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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32649

FusionGeneSummary for SARS2_SIPA1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: SARS2_SIPA1L3
Fusion gene ID: 32649
HgeneTgene
Gene symbol

SARS2

SIPA1L3

Gene ID

54938

23094

Gene nameseryl-tRNA synthetase 2, mitochondrialsignal induced proliferation associated 1 like 3
SynonymsSARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRSCTRCT45|SPAL3|SPAR3
Cytomap

19q13.2

19q13.13-q13.2

Type of geneprotein-codingprotein-coding
Descriptionserine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetasesignal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3
Modification date2018052320180519
UniProtAcc

Q9NP81

O60292

Ensembl transtripts involved in fusion geneENST00000221431, ENST00000594171, 
ENST00000430193, ENST00000598831, 
ENST00000448145, ENST00000600042, 
ENST00000222345, ENST00000476317, 
Fusion gene scores* DoF score3 X 3 X 2=1815 X 10 X 9=1350
# samples 314
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/1350*10)=-3.26946067499323
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SARS2 [Title/Abstract] AND SIPA1L3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIPA1L3

GO:0003382

epithelial cell morphogenesis

26231217

TgeneSIPA1L3

GO:0090162

establishment of epithelial cell polarity

26231217


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-5X-AA5U-01ASARS2chr19

39416845

-SIPA1L3chr19

38519729

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000221431ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-3UTRENST00000221431ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5UTR-5UTRENST00000594171ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5UTR-3UTRENST00000594171ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-5UTRENST00000430193ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-3UTRENST00000430193ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
intron-5UTRENST00000598831ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
intron-3UTRENST00000598831ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-5UTRENST00000448145ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-3UTRENST00000448145ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-5UTRENST00000600042ENST00000222345SARS2chr19

39416845

-SIPA1L3chr19

38519729

+
5CDS-3UTRENST00000600042ENST00000476317SARS2chr19

39416845

-SIPA1L3chr19

38519729

+

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FusionProtFeatures for SARS2_SIPA1L3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SARS2

Q9NP81

SIPA1L3

O60292

Catalyzes the attachment of serine to tRNA(Ser). Is alsoprobably able to aminoacylate tRNA(Sec) with serine, to form themisacylated tRNA L-seryl-tRNA(Sec), which will be furtherconverted into selenocysteinyl-tRNA(Sec).{ECO:0000250|UniProtKB:Q9N0F3}. Plays a critical role in epithelial cell morphogenesis,polarity, adhesion and cytoskeletal organization in the lens(PubMed:26231217). {ECO:0000269|PubMed:26231217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SARS2_SIPA1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SARS2_SIPA1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SARS2PUF60, USP44, DMWD, ICT1, RAD21, CUL3, MTHFD1, ILF2, SPTAN1, ILF3, NENF, CALU, PRKCDBP, MATR3, TUFM, CDH2, PPT2, ESR1, FBXO17, KCMF1, UBE2A, UBE2B, HARS2, TARS, SBDS, NTRK1, NF2, CISD3, SPATA20, PPTC7, CHCHD2, NFATC1, BPNT1SIPA1L3SFN, ELAVL1, FMNL1, YWHAQ, DYRK1B, LATS2, YWHAB, WDR83, SRPK2, CEP152, CEP135, NINL, ODF2, RPGRIP1L, CAPZA2, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MYO19, MYO18A, CDH1, PTPRK, LZTS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SARS2_SIPA1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SARS2_SIPA1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSARS2C3151209HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROME1ORPHANET;UNIPROT