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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 325

FusionGeneSummary for ACACA_TADA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA_TADA2A
Fusion gene ID: 325
HgeneTgene
Gene symbol

ACACA

TADA2A

Gene ID

31

6871

Gene nameacetyl-CoA carboxylase alphatranscriptional adaptor 2A
SynonymsACAC|ACACAD|ACC|ACC1|ACCAADA2|ADA2A|KL04P|TADA2L|hADA2
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphatranscriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alpha
Modification date2018052220180523
UniProtAcc

Q13085

O75478

Ensembl transtripts involved in fusion geneENST00000353139, ENST00000360679, 
ENST00000394406, ENST00000335166, 
ENST00000416895, ENST00000361253, 
ENST00000588142, ENST00000589665, 
ENST00000394395, ENST00000586023, 
ENST00000225396, ENST00000417170, 
ENST00000591992, 
Fusion gene scores* DoF score23 X 13 X 11=32897 X 5 X 3=105
# samples 217
** MAII scorelog2(21/3289*10)=-3.96918777516928
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACACA [Title/Abstract] AND TADA2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTADA2A

GO:0043966

histone H3 acetylation

9674425


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A2I2-01AACACAchr17

35766352

-TADA2Achr17

35783609

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000353139ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
Frame-shiftENST00000353139ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
Frame-shiftENST00000353139ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
Frame-shiftENST00000353139ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
5CDS-intronENST00000353139ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000360679ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000360679ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000360679ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000360679ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-intronENST00000360679ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000394406ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000394406ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000394406ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000394406ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-intronENST00000394406ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000335166ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000335166ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000335166ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000335166ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-intronENST00000335166ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000416895ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000416895ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000416895ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000416895ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-intronENST00000416895ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000361253ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000361253ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000361253ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000361253ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-intronENST00000361253ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000588142ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000588142ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000588142ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-3CDSENST00000588142ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
intron-intronENST00000588142ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000589665ENST00000394395ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000589665ENST00000586023ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000589665ENST00000225396ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-3CDSENST00000589665ENST00000417170ACACAchr17

35766352

-TADA2Achr17

35783609

+
5UTR-intronENST00000589665ENST00000591992ACACAchr17

35766352

-TADA2Achr17

35783609

+

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FusionProtFeatures for ACACA_TADA2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

TADA2A

O75478

Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4. Required for thefunction of some acidic activation domains, which activatetranscription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker regionbetween neighboring nucleosomes. Plays a role in chromatinremodeling. May promote TP53/p53 'Lys-321' acetylation, leading toreduced TP53 stability and transcriptional activity(PubMed:22644376). May also promote XRCC6 acetylation thusfacilitating cell apoptosis in response to DNA damage(PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6,ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACACA_TADA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACACA_TADA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACACABRCA1, CHGB, PRKAA2, MLLT3, MLLT1, NPM1, AKR1B10, SIRT1, ARRB1, SIRT7, UBE2N, ATXN1, INPPL1, CBL, UBASH3B, PIK3R2, SHC1, AP2M1, ERCC6L, IKBKAP, CA9, VCP, FN1, IFIT1, FBXO6, CCT3, COPB1, DCAF6, EPB41L1, KIF5B, NUP50, PSMB7, SMEK1, EEF2K, STK25, PHKG2, ADRBK1, CSNK1A1, CSNK1E, PRKAA1, STK3, ILK, RPS6KA1, RIOK2, PRKAB1, PRKAG1, FUS, ENO1, MOV10, NXF1, MDM2, SUZ12, RNF2, BMI1, EGFR, SOCS6, SGCZ, C20orf195, PSG1, ARHGAP25, LIPH, IARS, PSMB2, PSMC6, PSMD2, NTRK1, PTEN, NDUFA4, C15orf48, COQ9, ZNF746, OAS2, LGALS3BP, C4orf26, TRIM25TADA2AEXOC8, FAM107A, HGS, TADA3, MYC, NR3C1, KAT2A, ATXN7, TP53, CTNNB1, KAT2B, MED1, MED26, CCDC101, ERCC4, CDK8, SRSF1, DDX3X, LUC7L, RNF41, DHX16, DDB1, MED29, TRIM28, SNRPA, SSB, NCBP1, PRPF6, CDC40, SRSF3, WDTC1, RBM39, MED30, MED28, PSPC1, TRA2B, TRA2A, RALY, NONO, PRRC2B, PLRG1, HELT, SRSF4, XAB2, MED8, PUF60, MED25, DHX15, RNPS1, SRSF5, EIF3H, SRRM1, LRCH4, MYEF2, RBM14, EIF3I, MED20, EIF3C, EIF3M, SIN3A, EIF3B, EIF3L, PRPF19, HNRNPC, ILF3, CDC5L, AKAP8, MED18, SNW1, HDAC1, MARK3, PABPC1P1, C11orf30, KRT8, POLR2A, SRRM2, MED16, ILF2, HSPA5, MED14, MED31, LUC7L3, DDX5, MED4, SFPQ, MED15, MED17, DDX17, POLR2B, WDR5, HNRNPF, ACTC1, DOCK6, LUZP1, MED27, POLR2C, HNRNPM, MARK2, MED22, MED23, ZZZ3, MED6, MED12, MED13, YEATS2, DR1, MBIP, SUPT3H, TCF3, PAXIP1, HSP90AA1, HNF4A, LYN, MCPH1, USP22, ARNT2, PRKAB2, KPNA2, MAGOH, MFAP1, EIF4E2, MTX2, FARS2, SF3A3, ZFYVE26, PPP1R16B, PRPF31, CCHCR1, C1orf109, CDCA7L, GPSM3, TTC23, FBF1, KLC4, LOC149950, TEKT4, ZNF564, TTC9C, KLHL38, FAM127C, PSME3, CARD8, PSMC3, IKZF5, CDH19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACACA_TADA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACACAQ13085DB00121BiotinAcetyl-CoA carboxylase 1small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for ACACA_TADA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACACAC0018801Heart failure1CTD_human
HgeneACACAC2239176Liver carcinoma1CTD_human