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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32510

FusionGeneSummary for S100A8_TNNT1

check button Fusion gene summary
Fusion gene informationFusion gene name: S100A8_TNNT1
Fusion gene ID: 32510
HgeneTgene
Gene symbol

S100A8

TNNT1

Gene ID

6279

7138

Gene nameS100 calcium binding protein A8troponin T1, slow skeletal type
Synonyms60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8ANM|NEM5|STNT|TNT|TNTS
Cytomap

1q21.3

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-A8calgranulin Acalprotectin L1L subunitcystic fibrosis antigenleukocyte L1 complex light chainmigration inhibitory factor-related protein 8urinary stone protein band Atroponin T, slow skeletal muscleslow skeletal muscle troponin Ttroponin T type 1 (skeletal, slow)troponin-T1, skeletal, slow
Modification date2018052220180523
UniProtAcc

P05109

P13805

Ensembl transtripts involved in fusion geneENST00000368732, ENST00000368733, 
ENST00000477801, 
ENST00000587758, 
ENST00000588426, ENST00000356783, 
ENST00000291901, ENST00000536926, 
ENST00000588981, ENST00000587465, 
ENST00000585321, ENST00000592920, 
Fusion gene scores* DoF score7 X 5 X 4=1407 X 4 X 5=140
# samples 97
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: S100A8 [Title/Abstract] AND TNNT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneS100A8

GO:0002523

leukocyte migration involved in inflammatory response

12626582

HgeneS100A8

GO:0006914

autophagy

19935772

HgeneS100A8

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

19935772

HgeneS100A8

GO:0030593

neutrophil chemotaxis

12626582

HgeneS100A8

GO:0050729

positive regulation of inflammatory response

12626582

HgeneS100A8

GO:0070488

neutrophil aggregation

12626582

HgeneS100A8

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

19935772

TgeneTNNT1

GO:0045932

negative regulation of muscle contraction

18032382


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-IG-A5B8-01AS100A8chr1

153362508

-TNNT1chr19

55646910

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368732ENST00000587758S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000588426S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000356783S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000291901S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000536926S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000588981S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000587465S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000585321S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368732ENST00000592920S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000587758S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000588426S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000356783S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000291901S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000536926S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000588981S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000587465S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000585321S100A8chr1

153362508

-TNNT1chr19

55646910

-
5CDS-intronENST00000368733ENST00000592920S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000587758S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000588426S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000356783S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000291901S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000536926S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000588981S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000587465S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000585321S100A8chr1

153362508

-TNNT1chr19

55646910

-
intron-intronENST00000477801ENST00000592920S100A8chr1

153362508

-TNNT1chr19

55646910

-

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FusionProtFeatures for S100A8_TNNT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100A8

P05109

TNNT1

P13805

S100A8 is a calcium- and zinc-binding protein whichplays a prominent role in the regulation of inflammatory processesand immune response. It can induce neutrophil chemotaxis andadhesion. Predominantly found as calprotectin (S100A8/A9) whichhas a wide plethora of intra- and extracellular functions. Theintracellular functions include: facilitating leukocytearachidonic acid trafficking and metabolism, modulation of thetubulin-dependent cytoskeleton during migration of phagocytes andactivation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cellmembrane, transferring arachidonic acid, an essential cofactor, tothe enzyme complex and S100A8 contributes to the enzyme assemblyby directly binding to NCF2/P67PHOX. The extracellular functionsinvolve proinflammatory, antimicrobial, oxidant-scavenging andapoptosis-inducing activities. Its proinflammatory activityincludes recruitment of leukocytes, promotion of cytokine andchemokine production, and regulation of leukocyte adhesion andmigration. Acts as an alarmin or a danger associated molecularpattern (DAMP) molecule and stimulates innate immune cells viabinding to pattern recognition receptors such as Toll-likereceptor 4 (TLR4) and receptor for advanced glycation endproducts(AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of theproinflammatory cascade. Has antimicrobial activity towardsbacteria and fungi and exerts its antimicrobial activity probablyvia chelation of Zn(2+) which is essential for microbial growth.Can induce cell death via autophagy and apoptosis and this occursthrough the cross-talk of mitochondria and lysosomes via reactiveoxygen species (ROS) and the process involves BNIP3. Can regulateneutrophil number and apoptosis by an anti-apoptotic effect;regulates cell survival via ITGAM/ITGB and TLR4 and a signalingmechanism involving MEK-ERK. Its role as an oxidant scavenger hasa protective role in preventing exaggerated tissue damage byscavenging oxidants. Can act as a potent amplifier of inflammationin autoimmunity as well as in cancer development and tumor spread.The iNOS-S100A8/A9 transnitrosylase complex directs selectiveinflammatory stimulus-dependent S-nitrosylation of GAPDH andprobably multiple targets such as ANXA5, EZR, MSN and VIM byrecognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contributeto S-nitrosylation site selectivity. {ECO:0000269|PubMed:12626582,ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15598812,ECO:0000269|PubMed:15642721, ECO:0000269|PubMed:16258195,ECO:0000269|PubMed:19087201, ECO:0000269|PubMed:19122197,ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:21487906,ECO:0000269|PubMed:22363402, ECO:0000269|PubMed:22808130,ECO:0000269|PubMed:25417112}. Troponin T is the tropomyosin-binding subunit oftroponin, the thin filament regulatory complex which conferscalcium-sensitivity to striated muscle actomyosin ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for S100A8_TNNT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for S100A8_TNNT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
S100A8MOB1A, LRRK1, PPM1B, NUAK1, ASB3, USF2, C14orf1, PRMT1, PDCD11, PPIA, CHGB, GDF9, IGSF21, TP53, LRIF1, UNC119, S100A8, DMWD, SLX1B, S100A9, TERF1, TERF2, POT1, CDKN1A, SIRT7, TFAP4, CDK2, COPS5, SHC1, APP, ESR1, PAXIP1, TRAF3IP1, BAG3, BECN1, UBASH3B, TUBGCP3, NCF2, SIRT6, PTEN, MCM2, MCM5, NF2, GRB2, TUBB, TUBA1A, SMTNL2, TBC1D22B, DPH6, EFHD1, CCNYL1, CYLD, DLD, TRIM25TNNT1TNNC1, CCDC85B, PLEKHF1, PPFIA1, TNNT1, ZMYND19, PSMC5, NINL, FXR2, TPM1, PRKG1, TRIM63, IMMT, SH3GL3, ZNF768, KAT5, PI4KA, NACAD, EEF1G, HMGXB4, BLOC1S2, SNW1, ZC3H15, HMP19, SERPINA4, UBE2D1, ZNF250, ZKSCAN5, NAGK, OSM, OSBP2, HSP90AB1, TRA2A, TMEM98, MARS, VIM, HAP1, ARMC8, SEC31A, FYN, C2orf44, CHD3, DDX5, FAF1, LARP1, NFE2L2, TPM3, TBPL1, MORF4L1, LDOC1, TFIP11, CCDC136, KRT40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for S100A8_TNNT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100A8P05109DB01593ZincProtein S100-A8small moleculeapproved|investigational
HgeneS100A8P05109DB01373CalciumProtein S100-A8small moleculeapproved|nutraceutical

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RelatedDiseases for S100A8_TNNT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneS100A8C0011615Dermatitis, Atopic1CTD_human
HgeneS100A8C0011616Contact Dermatitis1CTD_human
HgeneS100A8C0022548Keloid1CTD_human
HgeneS100A8C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneS100A8C0024667Animal Mammary Neoplasms1CTD_human