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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32485

FusionGeneSummary for S100A2_RPL30

check button Fusion gene summary
Fusion gene informationFusion gene name: S100A2_RPL30
Fusion gene ID: 32485
HgeneTgene
Gene symbol

S100A2

RPL30

Gene ID

6273

6156

Gene nameS100 calcium binding protein A2ribosomal protein L30
SynonymsCAN19|S100LL30
Cytomap

1q21.3

8q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-A260S ribosomal protein L30large ribosomal subunit protein eL30
Modification date2018051920180523
UniProtAcc

P29034

P62888

Ensembl transtripts involved in fusion geneENST00000368708, ENST00000487430, 
ENST00000497140, ENST00000368710, 
ENST00000368709, ENST00000368707, 
ENST00000518164, ENST00000521291, 
ENST00000396070, ENST00000287038, 
ENST00000523172, 
Fusion gene scores* DoF score8 X 4 X 4=12810 X 7 X 5=350
# samples 1015
** MAII scorelog2(10/128*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/350*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: S100A2 [Title/Abstract] AND RPL30 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL30

GO:0002181

cytoplasmic translation

25957688

TgeneRPL30

GO:0031640

killing of cells of other organism

15019208

TgeneRPL30

GO:0050829

defense response to Gram-negative bacterium

15019208

TgeneRPL30

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BA-A6DL-01AS100A2chr1

153533816

-RPL30chr8

99058697

-
TCGARVHNSCTCGA-CV-7434-01AS100A2chr1

153533816

-RPL30chr8

99058697

-
TCGARVHNSCTCGA-CN-5369-01AS100A2chr1

153533816

-RPL30chr8

99058697

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368708ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368708ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368708ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368708ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368708ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000487430ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000487430ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000487430ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000487430ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000487430ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000497140ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000497140ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000497140ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000497140ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000497140ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368710ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368710ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368710ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368710ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368710ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368709ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368709ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368709ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368709ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
5CDS-intronENST00000368709ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368707ENST00000518164S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368707ENST00000521291S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368707ENST00000396070S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368707ENST00000287038S100A2chr1

153533816

-RPL30chr8

99058697

-
intron-intronENST00000368707ENST00000523172S100A2chr1

153533816

-RPL30chr8

99058697

-

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FusionProtFeatures for S100A2_RPL30


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100A2

P29034

RPL30

P62888

May function as calcium sensor and modulator,contributing to cellular calcium signaling. May function byinteracting with other proteins, such as TPR-containing proteins,and indirectly play a role in many physiological processes. Mayalso play a role in suppressing tumor cell growth.{ECO:0000269|PubMed:1372446, ECO:0000269|PubMed:22399290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for S100A2_RPL30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for S100A2_RPL30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
S100A2S100A2, MDM2, STUB1, ATF2, PPID, FKBP4, S100A1, S100B, HOPX, C17orf105, FOXP2, GMCL1, FAM60ARPL30MAP3K1, NFKB2, POU5F1, MME, NOP56, NEDD4L, VHL, RAD21, ARRB2, SIRT7, CUL3, CUL4B, CDK2, CUL1, COPS5, CAND1, APP, RPS11, RPL4, RPL6, RPS13, RPL8, RPL10A, RPL12, RPL15, RPL18A, RPL19, RPL37A, RPL5, RPL7A, RPL7, RPS14, RPS15A, RPS24, RPS2, RPS5, RPS8, RPSA, RPL11, RPL18, RPS6, RPL31, RPS4X, RPS7, RPS9, RPS23, RPL23, RPL23A, RPL27, RPS3, RPL22, RPL36, RPL21, RPL13, RPL14, RPL10, RPS3A, RPLP0, RPL27A, RPS16, RPL35, RPS26, RPL38, EEF1A1, RPS29, RPS21, RPL37, NHP2L1, NOP58, HNRNPM, HNRNPU, RPLP0P6, NIFK, RPL10L, NOP2, BOP1, KAT5, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CASP2, OAS1, MAP2K7, RPL13A, G0S2, FAM120B, ZFAND2A, USP14, WWOX, ZBTB1, AURKA, CEP250, CEP57, CEP76, TP53, VCP, PHF6, EED, UNK, EEF1A2, POLR1B, POLR3B, RPL24, RPL26, RPL26L1, RPL3, RPL34, RPL3L, RPLP1, RPS10, RPS12, RPS15, RPS19, RPS20, RPS25, RPS27, RPL9, RPLP2, RPS18, LOC101929876, FOSL2, C10orf12, LDHD, SKI, MCM2, RC3H1, HIST1H1C, HIST1H1T, RRP8, KIAA0020, RBM34, RBM28, NSA2, REXO4, ZC3HAV1, ZNF184, PPAN-P2RY11, WHSC1, PAK1IP1, FTSJ3, BRIX1, ZNF512, ZNF70, DDX24, ZNF354A, GTPBP4, CCDC137, DDX31, DDX27, GNL2, ZC3H10, ZFP62, PRDM15, EBNA1BP2, RPL32, GLYR1, ZNF22, DKC1, STAU1, NSUN4, RPF1, NIP7, RPF2, MAK16, IMP4, ZNF189, NMNAT1, CNBP, CENPN, DHX30, HP1BP3, TTF1, MYBBP1A, FCF1, RPL28, NLE1, ZNF771, ZNF668, ZSCAN25, ZNF574, TAF1A, LLPH, DDX10, PRKRA, ZNF142, DDX21, GZF1, LYAR, RPL7L1, PAPD5, SURF6, GPATCH4, RSL24D1, SMARCA5, DDX56, PTPN6, CYLD, INO80B, COX15, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, SOD1, VDAC1, FOXA1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for S100A2_RPL30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100A2P29034DB00768OlopatadineProtein S100-A2small moleculeapproved
HgeneS100A2P29034DB01593ZincProtein S100-A2small moleculeapproved|investigational
HgeneS100A2P29034DB01373CalciumProtein S100-A2small moleculeapproved|nutraceutical

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RelatedDiseases for S100A2_RPL30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource