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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32401

FusionGeneSummary for RUNX1_MECOM

check button Fusion gene summary
Fusion gene informationFusion gene name: RUNX1_MECOM
Fusion gene ID: 32401
HgeneTgene
Gene symbol

RUNX1

MECOM

Gene ID

861

2122

Gene namerunt related transcription factor 1MDS1 and EVI1 complex locus
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2
Cytomap

21q22.12

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2MDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1onc
Modification date2018052720180522
UniProtAcc

Q01196

Q03112

Ensembl transtripts involved in fusion geneENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
ENST00000264674, ENST00000392736, 
ENST00000464456, ENST00000472280, 
ENST00000494292, ENST00000468789, 
ENST00000460814, ENST00000433243, 
ENST00000485957, 
Fusion gene scores* DoF score23 X 25 X 7=40258 X 7 X 6=336
# samples 5310
** MAII scorelog2(53/4025*10)=-2.92492451843878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUNX1 [Title/Abstract] AND MECOM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977

TgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

TgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

TgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLAMLTCGA-AB-2915-03ARUNX1chr21

36206707

-MECOMchr3

169099312

-
ChiTaRS3.1L21756RUNX1chr21

36206707

-MECOMchr3

169201751

-
ChiTaRS3.1S69002RUNX1chr21

36231771

-MECOMchr3

169099312

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344691ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-5UTRENST00000344691ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-5UTRENST00000325074ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-5UTRENST00000437180ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-5UTRENST00000300305ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000399240ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-5UTRENST00000399240ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000486278ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-5UTRENST00000486278ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
intron-5UTRENST00000494829ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-5UTRENST00000358356ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000325074ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000437180ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000300305ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000399240ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000486278ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
intron-intronENST00000494829ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000264674RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000392736RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000464456RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000472280RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000494292RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000468789RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000460814RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000433243RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000358356ENST00000485957RUNX1chr21

36206707

-MECOMchr3

169201751

-
5CDS-intronENST00000344691ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000344691ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000344691ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000325074ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000325074ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000437180ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000437180ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000300305ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000300305ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000399240ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000399240ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000486278ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000486278ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-intronENST00000494829ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
intron-5UTRENST00000494829ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000264674RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000392736RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000464456RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000472280RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000494292RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000468789RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000460814RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-intronENST00000358356ENST00000433243RUNX1chr21

36231771

-MECOMchr3

169099312

-
5CDS-5UTRENST00000358356ENST00000485957RUNX1chr21

36231771

-MECOMchr3

169099312

-

Top

FusionProtFeatures for RUNX1_MECOM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1

Q01196

MECOM

Q03112


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUNX1_MECOM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RUNX1_MECOM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2MECOMHDAC1, CTBP1, HDAC4, CREBBP, KAT2B, SMAD3, MBD3, SUV39H1, EHMT2, SMAD1, SMAD2, SMAD4, SIRT1, ELAVL1, SOX2, PIAS4, PRMT1, UBE2I, SPDEF, NLRP14, PIK3R3, RABGAP1L, MED23, HIC1, FOXJ2, ERMAP, L3MBTL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RUNX1_MECOM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RUNX1_MECOM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
HgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
HgeneRUNX1C0017636Glioblastoma1CTD_human
HgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
HgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
HgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneMECOMC0009375Colonic Neoplasms1CTD_human
TgeneMECOMC0023448Lymphoid leukemia1CTD_human
TgeneMECOMC0023470Myeloid Leukemia1CTD_human
TgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
TgeneMECOMC0919267ovarian neoplasm1CTD_human
TgeneMECOMC1458155Mammary Neoplasms1CTD_human
TgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 21UNIPROT