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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32615

FusionGeneSummary for SAP30BP_BEAN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SAP30BP_BEAN1
Fusion gene ID: 32615
HgeneTgene
Gene symbol

SAP30BP

BEAN1

Gene ID

29115

146227

Gene nameSAP30 binding proteinbrain expressed associated with NEDD4 1
SynonymsHCNGP|HTRG|HTRPBEAN|SCA31
Cytomap

17q25.1

16q21

Type of geneprotein-codingprotein-coding
DescriptionSAP30-binding proteinHSV-1 bindingtranscriptional regulator protein HCNGPprotein BEAN1brain-expressed protein associating with Nedd4 homolog
Modification date2018052320180519
UniProtAcc

Q9UHR5

Q3B7T3

Ensembl transtripts involved in fusion geneENST00000584667, ENST00000355423, 
ENST00000579864, 		ENST00000536005, 
ENST00000299694, ENST00000561796, 
ENST00000564819, ENST00000563075, 
Fusion gene scores* DoF score11 X 5 X 9=4952 X 2 X 1=4
# samples 175
** MAII scorelog2(17/495*10)=-1.54189377882927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/4*10)=3.64385618977473
Context

PubMed: SAP30BP [Title/Abstract] AND BEAN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSAP30BP

GO:0010942

positive regulation of cell death

15496587


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD624677SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
ChiTaRS3.1CD624676SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
ChiTaRS3.1CD624674SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
ChiTaRS3.1CD624673SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000584667ENST00000536005SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
5UTR-intronENST00000584667ENST00000299694SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
5UTR-intronENST00000584667ENST00000561796SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
5UTR-intronENST00000584667ENST00000564819SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
5UTR-intronENST00000584667ENST00000563075SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000355423ENST00000536005SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000355423ENST00000299694SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000355423ENST00000561796SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000355423ENST00000564819SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000355423ENST00000563075SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000579864ENST00000536005SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000579864ENST00000299694SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000579864ENST00000561796SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000579864ENST00000564819SAP30BPchr17

73663419

-BEAN1chr16

66526834

+
intron-intronENST00000579864ENST00000563075SAP30BPchr17

73663419

-BEAN1chr16

66526834

+

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FusionProtFeatures for SAP30BP_BEAN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SAP30BP

Q9UHR5

BEAN1

Q3B7T3

Induces cell death. May act as a transcriptionalcorepressor of a gene related to cell survival. May be involved inthe regulation of beta-2-microglobulin genes.{ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:15496587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SAP30BP_BEAN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SAP30BP_BEAN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SAP30BP_BEAN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SAP30BP_BEAN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSAP30BPC0036341Schizophrenia1CTD_human