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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32587

FusionGeneSummary for SAMD4A_SAMD4A

check button Fusion gene summary
Fusion gene informationFusion gene name: SAMD4A_SAMD4A
Fusion gene ID: 32587
HgeneTgene
Gene symbol

SAMD4A

SAMD4A

Gene ID

23034

23034

Gene namesterile alpha motif domain containing 4Asterile alpha motif domain containing 4A
SynonymsSAMD4|SMAUG|SMAUG1|SMG|SMGASAMD4|SMAUG|SMAUG1|SMG|SMGA
Cytomap

14q22.2

14q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein Smaug homolog 1SAM domain-containing protein 4Aprotein Smaug homolog 1SAM domain-containing protein 4A
Modification date2018052320180523
UniProtAcc

Q9UPU9

Q9UPU9

Ensembl transtripts involved in fusion geneENST00000554335, ENST00000251091, 
ENST00000555112, ENST00000392067, 
ENST00000357634, ENST00000555192, 
ENST00000554335, ENST00000251091, 
ENST00000555112, ENST00000392067, 
ENST00000357634, ENST00000555192, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 5 X 3=75
# samples 77
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SAMD4A [Title/Abstract] AND SAMD4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSAMD4A

GO:0045727

positive regulation of translation

16221671

TgeneSAMD4A

GO:0045727

positive regulation of translation

16221671


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC011489SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
ChiTaRS3.1BF344193SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000554335ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000554335ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000554335ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000554335ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000554335ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000554335ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000251091ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000251091ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000251091ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000251091ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000251091ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000251091ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555112ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555112ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555112ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555112ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555112ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555112ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000392067ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000392067ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000392067ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000392067ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000392067ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000392067ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000357634ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000357634ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000357634ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000357634ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-3UTRENST00000357634ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
3UTR-intronENST00000357634ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555192ENST00000554335SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555192ENST00000251091SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555192ENST00000555112SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555192ENST00000392067SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-3UTRENST00000555192ENST00000357634SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+
intron-intronENST00000555192ENST00000555192SAMD4Achr14

55258668

-SAMD4Achr14

55258824

+

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FusionProtFeatures for SAMD4A_SAMD4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SAMD4A

Q9UPU9

SAMD4A

Q9UPU9

Acts as a translational repressor of SRE-containingmessengers. {ECO:0000269|PubMed:16221671}. Acts as a translational repressor of SRE-containingmessengers. {ECO:0000269|PubMed:16221671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SAMD4A_SAMD4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SAMD4A_SAMD4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SAMD4A_SAMD4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SAMD4A_SAMD4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSAMD4AC0236969Substance-Related Disorders1CTD_human
TgeneSAMD4AC0236969Substance-Related Disorders1CTD_human