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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32470

FusionGeneSummary for S100A13_AEBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: S100A13_AEBP2
Fusion gene ID: 32470
HgeneTgene
Gene symbol

S100A13

AEBP2

Gene ID

6284

121536

Gene nameS100 calcium binding protein A13AE binding protein 2
Synonyms--
Cytomap

1q21.3

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-A13zinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2
Modification date2018052220180519
UniProtAcc

Q99584

Q6ZN18

Ensembl transtripts involved in fusion geneENST00000339556, ENST00000392622, 
ENST00000392623, ENST00000440685, 
ENST00000368699, ENST00000491177, 
ENST00000541908, ENST00000398864, 
ENST00000266508, ENST00000360995, 
Fusion gene scores* DoF score5 X 5 X 2=508 X 7 X 5=280
# samples 58
** MAII scorelog2(5/50*10)=0log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: S100A13 [Title/Abstract] AND AEBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneS100A13

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

15033494

HgeneS100A13

GO:0050703

interleukin-1 alpha secretion

12746488


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA414442S100A13chr1

153604251

+AEBP2chr12

19592963

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000339556ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000339556ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000339556ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000339556ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392622ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392622ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392622ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392622ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392623ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392623ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392623ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000392623ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000440685ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000440685ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000440685ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000440685ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000368699ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000368699ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000368699ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000368699ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000491177ENST00000541908S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000491177ENST00000398864S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000491177ENST00000266508S100A13chr1

153604251

+AEBP2chr12

19592963

+
intron-intronENST00000491177ENST00000360995S100A13chr1

153604251

+AEBP2chr12

19592963

+

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FusionProtFeatures for S100A13_AEBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100A13

Q99584

AEBP2

Q6ZN18

Plays a role in the export of proteins that lack asignal peptide and are secreted by an alternative pathway. Bindstwo calcium ions per subunit. Binds one copper ion. Binding of onecopper ion does not interfere with calcium binding. Required forthe copper-dependent stress-induced export of IL1A and FGF1. Thecalcium-free protein binds to lipid vesicles containingphosphatidylserine, but not to vesicles containingphosphatidylcholine (By similarity). {ECO:0000250,ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}. DNA-binding transcriptional repressor. May interact withand stimulate the activity of the PRC2 complex, which methylates'Lys-9' and 'Lys-27' residues of histone H3.{ECO:0000269|PubMed:15225548}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for S100A13_AEBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for S100A13_AEBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for S100A13_AEBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100A13Q99584DB00768OlopatadineProtein S100-A13small moleculeapproved
HgeneS100A13Q99584DB01164Calcium ChlorideProtein S100-A13small moleculeapproved
HgeneS100A13Q99584DB11093Calcium CitrateProtein S100-A13small moleculeapproved
HgeneS100A13Q99584DB11348Calcium PhosphateProtein S100-A13small moleculeapproved
HgeneS100A13Q99584DB01025AmlexanoxProtein S100-A13small moleculeapproved|investigational
HgeneS100A13Q99584DB01373CalciumProtein S100-A13small moleculeapproved|nutraceutical

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RelatedDiseases for S100A13_AEBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource