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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32555

FusionGeneSummary for SAFB_ARRDC5

check button Fusion gene summary
Fusion gene informationFusion gene name: SAFB_ARRDC5
Fusion gene ID: 32555
HgeneTgene
Gene symbol

SAFB

ARRDC5

Gene ID

6294

645432

Gene namescaffold attachment factor Barrestin domain containing 5
SynonymsHAP|HET|SAB-B1|SAF-B|SAF-B1|SAFB1-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionscaffold attachment factor B1HSP27 ERE-TATA-binding proteinHSP27 estrogen response element-TATA box-binding proteinHsp27 ERE-TATA binding proteinglutathione S-transferase fusion proteinheat-shock protein (HSP27) estrogen response element and TATA boxarrestin domain-containing protein 5
Modification date2018052320180519
UniProtAcc

Q15424

A6NEK1

Ensembl transtripts involved in fusion geneENST00000292123, ENST00000592224, 
ENST00000586934, ENST00000454510, 
ENST00000433404, ENST00000588852, 
ENST00000538656, 
ENST00000381781, 
Fusion gene scores* DoF score6 X 6 X 4=1443 X 2 X 3=18
# samples 73
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SAFB [Title/Abstract] AND ARRDC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01ASAFBchr19

5645410

+ARRDC5chr19

4891585

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000292123ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
Frame-shiftENST00000592224ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
3UTR-3CDSENST00000586934ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
Frame-shiftENST00000454510ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
Frame-shiftENST00000433404ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
Frame-shiftENST00000588852ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-
Frame-shiftENST00000538656ENST00000381781SAFBchr19

5645410

+ARRDC5chr19

4891585

-

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FusionProtFeatures for SAFB_ARRDC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SAFB

Q15424

ARRDC5

A6NEK1

Binds to scaffold/matrix attachment region (S/MAR) DNAand forms a molecular assembly point to allow the formation of a'transcriptosomal' complex (consisting of SR proteins and RNApolymerase II) coupling transcription and RNA processing (Bysimilarity). Can function as an estrogen receptor corepressor andcan also bind to the HSP27 promoter and decrease itstranscription. When associated with RBMX, binds to and stimulatestranscription from the SREBF1 promoter (By similarity). Caninhibit cell proliferation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SAFB_ARRDC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SAFB_ARRDC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SAFBSAFB2, ABHD16A, TAF15, ESR1, CHD1, CLK1, CHD3, HNRNPD, HNRNPA1, USP45, KHDRBS2, RB1CC1, NCOR1, HDAC3, SRRM1, MAP1LC3B, CDC37, PIAS1, SREK1, ELAVL1, TCF3, CUL3, SAP18, SMU1, TPBG, TRIM55, U2AF1, RBMX, SON, TRMT112, SEPT7, UTP14A, VTN, ZC3H18, USP39, TMOD2, VASN, SRSF7, LAMP2, EPPK1, PRKAR1A, CORO1B, GCN1L1, AK2, CPSF6, NCSTN, ACAT1, U2AF2, ACIN1, ABCC1, SURF4, DYNLRB1, TP53BP1, CSNK2A1, TP63, IL7R, MAP1LC3A, LGR4, STAU1, CUL7, OBSL1, EED, SRPK1, TP53, ABCE1, ZFP41, UNK, NTRK1, HNRNPU, HNRNPUL1, MCM4, P4HB, SF3B6, EWSR1, SRPK2, PPP1CB, MATR3, MPHOSPH8, ELAVL2, CAPN13, APOBEC3D, CDK1, COQ2, COX15, DLST, DNM1L, PDHA1, VDAC1, FOXA1ARRDC5HSPB1, ERRFI1, PDCD5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SAFB_ARRDC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SAFB_ARRDC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource