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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32652

FusionGeneSummary for SARS_MVD

check button Fusion gene summary
Fusion gene informationFusion gene name: SARS_MVD
Fusion gene ID: 32652
HgeneTgene
Gene symbol

SARS

MVD

Gene ID

54938

4597

Gene nameseryl-tRNA synthetase 2, mitochondrialmevalonate diphosphate decarboxylase
SynonymsSARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRSFP17780|MDDase|MPD|POROK7
Cytomap

19q13.2

16q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetasediphosphomevalonate decarboxylasemevalonate (diphospho) decarboxylasemevalonate pyrophosphate decarboxylase
Modification date2018052320180523
UniProtAcc

P49591

P53602

Ensembl transtripts involved in fusion geneENST00000234677, ENST00000369923, 
ENST00000468588, 
ENST00000301012, 
ENST00000568709, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 51
** MAII scorelog2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SARS [Title/Abstract] AND MVD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMVD

GO:0008299

isoprenoid biosynthetic process

11792727|14680974


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF958883SARSchr1

109780479

-MVDchr16

88719798

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000234677ENST00000301012SARSchr1

109780479

-MVDchr16

88719798

+
5CDS-intronENST00000234677ENST00000568709SARSchr1

109780479

-MVDchr16

88719798

+
In-frameENST00000369923ENST00000301012SARSchr1

109780479

-MVDchr16

88719798

+
5CDS-intronENST00000369923ENST00000568709SARSchr1

109780479

-MVDchr16

88719798

+
3UTR-3CDSENST00000468588ENST00000301012SARSchr1

109780479

-MVDchr16

88719798

+
3UTR-intronENST00000468588ENST00000568709SARSchr1

109780479

-MVDchr16

88719798

+

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FusionProtFeatures for SARS_MVD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SARS

P49591

MVD

P53602

Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}. Performs the first committed step in the biosynthesis ofisoprenes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SARS_MVD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0nt


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FusionGenePPI for SARS_MVD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SARS_MVD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SARS_MVD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMVDC3553549POROKERATOSIS 7, MULTIPLE TYPES2UNIPROT