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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32423

FusionGeneSummary for RUSC2_GH2

check button Fusion gene summary
Fusion gene informationFusion gene name: RUSC2_GH2
Fusion gene ID: 32423
HgeneTgene
Gene symbol

RUSC2

GH2

Gene ID

9853

2689

Gene nameRUN and SH3 domain containing 2growth hormone 2
SynonymsIporin|MRT61GH-V|GHB2|GHL|GHV|hGH-V
Cytomap

9p13.3

17q23.3

Type of geneprotein-codingprotein-coding
DescriptioniporinRUN and SH3 domain-containing protein 2interacting protein of Rab1growth hormone variantgrowth hormone B2placenta-specific growth hormoneplacental-specific growth hormone
Modification date2018051920180523
UniProtAcc

Q8N2Y8

P01242

Ensembl transtripts involved in fusion geneENST00000455600, ENST00000468041, 
ENST00000456543, ENST00000449787, 
ENST00000423893, ENST00000332800, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: RUSC2 [Title/Abstract] AND GH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC020828RUSC2chr9

35508705

+GH2chr17

61957624

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000455600ENST00000456543RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000455600ENST00000449787RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000455600ENST00000423893RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000455600ENST00000332800RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3CDSENST00000468041ENST00000456543RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000468041ENST00000449787RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000468041ENST00000423893RUSC2chr9

35508705

+GH2chr17

61957624

-
intron-3UTRENST00000468041ENST00000332800RUSC2chr9

35508705

+GH2chr17

61957624

-

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FusionProtFeatures for RUSC2_GH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUSC2

Q8N2Y8

GH2

P01242

Plays an important role in growth control. Its majorrole in stimulating body growth is to stimulate the liver andother tissues to secrete IGF-1. It stimulates both thedifferentiation and proliferation of myoblasts. It also stimulatesamino acid uptake and protein synthesis in muscle and othertissues.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUSC2_GH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RUSC2_GH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUSC2_GH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RUSC2_GH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGH2C0175693Russell-Silver syndrome1CTD_human