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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32683

FusionGeneSummary for SATB2_SATB2

check button Fusion gene summary
Fusion gene informationFusion gene name: SATB2_SATB2
Fusion gene ID: 32683
HgeneTgene
Gene symbol

SATB2

SATB2

Gene ID

23314

23314

Gene nameSATB homeobox 2SATB homeobox 2
SynonymsGLSSGLSS
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein SATB2SATB family member 2special AT-rich sequence-binding protein 2DNA-binding protein SATB2SATB family member 2special AT-rich sequence-binding protein 2
Modification date2018052320180523
UniProtAcc

Q9UPW6

Q9UPW6

Ensembl transtripts involved in fusion geneENST00000417098, ENST00000443023, 
ENST00000260926, ENST00000428695, 
ENST00000457245, ENST00000484124, 
ENST00000417098, ENST00000443023, 
ENST00000260926, ENST00000428695, 
ENST00000457245, ENST00000484124, 
Fusion gene scores* DoF score2 X 3 X 1=63 X 4 X 3=36
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SATB2 [Title/Abstract] AND SATB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF756278SATB2chr2

200298239

+SATB2chr2

200233326

+
ChiTaRS3.1BE700169SATB2chr2

200173483

-SATB2chr2

200213899

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000417098ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000417098ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000417098ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000417098ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000417098ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000417098ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000443023ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000260926ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000428695ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000457245ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000417098SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000443023SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000260926SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000428695SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000457245SATB2chr2

200298239

+SATB2chr2

200233326

+
intron-intronENST00000484124ENST00000484124SATB2chr2

200298239

+SATB2chr2

200233326

+
Frame-shiftENST00000417098ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000417098ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000417098ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000417098ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000417098ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
5CDS-intronENST00000417098ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000443023ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000443023ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000443023ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000443023ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000443023ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
5CDS-intronENST00000443023ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000260926ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000260926ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000260926ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000260926ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000260926ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
5CDS-intronENST00000260926ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000428695ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000428695ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000428695ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000428695ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000428695ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
5CDS-intronENST00000428695ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000457245ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000457245ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000457245ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000457245ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
Frame-shiftENST00000457245ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
5CDS-intronENST00000457245ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-3CDSENST00000484124ENST00000417098SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-3CDSENST00000484124ENST00000443023SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-3CDSENST00000484124ENST00000260926SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-3CDSENST00000484124ENST00000428695SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-3CDSENST00000484124ENST00000457245SATB2chr2

200173483

-SATB2chr2

200213899

-
intron-intronENST00000484124ENST00000484124SATB2chr2

200173483

-SATB2chr2

200213899

-

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FusionProtFeatures for SATB2_SATB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SATB2

Q9UPW6

SATB2

Q9UPW6

Binds to DNA, at nuclear matrix- or scaffold-associatedregions. Thought to recognize the sugar-phosphate structure ofdouble-stranded DNA. Transcription factor controlling nuclear geneexpression, by binding to matrix attachment regions (MARs) of DNAand inducing a local chromatin-loop remodeling. Acts as a dockingsite for several chromatin remodeling enzymes and also byrecruiting corepressors (HDACs) or coactivators (HATs) directly topromoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for theinactivation of deep-layer neurons (DL) and UL2 specific genes,probably by modulating BCL11B expression. Repressor of Ctip2 andregulatory determinant of corticocortical connections in thedeveloping cerebral cortex. May play an important role in palateformation. Acts as a molecular node in a transcriptional networkregulating skeletal development and osteoblast differentiation.{ECO:0000269|PubMed:14701874}. Binds to DNA, at nuclear matrix- or scaffold-associatedregions. Thought to recognize the sugar-phosphate structure ofdouble-stranded DNA. Transcription factor controlling nuclear geneexpression, by binding to matrix attachment regions (MARs) of DNAand inducing a local chromatin-loop remodeling. Acts as a dockingsite for several chromatin remodeling enzymes and also byrecruiting corepressors (HDACs) or coactivators (HATs) directly topromoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for theinactivation of deep-layer neurons (DL) and UL2 specific genes,probably by modulating BCL11B expression. Repressor of Ctip2 andregulatory determinant of corticocortical connections in thedeveloping cerebral cortex. May play an important role in palateformation. Acts as a molecular node in a transcriptional networkregulating skeletal development and osteoblast differentiation.{ECO:0000269|PubMed:14701874}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SATB2_SATB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SATB2_SATB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SATB2MTA2, HDAC1, ELAVL1, RAB3IL1, MAGEA10, KLHL20, RFPL4B, QPRT, LHX6, JUN, RBPJ, TEAD2, FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD3, FOXE1, FOXF1, FOXG1, FOXI2, FOXJ2, FOXK2, FOXL1, FOXN1, FOXO1, FOXP1, FOXP3, FOXQ1, FOXS1, PCGF1, BCOR, NANOG, L3MBTL1, NCAPH2, MORF4L2, HSFY1, C6orf141, ASB3, CPNE5, PLK1, NR1D2SATB2MTA2, HDAC1, ELAVL1, RAB3IL1, MAGEA10, KLHL20, RFPL4B, QPRT, LHX6, JUN, RBPJ, TEAD2, FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD3, FOXE1, FOXF1, FOXG1, FOXI2, FOXJ2, FOXK2, FOXL1, FOXN1, FOXO1, FOXP1, FOXP3, FOXQ1, FOXS1, PCGF1, BCOR, NANOG, L3MBTL1, NCAPH2, MORF4L2, HSFY1, C6orf141, ASB3, CPNE5, PLK1, NR1D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SATB2_SATB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SATB2_SATB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSATB2C0008925Cleft Palate2CTD_human;HPO
HgeneSATB2C0007621Neoplastic Cell Transformation1CTD_human
HgeneSATB2C0149925Small cell carcinoma of lung1CTD_human
HgeneSATB2C0376634Craniofacial Abnormalities1CTD_human
TgeneSATB2C0008925Cleft Palate2CTD_human;HPO
TgeneSATB2C0007621Neoplastic Cell Transformation1CTD_human
TgeneSATB2C0149925Small cell carcinoma of lung1CTD_human
TgeneSATB2C0376634Craniofacial Abnormalities1CTD_human