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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3266

FusionGeneSummary for ATP11B_FXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11B_FXR1
Fusion gene ID: 3266
HgeneTgene
Gene symbol

ATP11B

FXR1

Gene ID

23200

8087

Gene nameATPase phospholipid transporting 11B (putative)FMR1 autosomal homolog 1
SynonymsATPIF|ATPIRFXR1P
Cytomap

3q26.33

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B proteinfragile X mental retardation syndrome-related protein 1FXR1/MYC fusionfragile X mental retardation autosomal homolog variant p1Kfragile X mental retardation autosomal homolog variant p2Kfragile X mental retardation autosomal homolog variant p4Kfragil
Modification date2018052320180523
UniProtAcc

Q9Y2G3

P51114

Ensembl transtripts involved in fusion geneENST00000323116, ENST00000493826, 
ENST00000482794, 
ENST00000357559, 
ENST00000305586, ENST00000491674, 
ENST00000491062, ENST00000468861, 
ENST00000445140, ENST00000480918, 
Fusion gene scores* DoF score12 X 11 X 8=10565 X 5 X 3=75
# samples 125
** MAII scorelog2(12/1056*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP11B [Title/Abstract] AND FXR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFXR1

GO:2000637

positive regulation of gene silencing by miRNA

17057366


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-56-7823-01BATP11Bchr3

182511574

+FXR1chr3

180685839

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323116ENST00000357559ATP11Bchr3

182511574

+FXR1chr3

180685839

+
Frame-shiftENST00000323116ENST00000305586ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000323116ENST00000491674ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000323116ENST00000491062ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000323116ENST00000468861ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000323116ENST00000445140ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000323116ENST00000480918ATP11Bchr3

182511574

+FXR1chr3

180685839

+
Frame-shiftENST00000493826ENST00000357559ATP11Bchr3

182511574

+FXR1chr3

180685839

+
Frame-shiftENST00000493826ENST00000305586ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000493826ENST00000491674ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000493826ENST00000491062ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000493826ENST00000468861ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000493826ENST00000445140ATP11Bchr3

182511574

+FXR1chr3

180685839

+
5CDS-intronENST00000493826ENST00000480918ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-3CDSENST00000482794ENST00000357559ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-3CDSENST00000482794ENST00000305586ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-intronENST00000482794ENST00000491674ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-intronENST00000482794ENST00000491062ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-intronENST00000482794ENST00000468861ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-intronENST00000482794ENST00000445140ATP11Bchr3

182511574

+FXR1chr3

180685839

+
intron-intronENST00000482794ENST00000480918ATP11Bchr3

182511574

+FXR1chr3

180685839

+

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FusionProtFeatures for ATP11B_FXR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11B

Q9Y2G3

FXR1

P51114

Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). Involved in regulation of sensitivity tocisplatin; may contribute to secretory vesicle transport ofcisplatin from Golgi to plasma membrane.{ECO:0000269|PubMed:23585472, ECO:0000305}. RNA-binding protein required for embryonic and postnataldevelopment of muscle tissue. May regulate intracellular transportand local translation of certain mRNAs (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP11B_FXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP11B_FXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP11BTMEM30A, IFNA21FXR1FMR1, CYFIP2, CRMP1, GBP2, KIAA1377, C14orf1, LUC7L2, LRIF1, PRSS23, FXR2, CYFIP1, FXR1, GIGYF2, HDAC5, ELAVL1, SIRT7, TDRD3, CUL3, COPS5, CAND1, CSNK2A1, CAPRIN1, LRWD1, ORC2, RANBP9, TOP3B, UBAP2, CUL7, CCDC8, SUZ12, BMI1, WDR76, MAGEA4, PINX1, LUC7L, HSPB1, NTRK1, IFI16, CCNA2, CCNB1, CLU, CDK18, PRKCD, SNCA, TSNAX, BCLAF1, THOC1, NOP56, PLK2, CCDC93, UBA6, THOC2, SLAIN2, MYH7B, TUBA1C, CEP170P1, GLI1, FOXQ1, FOXS1, NFATC1, LGALS3BP, RRP8, PLEKHO1, ZNF512, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP11B_FXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP11B_FXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource