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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32691

FusionGeneSummary for SBF1_TENM4

check button Fusion gene summary
Fusion gene informationFusion gene name: SBF1_TENM4
Fusion gene ID: 32691
HgeneTgene
Gene symbol

SBF1

TENM4

Gene ID

6305

26011

Gene nameSET binding factor 1teneurin transmembrane protein 4
SynonymsCMT4B3|DENND7A|MTMR5Doc4|ETM5|ODZ4|TNM4|Ten-M4|ten-4
Cytomap

22q13.33

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 5DENN/MADD domain containing 7Ateneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
Modification date2018051920180523
UniProtAcc

O95248

Q6N022

Ensembl transtripts involved in fusion geneENST00000380817, ENST00000348911, 
ENST00000390679, ENST00000476293, 
ENST00000278550, ENST00000533038, 
Fusion gene scores* DoF score5 X 5 X 5=12513 X 11 X 7=1001
# samples 513
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SBF1 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A1ZK-06ASBF1chr22

50905767

-TENM4chr11

78468066

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380817ENST00000278550SBF1chr22

50905767

-TENM4chr11

78468066

-
5CDS-intronENST00000380817ENST00000533038SBF1chr22

50905767

-TENM4chr11

78468066

-
Frame-shiftENST00000348911ENST00000278550SBF1chr22

50905767

-TENM4chr11

78468066

-
5CDS-intronENST00000348911ENST00000533038SBF1chr22

50905767

-TENM4chr11

78468066

-
Frame-shiftENST00000390679ENST00000278550SBF1chr22

50905767

-TENM4chr11

78468066

-
5CDS-intronENST00000390679ENST00000533038SBF1chr22

50905767

-TENM4chr11

78468066

-
intron-3CDSENST00000476293ENST00000278550SBF1chr22

50905767

-TENM4chr11

78468066

-
intron-intronENST00000476293ENST00000533038SBF1chr22

50905767

-TENM4chr11

78468066

-

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FusionProtFeatures for SBF1_TENM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SBF1

O95248

TENM4

Q6N022

Involved in neural development, regulating theestablishment of proper connectivity within the nervous system.Plays a role in the establishment of the anterior-posterior axisduring gastrulation. Regulates the differentiation and cellularprocess formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS)(PubMed:26188006). Promotes activation of focal adhesion kinase.May function as a cellular signal transducer (By similarity).{ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SBF1_TENM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SBF1_TENM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SBF1MTMR2, SUV39H1, PMS1, KMT2A, SIRT3, TNFSF11, PDPK1, SIRT7, CDKN1A, EFNB2, TGFBR2, SKAP1, GFOD1, C1orf186, HSPB1, FBXW11, NTRK1, COL1A2, MTMR1, PRKACA, RPAP3, SUPT16H, WDR55, SBF2, SBF1, UQCC1, UQCC2, RAB35, IFT27, CTTNBP2NL, STIP1, IFT52, MRPS16, PTGES3L, RAB6B, HAVCR2, SSSCA1, MANSC1, HENMT1, PIP4K2A, LRRC4C, CDH5, LZTS2, SELE, AATK, INO80BTENM4CAND1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SBF1_TENM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SBF1_TENM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSBF1C3695063CHARCOT-MARIE-TOOTH DISEASE, TYPE 4B31ORPHANET;UNIPROT
TgeneTENM4C0005586Bipolar Disorder1CTD_human
TgeneTENM4C0033975Psychotic Disorders1PSYGENET
TgeneTENM4C0036341Schizophrenia1PSYGENET
TgeneTENM4C0349204Nonorganic psychosis1PSYGENET
TgeneTENM4C4225223TREMOR, HEREDITARY ESSENTIAL, 51UNIPROT