|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32681 |
FusionGeneSummary for SATB1_STAC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SATB1_STAC | Fusion gene ID: 32681 | Hgene | Tgene | Gene symbol | SATB1 | STAC | Gene ID | 6304 | 6769 |
| Gene name | SATB homeobox 1 | SH3 and cysteine rich domain | |
| Synonyms | - | STAC1 | |
| Cytomap | 3p24.3 | 3p22.3-p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-binding protein SATB1special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA) | SH3 and cysteine-rich domain-containing proteinSRC homology 3 and cysteine-rich domain-containing protein | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q01826 | Q99469 | |
| Ensembl transtripts involved in fusion gene | ENST00000493952, ENST00000338745, ENST00000417717, ENST00000454909, ENST00000475083, | ENST00000273183, ENST00000457375, ENST00000476388, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SATB1 [Title/Abstract] AND STAC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7785-01A | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000493952 | ENST00000273183 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| intron-3CDS | ENST00000493952 | ENST00000457375 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| intron-3UTR | ENST00000493952 | ENST00000476388 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000338745 | ENST00000273183 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000338745 | ENST00000457375 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| 5CDS-3UTR | ENST00000338745 | ENST00000476388 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000417717 | ENST00000273183 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000417717 | ENST00000457375 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| 5CDS-3UTR | ENST00000417717 | ENST00000476388 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000454909 | ENST00000273183 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| Frame-shift | ENST00000454909 | ENST00000457375 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| 5CDS-3UTR | ENST00000454909 | ENST00000476388 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| intron-3CDS | ENST00000475083 | ENST00000273183 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| intron-3CDS | ENST00000475083 | ENST00000457375 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
| intron-3UTR | ENST00000475083 | ENST00000476388 | SATB1 | chr3 | 18419662 | - | STAC | chr3 | 36484856 | + |
Top |
FusionProtFeatures for SATB1_STAC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SATB1 | STAC |
| Crucial silencing factor contributing to the initiationof X inactivation mediated by Xist RNA that occurs duringembryogenesis and in lymphoma (By similarity). Binds to DNA atspecial AT-rich sequences, the consensus SATB1-binding sequence(CSBS), at nuclear matrix- or scaffold-associated regions. Thoughtto recognize the sugar-phosphate structure of double-stranded DNA.Transcriptional repressor controlling nuclear and viral geneexpression in a phosphorylated and acetylated status-dependentmanner, by binding to matrix attachment regions (MARs) of DNA andinducing a local chromatin-loop remodeling. Acts as a docking sitefor several chromatin remodeling enzymes (e.g. PML at the MHC-Ilocus) and also by recruiting corepressors (HDACs) or coactivators(HATs) directly to promoters and enhancers. Modulates genes thatare essential in the maturation of the immune T-cell CD8SP fromthymocytes. Required for the switching of fetal globin species,and beta- and gamma-globin genes regulation during erythroiddifferentiation. Plays a role in chromatin organization andnuclear architecture during apoptosis. Interacts with the uniqueregion (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seemspreferentially targeted by the HIV-1 integration machinery.Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2and IL2RA (interleukin) in T-cells by binding to the same domainthan HDAC1. Delineates specific epigenetic modifications at targetgene loci, directly up-regulating metastasis-associated geneswhile down-regulating tumor-suppressor genes. Reprograms chromatinorganization and the transcription profiles of breast tumors topromote growth and metastasis. {ECO:0000250,ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840,ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553,ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465,ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216,ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041,ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486,ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959,ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. | Promotes expression of the ion channel CACNA1H at thecell membrane, and thereby contributes to the regulation ofchannel activity. Plays a minor and redundant role in promotingthe expression of calcium channel CACNA1S at the cell membrane,and thereby contributes to increased channel activity. Slows downthe inactivation rate of the calcium channel CACNA1C.{ECO:0000250|UniProtKB:P97306}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SATB1_STAC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SATB1_STAC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SATB1 | UBE2I, SIN3A, HDAC1, HDAC2, BAZ1A, MTA2, SMARCA5, POLR2J, CUX1, CTBP1, PML, KAT2B, TAL1, UBR5, TOPORS, CBX4, PIAS1, PIAS3, PIAS4, CTNNB1, SIRT1, SUMO1, CASP6, SUMO1P1, EP300, QPRT, CHD3, JUN, RBPJ, TEAD2, FOXA1, FOXB1, FOXC1, FOXC2, FOXD3, FOXE1, FOXF1, FOXG1, FOXL1, FOXN1, FOXO1, FOXP1, FOXP3, FOXQ1, FOXS1, ZMIZ1, NFATC1, NFATC2, P4HA3 | STAC | NEDD4L, LMNA, C9orf156, TRIP6, NCKIPSD, LIMD1, APP, FBXO25, KANK2, LZTS2, KIAA1958, YWHAZ, FBXO11, ANKLE2, YWHAE, YWHAB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SATB1_STAC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SATB1_STAC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | STAC | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|