FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32476

FusionGeneSummary for S100A16_HTATSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: S100A16_HTATSF1
Fusion gene ID: 32476
HgeneTgene
Gene symbol

S100A16

HTATSF1

Gene ID

140576

27336

Gene nameS100 calcium binding protein A16HIV-1 Tat specific factor 1
SynonymsAAG13|DT1P1A7|S100FTAT-SF1|TATSF1|dJ196E23.2
Cytomap

1q21.3

Xq26.3

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-A16aging-associated gene 13 proteinaging-associated protein 13protein S100-FHIV Tat-specific factor 1HIV TAT specific factor 1cofactor required for Tat activation of HIV-1 transcription
Modification date2018051920180523
UniProtAcc

Q96FQ6

O43719

Ensembl transtripts involved in fusion geneENST00000368704, ENST00000368706, 
ENST00000368703, ENST00000368705, 
ENST00000474991, 
ENST00000535601, 
ENST00000218364, 
Fusion gene scores* DoF score3 X 4 X 1=123 X 3 X 2=18
# samples 43
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: S100A16 [Title/Abstract] AND HTATSF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI343506S100A16chr1

153579487

+HTATSF1chrX

135594016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368704ENST00000535601S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368704ENST00000218364S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368706ENST00000535601S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368706ENST00000218364S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368703ENST00000535601S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368703ENST00000218364S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368705ENST00000535601S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000368705ENST00000218364S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000474991ENST00000535601S100A16chr1

153579487

+HTATSF1chrX

135594016

-
intron-3CDSENST00000474991ENST00000218364S100A16chr1

153579487

+HTATSF1chrX

135594016

-

Top

FusionProtFeatures for S100A16_HTATSF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100A16

Q96FQ6

HTATSF1

O43719

Calcium-binding protein. Binds one calcium ion permonomer (PubMed:17030513). Can promote differentiation ofadipocytes (in vitro) (By similarity). Overexpression inpreadipocytes increases their proliferation, enhances adipogenesisand reduces insulin-stimulated glucose uptake (By similarity).{ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. Functions as a general transcription factor playing arole in the process of transcriptional elongation. May mediate thereciprocal stimulatory effect of splicing on transcriptionalelongation. In case of infection by HIV-1, it is up-regulated bythe HIV-1 proteins NEF and gp120, acts as a cofactor required forthe Tat-enhanced transcription of the virus.{ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543,ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046,ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670,ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for S100A16_HTATSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for S100A16_HTATSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for S100A16_HTATSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100A16Q96FQ6DB11093Calcium CitrateProtein S100-A16small moleculeapproved
HgeneS100A16Q96FQ6DB11348Calcium PhosphateProtein S100-A16small moleculeapproved

Top

RelatedDiseases for S100A16_HTATSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource