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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32588

FusionGeneSummary for SAMD4A_TIMM9

check button Fusion gene summary
Fusion gene informationFusion gene name: SAMD4A_TIMM9
Fusion gene ID: 32588
HgeneTgene
Gene symbol

SAMD4A

TIMM9

Gene ID

23034

26520

Gene namesterile alpha motif domain containing 4Atranslocase of inner mitochondrial membrane 9
SynonymsSAMD4|SMAUG|SMAUG1|SMG|SMGATIM9|TIM9A
Cytomap

14q22.2

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein Smaug homolog 1SAM domain-containing protein 4Amitochondrial import inner membrane translocase subunit Tim9translocase of inner mitochondrial membrane 9 homolog
Modification date2018052320180522
UniProtAcc

Q9UPU9

Q9Y5J7

Ensembl transtripts involved in fusion geneENST00000554335, ENST00000251091, 
ENST00000555112, ENST00000392067, 
ENST00000357634, ENST00000555192, 
ENST00000395159, ENST00000216463, 
ENST00000555593, ENST00000556007, 
ENST00000555061, ENST00000555404, 
Fusion gene scores* DoF score6 X 4 X 5=1203 X 2 X 3=18
# samples 73
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SAMD4A [Title/Abstract] AND TIMM9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSAMD4A

GO:0045727

positive regulation of translation

16221671

TgeneTIMM9

GO:0045039

protein import into mitochondrial inner membrane

16387659

TgeneTIMM9

GO:0072321

chaperone-mediated protein transport

16387659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-A4-7997-01ASAMD4Achr14

55034830

+TIMM9chr14

58878689

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000554335ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-intronENST00000554335ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000554335ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000554335ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000554335ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000554335ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000251091ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-intronENST00000251091ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000251091ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000251091ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000251091ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000251091ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-5UTRENST00000555112ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-intronENST00000555112ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-5UTRENST00000555112ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-5UTRENST00000555112ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-5UTRENST00000555112ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
3UTR-5UTRENST00000555112ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000392067ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-intronENST00000392067ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000392067ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000392067ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000392067ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000392067ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000357634ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-intronENST00000357634ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000357634ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000357634ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000357634ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
5CDS-5UTRENST00000357634ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-5UTRENST00000555192ENST00000395159SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-intronENST00000555192ENST00000216463SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-5UTRENST00000555192ENST00000555593SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-5UTRENST00000555192ENST00000556007SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-5UTRENST00000555192ENST00000555061SAMD4Achr14

55034830

+TIMM9chr14

58878689

-
intron-5UTRENST00000555192ENST00000555404SAMD4Achr14

55034830

+TIMM9chr14

58878689

-

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FusionProtFeatures for SAMD4A_TIMM9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SAMD4A

Q9UPU9

TIMM9

Q9Y5J7

Acts as a translational repressor of SRE-containingmessengers. {ECO:0000269|PubMed:16221671}. Mitochondrial intermembrane chaperone that participatesin the import and insertion of multi-pass transmembrane proteinsinto the mitochondrial inner membrane. May also be required forthe transfer of beta-barrel precursors from the TOM complex to thesorting and assembly machinery (SAM complex) of the outermembrane. Acts as a chaperone-like protein that protects thehydrophobic precursors from aggregation and guide them through themitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SAMD4A_TIMM9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SAMD4A_TIMM9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SAMD4AYWHAG, YWHAB, GOLGA2, NUTM1, XPO1, SAMD4B, INPPL1, TNIP1, YWHAZ, YWHAE, DDB2, YWHAH, CSDE1, GAN, PDP1, TRIM25TIMM9TIMM10, PRDX6, NADK2, NIT2, HTRA2, SLC25A6, UQCRFS1, NDUFV1, MPST, THOP1, OXCT1, SART1, DHX9, SFPQ, HNRNPM, SEC22B, ATF2, BAG3, COX5A, NUDC, PTGES3, TIMM13, TIMM8A, TIMM8B, CTSA, ANKS6, C19orf52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SAMD4A_TIMM9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SAMD4A_TIMM9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSAMD4AC0236969Substance-Related Disorders1CTD_human