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Fusion gene ID: 32608 |
FusionGeneSummary for SAMM50_PIP4K2C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAMM50_PIP4K2C | Fusion gene ID: 32608 | Hgene | Tgene | Gene symbol | SAMM50 | PIP4K2C | Gene ID | 25813 | 79837 |
| Gene name | SAMM50 sorting and assembly machinery component | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | |
| Synonyms | CGI-51|OMP85|SAM50|TOB55|TRG-3|YNL026W | PIP5K2C | |
| Cytomap | 22q13.31 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sorting and assembly machinery component 50 homologsorting and assembly machinery 50kDatransformation-related gene 3 protein | phosphatidylinositol 5-phosphate 4-kinase type-2 gammaPI(5)P 4-kinase type II gammaPIP4KII-gammaphosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 5-phosphate 4-kinase type II gammaphosphatidylinositol-4-phosphate 5-kinase, type II, gamma | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q9Y512 | Q8TBX8 | |
| Ensembl transtripts involved in fusion gene | ENST00000350028, ENST00000493161, ENST00000396202, | ENST00000422156, ENST00000540759, ENST00000550465, ENST00000354947, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 6 X 5=270 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SAMM50 [Title/Abstract] AND PIP4K2C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SAMM50 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2F-01A | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000350028 | ENST00000422156 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| In-frame | ENST00000350028 | ENST00000540759 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| In-frame | ENST00000350028 | ENST00000550465 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| In-frame | ENST00000350028 | ENST00000354947 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 3UTR-3CDS | ENST00000493161 | ENST00000422156 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 3UTR-3CDS | ENST00000493161 | ENST00000540759 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 3UTR-3CDS | ENST00000493161 | ENST00000550465 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 3UTR-3CDS | ENST00000493161 | ENST00000354947 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 5UTR-3CDS | ENST00000396202 | ENST00000422156 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 5UTR-3CDS | ENST00000396202 | ENST00000540759 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 5UTR-3CDS | ENST00000396202 | ENST00000550465 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
| 5UTR-3CDS | ENST00000396202 | ENST00000354947 | SAMM50 | chr22 | 44360433 | + | PIP4K2C | chr12 | 57987808 | + |
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FusionProtFeatures for SAMM50_PIP4K2C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAMM50 | PIP4K2C |
| Plays a crucial role in the maintenance of the structureof mitochondrial cristae and the proper assembly of themitochondrial respiratory chain complexes (PubMed:22252321,PubMed:25781180). Required for the assembly of TOMM40 into the TOMcomplex (PubMed:15644312). {ECO:0000269|PubMed:15644312,ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}. | May play an important role in the production ofPhosphatidylinositol bisphosphate (PIP2), in the endoplasmicreticulum. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SAMM50 | chr22:44360433 | chr12:57987808 | ENST00000350028 | + | 3 | 15 | 45_125 | 78 | 470 | Domain | POTRA |
| Tgene | PIP4K2C | chr22:44360433 | chr12:57987808 | ENST00000354947 | + | 0 | 10 | 43_420 | 58 | 422 | Domain | PIPK |
| Tgene | PIP4K2C | chr22:44360433 | chr12:57987808 | ENST00000422156 | + | 0 | 9 | 43_420 | 58 | 374 | Domain | PIPK |
| Tgene | PIP4K2C | chr22:44360433 | chr12:57987808 | ENST00000540759 | + | 0 | 11 | 43_420 | 58 | 831 | Domain | PIPK |
| Tgene | PIP4K2C | chr22:44360433 | chr12:57987808 | ENST00000550465 | + | 0 | 10 | 43_420 | 58 | 404 | Domain | PIPK |
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FusionGeneSequence for SAMM50_PIP4K2C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000422156_chr12_57987808_+_394aa MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEINELSQVPPPVM LLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFS HRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEE EAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHA >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000540759_chr12_57987808_+_442aa MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEINELSQVPPPVM LLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIA DMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQ KVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHR >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000550465_chr12_57987808_+_424aa MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEINELSQVPPPVM LLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHG NTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKR DVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRS >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000354947_chr12_57987808_+_442aa MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEINELSQVPPPVM LLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIA DMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQ KVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000422156_chr12_57987808_+_1182nt ATGGGGACTGTGCACGCCCGGAGTTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAA GTTGAGCCTGAAGCTAAACAGGAAATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGAT GATATCATCATTTGTGAAATTGGAGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATG CTGCTGCCAGATGACTTTAAGGCCAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTC AAGGAGTATTGTCCCCAGGTCTTCAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGTACATTGTGAAGTGCCATGGC AACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGAGTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGC CACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCC ACCCTTAAGGATATGGACTTTCTCAACAAGAACCAGAAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGA GATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGACTACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAG GAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCC CCAGAGGGTATCGGAGGCTACATCCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGT GCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATGGGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCA GCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTATGCTAAGCGATTCCTGGATTTTATTACCAAC >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000540759_chr12_57987808_+_1326nt ATGGGGACTGTGCACGCCCGGAGTTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAA GTTGAGCCTGAAGCTAAACAGGAAATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGAT GATATCATCATTTGTGAAATTGGAGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATG CTGCTGCCAGATGACTTTAAGGCCAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTC AAGGAGTATTGTCCCCAGGTCTTCAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGGTGTCCCTTACCCGAAACCCC CCCAGCGAAAGTGAAGGCAGTGATGGTCGCTTCCTTATCTCCTACGATCGGACTCTGGTCATCAAAGAAGTATCCAGTGAGGACATTGCT GACATGCATAGCAACCTCTCCAACTATCACCAGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGA GTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAG GGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCTCAACAAGAACCAG AAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGAC TACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGAT GGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACATCCATTCCCATCGG CCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATG GGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATC >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000550465_chr12_57987808_+_1272nt ATGGGGACTGTGCACGCCCGGAGTTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAA GTTGAGCCTGAAGCTAAACAGGAAATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGAT GATATCATCATTTGTGAAATTGGAGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATG CTGCTGCCAGATGACTTTAAGGCCAGCTCCAAGATCAAGGAGTATTGTCCCCAGGTCTTCAGGAACCTCCGTGATCGATTTGGCATTGAT GACCAAGATTACTTGGTGTCCCTTACCCGAAACCCCCCCAGCGAAAGTGAAGGCAGTGATGGTCGCTTCCTTATCTCCTACGATCGGACT CTGGTCATCAAAGAAGTATCCAGTGAGGACATTGCTGACATGCATAGCAACCTCTCCAACTATCACCAGTACATTGTGAAGTGCCATGGC AACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGAGTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGC CACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCC ACCCTTAAGGATATGGACTTTCTCAACAAGAACCAGAAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGA GATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGACTACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAG GAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCC CCAGAGGGTATCGGAGGCTACATCCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGT GCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATGGGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCA GCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTATGCTAAGCGATTCCTGGATTTTATTACCAAC >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000354947_chr12_57987808_+_1326nt ATGGGGACTGTGCACGCCCGGAGTTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAA GTTGAGCCTGAAGCTAAACAGGAAATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGAT GATATCATCATTTGTGAAATTGGAGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATG CTGCTGCCAGATGACTTTAAGGCCAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTC AAGGAGTATTGTCCCCAGGTCTTCAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGGTGTCCCTTACCCGAAACCCC CCCAGCGAAAGTGAAGGCAGTGATGGTCGCTTCCTTATCTCCTACGATCGGACTCTGGTCATCAAAGAAGTATCCAGTGAGGACATTGCT GACATGCATAGCAACCTCTCCAACTATCACCAGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGA GTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAG GGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCTCAACAAGAACCAG AAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGAC TACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGAT GGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACATCCATTCCCATCGG CCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATG GGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000422156_chr12_57987808_+_1659nt CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGAG TTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAAGTTGAGCCTGAAGCTAAACAGGA AATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGATGATATCATCATTTGTGAAATTGG AGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATGCTGCTGCCAGATGACTTTAAGGC CAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTCAAGGAGTATTGTCCCCAGGTCTT CAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCT GGGGATGTACCGAGTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAA GTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCT CAACAAGAACCAGAAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCT GAAGATCATGGACTACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGA GTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACAT CCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGA GGTCTACTTCATGGGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGC TGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTATGCTAAGCGATTCCTGGATTTTATTACCAACATCTTTGCCTAAGAGACTGCCTG GTTCTCTCTGATGTTCAAGGTGGTGGGGTTCTGAGACACTTGGGGGAATTGTGGGGATATTCTAGCCACCAGTTCTCTTCTTCCTTTGCT AAATTCAGGCTGCAGGCTCCTTCCATCCAGATAACTCCATCCTGTCGAGTAGGCTCTTTCTGACCCTCAGAAATACATTGTCCTTTTTCC TCTTTGCCCATTTTTCTTCCCTCTCTTCCTCCCCATGAGAAGTCTGCTTGTAGTATTAGAATGTTATTGTTGACTCTCTCCCAAGTGCCT >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000540759_chr12_57987808_+_3003nt CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGAG TTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAAGTTGAGCCTGAAGCTAAACAGGA AATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGATGATATCATCATTTGTGAAATTGG AGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATGCTGCTGCCAGATGACTTTAAGGC CAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTCAAGGAGTATTGTCCCCAGGTCTT CAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGGTGTCCCTTACCCGAAACCCCCCCAGCGAAAGTGAAGGCAGTGA TGGTCGCTTCCTTATCTCCTACGATCGGACTCTGGTCATCAAAGAAGTATCCAGTGAGGACATTGCTGACATGCATAGCAACCTCTCCAA CTATCACCAGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGAGTCAGTGTGGACAACGAAGACAG CTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGC CAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCTCAACAAGAACCAGAAAGTATATATTGGTGAAGAGGA GAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGACTACAGCCTTCTGCTAGGCATCCA CGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACC TCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACATCCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGA GTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATGGGCCTCATTGATATCCTTACACA GTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTA TGCTAAGCGATTCCTGGATTTTATTACCAACATCTTTGCCTAAGAGACTGCCTGGTTCTCTCTGATGTTCAAGGAGCTAGGGGAAGGGGG TTGTTTGCCTTCTTCAGGACCTGACTGGACAGATGGACCTGGCTCAAGCAACTACTCTGGATGCACTTTGCTGTGTGGGATGAACTAAAA GTGTCTGAATTTTGCTGATAACTTTATAAAACTCACTATGGCATGCTTCCCTCCTGGTGGGCCCTAGGATGGATGACACTCAAGATACTA CAGATGTGGGTGCAGGCATGCACACACACGATGGAATATGGCCATTCCTACACAGGTGGGGTAGAGAGTGGGTCAGCAGCCTGGCACCTC ACAGAGGTGGGACCTAAGAGGACTCATGATTATGCAGAGAATTGGATTGGGTCTCTGTCATAGATTGAGTAATCTCTTCCCTTACCTCAA TTCCATCTCCACCCATCTCTACATCTGGGCACAGCAACCCAGAGATGGCCAAAAGCATTCAAGCCTGGGGGAAGATGTTTGACTATTGCT GCTCTTCACCAGAACCTCACACCTCTCCTGGGACTGGAACCCTTCAGTGGGTGTGTGGCCAGTTTTGGAGGCTGGAATGATGGGCCAGGG TGTAGGATTCATTCTCCATGTAAAGTTTCCTTTCATCCTGCCTAGCCATCCCCAAGGTTTATTTCCAGAAGAAAGGAATATCTCTACTTG GATCAATTCTGGTCATTTCAAGAGGATGGAGGCCTCAAGTGTGGGAACTTCCCCTACTCCCTGGATGTGTGTACCTAGCACACTTCCTTC TCCCACCCCTTTTTCCAGTTGGATTTGTTTTTCTGTTCTCTTCTGTCCTGTCTTATACTGCAACTGTGTCTCCTAGGGGACAGATGGCCT TCTTTGTCATCTTCACTCTCCACCCCCAGAGAGGAGTCAGAGCCATAACTCAATCACTCAGCCCCTCCAAAGATAGTTGATGTGTGATAA TCTCATAATGTTGAGAACCCTGATGAGATACATTGTCTTCCTCTCCCTACAATGCCTCTGGGGCCAAGGCACCCATTCTTCTTGCTATCC TCCATCCCCCTTGAGGCTTCCACTTTTTTTTTTTTTAGACATAAAGCTGGGCATCAGCAACTGGCCTGTGGTGATGCAAAGCTGCTTTGC TCTGTATCTGGCTGGACTGATCTGTCTCACAAGAAGCCATGAGGCCATAGGGAGAAGCTCCCTCTCCCCTTCATCTTCTGCTCCAAAGGT GGTAGCAAGAGGAGTACCCAGTTAGGGGTTGGAGCCCCCATATAACATCTTCCTGTCAGAAGACTGATGGATCTTTTTCATTCCAACCAT CTCCCTTTCCCCCGATGAATGCAATAAAACTCTGTGACACCAGCAACCATTGCTCTTTAGAAATGGGTTTTCTGATCATATGGCTGATGT GTTATGGGCAGTATGGATGTCTTCATTTGTTGCTTCTGTTTTTCATCTTTTTTGTTTTATTAATAAAAATTTATGTATTTGCTCCTGTTA >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000550465_chr12_57987808_+_1702nt CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGAG TTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAAGTTGAGCCTGAAGCTAAACAGGA AATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGATGATATCATCATTTGTGAAATTGG AGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATGCTGCTGCCAGATGACTTTAAGGC CAGCTCCAAGATCAAGGAGTATTGTCCCCAGGTCTTCAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGGTGTCCCT TACCCGAAACCCCCCCAGCGAAAGTGAAGGCAGTGATGGTCGCTTCCTTATCTCCTACGATCGGACTCTGGTCATCAAAGAAGTATCCAG TGAGGACATTGCTGACATGCATAGCAACCTCTCCAACTATCACCAGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCT GGGGATGTACCGAGTCAGTGTGGACAACGAAGACAGCTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAA GTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGCCAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCT CAACAAGAACCAGAAAGTATATATTGGTGAAGAGGAGAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCT GAAGATCATGGACTACAGCCTTCTGCTAGGCATCCACGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGA GTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACCTCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACAT CCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGAGTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGA GGTCTACTTCATGGGCCTCATTGATATCCTTACACAGTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGC TGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTATGCTAAGCGATTCCTGGATTTTATTACCAACATCTTTGCCTAAGAGACTGCCTG GTTCTCTCTGATGTTCAAGGTGGTGGGGTTCTGAGACACTTGGGGGAATTGTGGGGATATTCTAGCCACCAGTTCTCTTCTTCCTTTGCT AAATTCAGGCTGCAGGCTCCTTCCATCCAGATAACTCCATCCTGTCGAGTAGGCTCTTTCTGACCCTCAGAAATACATTGTCCTTTTTCC >In-frame_SAMM50_ENST00000350028_chr22_44360433_+_PIP4K2C_ENST00000354947_chr12_57987808_+_3125nt CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGAG TTTGGAGCCTCTTCCATCAAGTGGACCTGATTTTGGAGGATTAGGAGAAGAAGCTGAATTTGTTGAAGTTGAGCCTGAAGCTAAACAGGA AATTCTTGAAAACAAAGATGTGGTTGTTCAACATGTTCATTTTGATGGACTTGGAAGGACTAAAGATGATATCATCATTTGTGAAATTGG AGATGTTTTCAAGGCCAAAAACCTAATTGAGATCAATGAGCTCAGCCAGGTGCCTCCCCCGGTGATGCTGCTGCCAGATGACTTTAAGGC CAGCTCCAAGATCAAGGTCAACAATCACCTTTTCCACAGGGAAAATCTGCCCAGTCATTTCAAGTTCAAGGAGTATTGTCCCCAGGTCTT CAGGAACCTCCGTGATCGATTTGGCATTGATGACCAAGATTACTTGGTGTCCCTTACCCGAAACCCCCCCAGCGAAAGTGAAGGCAGTGA TGGTCGCTTCCTTATCTCCTACGATCGGACTCTGGTCATCAAAGAAGTATCCAGTGAGGACATTGCTGACATGCATAGCAACCTCTCCAA CTATCACCAGTACATTGTGAAGTGCCATGGCAACACGCTTCTGCCCCAGTTCCTGGGGATGTACCGAGTCAGTGTGGACAACGAAGACAG CTACATGCTTGTGATGCGCAATATGTTTAGCCACCGTCTTCCTGTGCACAGGAAGTATGACCTCAAGGGTTCCCTAGTGTCCCGGGAAGC CAGCGATAAGGAAAAGGTTAAAGAATTGCCCACCCTTAAGGATATGGACTTTCTCAACAAGAACCAGAAAGTATATATTGGTGAAGAGGA GAAGAAAATATTTCTGGAGAAGCTGAAGAGAGATGTGGAGTTTCTAGTGCAGCTGAAGATCATGGACTACAGCCTTCTGCTAGGCATCCA CGACATCATTCGGGGCTCTGAACCAGAGGAGGAAGCGCCCGTGCGGGAGGATGAGTCAGAGGTGGATGGGGACTGCAGCCTGACTGGACC TCCTGCTCTTGTGGGCTCCTATGGCACCTCCCCAGAGGGTATCGGAGGCTACATCCATTCCCATCGGCCCCTGGGCCCAGGAGAGTTTGA GTCCTTCATTGATGTCTATGCCATCCGGAGTGCTGAAGGAGCCCCCCAGAAGGAGGTCTACTTCATGGGCCTCATTGATATCCTTACACA GTATGATGCTAAGAAGAAAGCAGCTCATGCAGCCAAAACTGTCAAGCATGGGGCTGGGGCAGAGATCTCTACTGTCCATCCGGAGCAGTA TGCTAAGCGATTCCTGGATTTTATTACCAACATCTTTGCCTAAGAGACTGCCTGGTTCTCTCTGATGTTCAAGGTGGTGGGGTTCTGAGA CACTTGGGGGAATTGTGGGGATATTCTAGCCACCAGTTCTCTTCTTCCTTTGCTAAATTCAGGCTGCAGGCTCCTTCCATCCAGATAACT CCATCCTGTCGAGTAGGCTCTTTCTGACCCTCAGAAATACATTGTCCTTTTTCCTCTTTGCCCATTTTTCTTCCCTCTCTTCCTCCCCAT GAGAAGTCTGCTTGTAGTATTAGAATGTTATTGTTGACTCTCTCCCAAGTGCCTTGATCTTTGTAATATCTCCTGTTGTTTCTATGATAT AGGAGCTAGGGGAAGGGGGTTGTTTGCCTTCTTCAGGACCTGACTGGACAGATGGACCTGGCTCAAGCAACTACTCTGGATGCACTTTGC TGTGTGGGATGAACTAAAAGTGTCTGAATTTTGCTGATAACTTTATAAAACTCACTATGGCATGCTTCCCTCCTGGTGGGCCCTAGGATG GATGACACTCAAGATACTACAGATGTGGGTGCAGGCATGCACACACACGATGGAATATGGCCATTCCTACACAGGTGGGGTAGAGAGTGG GTCAGCAGCCTGGCACCTCACAGAGGTGGGACCTAAGAGGACTCATGATTATGCAGAGAATTGGATTGGGTCTCTGTCATAGATTGAGTA ATCTCTTCCCTTACCTCAATTCCATCTCCACCCATCTCTACATCTGGGCACAGCAACCCAGAGATGGCCAAAAGCATTCAAGCCTGGGGG AAGATGTTTGACTATTGCTGCTCTTCACCAGAACCTCACACCTCTCCTGGGACTGGAACCCTTCAGTGGGTGTGTGGCCAGTTTTGGAGG CTGGAATGATGGGCCAGGGTGTAGGATTCATTCTCCATGTAAAGTTTCCTTTCATCCTGCCTAGCCATCCCCAAGGTTTATTTCCAGAAG AAAGGAATATCTCTACTTGGATCAATTCTGGTCATTTCAAGAGGATGGAGGCCTCAAGTGTGGGAACTTCCCCTACTCCCTGGATGTGTG TACCTAGCACACTTCCTTCTCCCACCCCTTTTTCCAGTTGGATTTGTTTTTCTGTTCTCTTCTGTCCTGTCTTATACTGCAACTGTGTCT CCTAGGGGACAGATGGCCTTCTTTGTCATCTTCACTCTCCACCCCCAGAGAGGAGTCAGAGCCATAACTCAATCACTCAGCCCCTCCAAA GATAGTTGATGTGTGATAATCTCATAATGTTGAGAACCCTGATGAGATACATTGTCTTCCTCTCCCTACAATGCCTCTGGGGCCAAGGCA CCCATTCTTCTTGCTATCCTCCATCCCCCTTGAGGCTTCCACTTTTTTTTTTTTTAGACATAAAGCTGGGCATCAGCAACTGGCCTGTGG TGATGCAAAGCTGCTTTGCTCTGTATCTGGCTGGACTGATCTGTCTCACAAGAAGCCATGAGGCCATAGGGAGAAGCTCCCTCTCCCCTT CATCTTCTGCTCCAAAGGTGGTAGCAAGAGGAGTACCCAGTTAGGGGTTGGAGCCCCCATATAACATCTTCCTGTCAGAAGACTGATGGA |
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FusionGenePPI for SAMM50_PIP4K2C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SAMM50 | MEOX2, MINOS1, TOMM22, NDUFS8, MRPL11, NDUFS3, SSBP1, SDHA, HSPA8, MRPS11, CYC1, SURF1, RPS23, NDUFB8, TOMM40, HNRNPM, SQRDL, SERINC1, HNRNPUL1, RHOT2, SLC25A17, CLN3, NPM1, CHCHD3, SUZ12, EGFR, TIMMDC1, MTX2, C19orf70, APOOL, C15orf48, NDUFA4, DUSP22, MTM1, RAB8A | PIP4K2C | ELAVL1, APP, PIP4K2C, FBXO25, CSNK2A2, ARL6IP4, EAF1, LZTS2, ZRANB2, EPB41L3, CSNK2A1, CSNK2B, DDX23, MTPN, MYL9, NCAPD3, PRPF8, SKP1, MED4, NF2, PIP4K2A, ARHGAP22, AHCYL2, GPBP1L1, PRICKLE3, HIF1AN, TULP3, ZNF428, CAMKV, POC1B, SUN2, TNFRSF19, C16orf71, GSPT2, APBA3, TNFRSF1A, HSD17B10 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SAMM50_PIP4K2C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SAMM50_PIP4K2C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PIP4K2C | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | PIP4K2C | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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