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Fusion gene ID: 32453 |
FusionGeneSummary for RYK_RABL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RYK_RABL3 | Fusion gene ID: 32453 | Hgene | Tgene | Gene symbol | RYK | RABL3 | Gene ID | 6259 | 285282 |
| Gene name | receptor-like tyrosine kinase | RAB, member of RAS oncogene family like 3 | |
| Synonyms | D3S3195|JTK5|JTK5A|RYK1 | - | |
| Cytomap | 3q22.2 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase RYKJTK5A protein tyrosine kinasehydroxyaryl-protein kinase | rab-like protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P34925 | Q5HYI8 | |
| Ensembl transtripts involved in fusion gene | ENST00000296084, ENST00000427044, ENST00000484106, | ENST00000273375, ENST00000491398, ENST00000483733, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RYK [Title/Abstract] AND RABL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RYK | GO:0006468 | protein phosphorylation | 10454588 |
| Hgene | RYK | GO:0043410 | positive regulation of MAPK cascade | 10454588 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0DL-01A | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| TCGA | LD | BRCA | TCGA-BH-A0DL-01A | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296084 | ENST00000273375 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000296084 | ENST00000491398 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000296084 | ENST00000483733 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| In-frame | ENST00000427044 | ENST00000273375 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000427044 | ENST00000491398 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000427044 | ENST00000483733 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| intron-3CDS | ENST00000484106 | ENST00000273375 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| intron-5UTR | ENST00000484106 | ENST00000491398 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| intron-5UTR | ENST00000484106 | ENST00000483733 | RYK | chr3 | 133921574 | - | RABL3 | chr3 | 120417420 | - |
| Frame-shift | ENST00000296084 | ENST00000273375 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000296084 | ENST00000491398 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000296084 | ENST00000483733 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| Frame-shift | ENST00000427044 | ENST00000273375 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000427044 | ENST00000491398 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| 5CDS-5UTR | ENST00000427044 | ENST00000483733 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| intron-3CDS | ENST00000484106 | ENST00000273375 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| intron-5UTR | ENST00000484106 | ENST00000491398 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
| intron-5UTR | ENST00000484106 | ENST00000483733 | RYK | chr3 | 133913926 | - | RABL3 | chr3 | 120417420 | - |
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FusionProtFeatures for RYK_RABL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RYK | RABL3 |
| May be a coreceptor along with FZD8 of Wnt proteins,such as WNT1, WNT3, WNT3A and WNT5A. Involved in neurondifferentiation, axon guidance, corpus callosum establishment andneurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allowsthe C-terminal intracellular product to translocate from thecytoplasm to the nucleus where it plays a crucial role in neuronaldevelopment. {ECO:0000269|PubMed:15454084}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 24_53 | 260 | 609 | Compositional bias | Pro-rich |
| Hgene | RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 66_194 | 260 | 609 | Domain | WIF |
| Hgene | RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 26_227 | 260 | 609 | Topological domain | Extracellular |
| Hgene | RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 228_248 | 260 | 609 | Transmembrane | Helical |
| Tgene | >RABL3 | chr3:133921574 | chr3:120417420 | ENST00000273375 | - | 3 | 8 | 147_150 | 127 | 237 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 330_603 | 260 | 609 | Domain | Protein kinase |
| Hgene | >RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 336_344 | 260 | 609 | Nucleotide binding | ATP |
| Hgene | >RYK | chr3:133921574 | chr3:120417420 | ENST00000296084 | - | 7 | 16 | 249_607 | 260 | 609 | Topological domain | Cytoplasmic |
| Tgene | RABL3 | chr3:133921574 | chr3:120417420 | ENST00000273375 | - | 3 | 8 | 13_20 | 127 | 237 | Nucleotide binding | GTP |
| Tgene | RABL3 | chr3:133921574 | chr3:120417420 | ENST00000273375 | - | 3 | 8 | 66_70 | 127 | 237 | Nucleotide binding | GTP |
| Tgene | RABL3 | chr3:133921574 | chr3:120417420 | ENST00000273375 | - | 3 | 8 | 1_236 | 127 | 237 | Region | Note=Small GTPase-like |
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FusionGeneSequence for RYK_RABL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RYK_ENST00000296084_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_370aa AWAARLGRPGRSCLPGARGRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLIS HYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKN FTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFAD NQIPLLVIGTKLDQIHETKRHEVLTRTAFLAEDFNPEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPGFPDRKRFGA >In-frame_RYK_ENST00000427044_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_180aa MCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFADNQIPLLVIGT KLDQIHETKRHEVLTRTAFLAEDFNPEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPGFPDRKRFGAGTLKSLHYDX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RYK_ENST00000296084_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_1110nt GCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTG CTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCGCCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCC AGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGT CACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAG CTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTG TTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAAT TTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGA ACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTC GTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGAT AACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATGAAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTG GCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCACGGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGT AGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTAATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCA >In-frame_RYK_ENST00000427044_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_540nt ATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCA ACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTT CATAGTATGAAAAGGATTGAACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGATAACCAAATACCACTGTTGGTAATAGGGACT AAACTGGACCAGATTCATGAAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTGGCTGAGGATTTCAATCCAGAAGAAATTAAT TTGGACTGCACAAATCCACGGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGTAGGTTTTTTGATAAGGTCATAGAGAAGAGA TACTTTTTAAGAGAAGGTAATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCAGGAACATTAAAGAGCCTTCATTATGACTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RYK_ENST00000296084_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_4252nt GCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTG CTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCGCCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCC AGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGT CACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAG CTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTG TTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAAT TTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGA ACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTC GTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGAT AACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATGAAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTG GCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCACGGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGT AGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTAATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCA GGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGAAGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGC TGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAATGCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGA AGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTTACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTG TAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTGTACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTT TTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAGTACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGG GAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTGTCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCC ACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCTCTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGG ACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAACAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGA AAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAGGTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTG CACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTTAAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCA GAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAGTAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGA ACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGTGTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTT TTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCCTGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACA CTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTCCTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATA CAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACTTTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAA TCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCTTTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAA AGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCTTTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAA AGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGTTGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTAC CCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATAAATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAA AAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAAATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACT TTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGGCCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAAT TAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCA GTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGACTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATA TAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCTGGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCA GCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTTAATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCA TAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAAAAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACT ATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATATTTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTA TAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGGGAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTT CCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATATCTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTT TTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGTGAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTC TGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGGCTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACAT AACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGGTTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGG CCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCATTCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAA GAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACCATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCAT AAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTCATTTCTGAAGATTCCTGTCATGTAAAACTTACAGTAAATAA >In-frame_RYK_ENST00000427044_chr3_133921574_-_RABL3_ENST00000273375_chr3_120417420_-_4293nt CGGACGATGCAGCGAGGAGGCGGCGGCGGCGGCGGCCATGCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCC CGCGGCTGAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTGCTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCG CCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTC TTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGTCACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCC TGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAGCTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCA ACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTGTTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGA TACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAATTTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTG AAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGT TTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTG AACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGATAACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATG AAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTGGCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCAC GGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGTAGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTA ATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCAGGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGA AGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGCTGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAAT GCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGAAGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTT ACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTGTAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTG TACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTTTTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAG TACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGGGAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTG TCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCCACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCT CTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGGACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAA CAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGAAAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAG GTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTGCACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTT AAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCAGAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAG TAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGAACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGT GTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTTTTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCC TGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACACTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTC CTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATACAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACT TTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAATCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCT TTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAAAGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCT TTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAAAGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGT TGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTACCCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATA AATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAAAAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAA ATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACTTTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGG CCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCT GAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGA CTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATATAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCT GGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCAGCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTT AATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCATAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAA AAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACTATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATAT TTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTATAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGG GAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTTCCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATAT CTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTTTTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGT GAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTCTGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGG CTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACATAACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGG TTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGGCCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCAT TCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAAGAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACC ATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCATAAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTC |
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FusionGenePPI for RYK_RABL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RYK | EPHB2, EPHB3, CDC37, UBC, MIB1, PRKDC, GPR125, DSG2, CELSR2, DSC3, PTK7, CD276, NCR3LG1, CELSR1, FREM2, TP53, CNNM3, VIM, MAPK1, PCNA, NCKAP1, AGK, AIFM1, CNNM2, GPR124, FAT4, CDHR1, WASF2, CTNNA1, DCHS1, NOMO3, NPEPPS, PCDH9, ABI1, APLP2, MAPK3, CYFIP1, ITM2B, PTPRS, ITM2C, NRP2, PTPRF, TMED10, DYNC1H1, PCDH7, PCDH20, TFRC, PCDHGA11, PARP1, TMEM59, VPS26A, WASF1, WASF3, CDK1, DSC2, NPM1, TRAP1, CDH2, VPS35, CTNNB1, NUP93, EPHA4, RHOT2, ST13, CELSR3, FAT3, OSGEP, TIMM50, ELAVL1, CFTR, SHMT2, MOV10, NXF1, CEACAM21, MICA, SLC39A5, TNFSF8, PVR, RAET1E, MILR1, SIGLECL1, CDH5, PPP3CA, PPM1B, PTPRR | RABL3 | APP, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, PKN2, MAPK8, ATP6AP2, FGFR1OP, ATL3, GOLT1B, TMEM63B, YIPF5, PTAR1, SIRT5, RELL1, RHOA, RAP1GDS1, GPR89A, STOM |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RYK_RABL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RYK_RABL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RYK | C0008925 | Cleft Palate | 1 | CTD_human |
| Hgene | RYK | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | RYK | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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