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Fusion gene ID: 32652 |
FusionGeneSummary for SARS_MVD |
Fusion gene summary |
Fusion gene information | Fusion gene name: SARS_MVD | Fusion gene ID: 32652 | Hgene | Tgene | Gene symbol | SARS | MVD | Gene ID | 54938 | 4597 |
Gene name | seryl-tRNA synthetase 2, mitochondrial | mevalonate diphosphate decarboxylase | |
Synonyms | SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS | FP17780|MDDase|MPD|POROK7 | |
Cytomap | 19q13.2 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase | diphosphomevalonate decarboxylasemevalonate (diphospho) decarboxylasemevalonate pyrophosphate decarboxylase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P49591 | P53602 | |
Ensembl transtripts involved in fusion gene | ENST00000234677, ENST00000369923, ENST00000468588, | ENST00000301012, ENST00000568709, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SARS [Title/Abstract] AND MVD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MVD | GO:0008299 | isoprenoid biosynthetic process | 11792727|14680974 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF958883 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000234677 | ENST00000301012 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
5CDS-intron | ENST00000234677 | ENST00000568709 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
In-frame | ENST00000369923 | ENST00000301012 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
5CDS-intron | ENST00000369923 | ENST00000568709 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
3UTR-3CDS | ENST00000468588 | ENST00000301012 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
3UTR-intron | ENST00000468588 | ENST00000568709 | SARS | chr1 | 109780479 | - | MVD | chr16 | 88719798 | + |
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FusionProtFeatures for SARS_MVD |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SARS | MVD |
Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}. | Performs the first committed step in the biosynthesis ofisoprenes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SARS_MVD |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SARS_ENST00000369923_chr1_109780479_-_MVD_ENST00000301012_chr16_88719798_+_0nt |
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FusionGenePPI for SARS_MVD |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SARS_MVD |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SARS_MVD |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MVD | C3553549 | POROKERATOSIS 7, MULTIPLE TYPES | 2 | UNIPROT |