SBNO2TRIM25C1DPRKDC, TSNAX, PCBD2, APP, NCOR1, NCOR2, NR1D1, THRA, THRB, IL23R, EXOSC3, EXOSC7, EXOSC8, EXOSC9, EXOSC5, EXOSC1, EXOSC10, MPHOSPH6, EXOSC4, RBM7, EXOSC2, WDR43, ZFC3H1, UTP15, ZCCHC8, EXOSC6, DIS3, WDR75, SKIV2L2, CST1, NOL11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SBNO2_C1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SBNO2_C1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSBNO2C0036341Schizophrenia1PSYGENET
TgeneC1DC0001973Alcoholic Intoxication, Chronic1PSYGENET