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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32658

FusionGeneSummary for SART3_GTF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: SART3_GTF3A
Fusion gene ID: 32658
HgeneTgene
Gene symbol

SART3

GTF3A

Gene ID

9733

2971

Gene namesquamous cell carcinoma antigen recognized by T cells 3general transcription factor IIIA
SynonymsDSAP1|P100|RP11-13G14|TIP110|p110|p110(nrb)AP2|TFIIIA
Cytomap

12q23.3

13q12.2

Type of geneprotein-codingprotein-coding
Descriptionsquamous cell carcinoma antigen recognized by T-cells 3HIV-1 Tat-interacting protein of 110kDaSART-3hSART-3p110 nuclear RNA-binding proteintat-interacting protein of 110 kDatranscription factor IIIA
Modification date2018052320180519
UniProtAcc

Q15020

Q92664

Ensembl transtripts involved in fusion geneENST00000228284, ENST00000431469, 
ENST00000552221, ENST00000546611, 
ENST00000381140, ENST00000470606, 
Fusion gene scores* DoF score5 X 7 X 4=1402 X 2 X 1=4
# samples 72
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: SART3 [Title/Abstract] AND GTF3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSART3

GO:0000244

spliceosomal tri-snRNP complex assembly

12032085|20595234

HgeneSART3

GO:0000387

spliceosomal snRNP assembly

14749385|15314151

HgeneSART3

GO:0000398

mRNA splicing, via spliceosome

15314151

HgeneSART3

GO:0006334

nucleosome assembly

24526689

HgeneSART3

GO:0010468

regulation of gene expression

21447833

HgeneSART3

GO:1903586

positive regulation of histone deubiquitination

24526689


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU686098SART3chr12

108916675

+GTF3Achr13

28004700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000228284ENST00000381140SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3UTRENST00000228284ENST00000470606SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3CDSENST00000431469ENST00000381140SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3UTRENST00000431469ENST00000470606SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3CDSENST00000552221ENST00000381140SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3UTRENST00000552221ENST00000470606SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3CDSENST00000546611ENST00000381140SART3chr12

108916675

+GTF3Achr13

28004700

+
intron-3UTRENST00000546611ENST00000470606SART3chr12

108916675

+GTF3Achr13

28004700

+

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FusionProtFeatures for SART3_GTF3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SART3

Q15020

GTF3A

Q92664

U6 snRNP-binding protein that functions as a recyclingfactor of the splicing machinery. Promotes the initial reassemblyof U4 and U6 snRNPs following their ejection from the spliceosomeduring its maturation (PubMed:12032085). Also binds U6atac snRNPsand may function as a recycling factor for U4atac/U6atacspliceosomal snRNP, an initial step in the assembly of U12-typespliceosomal complex. The U12-type spliceosomal complex plays arole in the splicing of introns with non-canonical splice sites(PubMed:14749385). May also function as a substrate-targetingfactor for deubiquitinases like USP4 and USP15. Recruits USP4 toubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex,promoting PRPF3 deubiquitination and thereby regulating thespliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly(PubMed:20595234). May also recruit the deubiquitinase USP15 tohistone H2B and mediate histone deubiquitination, therebyregulating gene expression and/or DNA repair (PubMed:24526689).May play a role in hematopoiesis probably through transcriptionregulation of specific genes including MYC (By similarity).{ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085,ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234,ECO:0000269|PubMed:24526689}. Regulates Tat transactivation activity through directinteraction. May be a cellular factor for HIV-1 gene expressionand viral replication. {ECO:0000269|PubMed:11959860}. Involved in ribosomal large subunit biogenesis. Bindsthe approximately 50 base pairs internal control region (ICR) of5S ribosomal RNA genes. It is required for their RNA polymeraseIII-dependent transcription and may also maintain thetranscription of other genes (PubMed:24120868). Also binds thetranscribed 5S RNA's (By similarity).{ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SART3_GTF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SART3_GTF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SART3_GTF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SART3_GTF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGTF3AC0019693HIV Infections1CTD_human