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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3240

FusionGeneSummary for ATN1_LRRC23

check button Fusion gene summary
Fusion gene informationFusion gene name: ATN1_LRRC23
Fusion gene ID: 3240
HgeneTgene
Gene symbol

ATN1

LRRC23

Gene ID

1822

10233

Gene nameatrophin 1leucine rich repeat containing 23
SynonymsB37|D12S755E|DRPLA|HRS|NODLRPB7
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionatrophin-1dentatorubral-pallidoluysian atrophy proteinleucine-rich repeat-containing protein 23leucine-rich protein B7
Modification date2018052320180523
UniProtAcc

P54259

Q53EV4

Ensembl transtripts involved in fusion geneENST00000356654, ENST00000396684, 
ENST00000433346, ENST00000449039, 
ENST00000007969, ENST00000323702, 
ENST00000443597, ENST00000436789, 
ENST00000429740, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 4 X 6=168
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATN1 [Title/Abstract] AND LRRC23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATN1

GO:0000122

negative regulation of transcription by RNA polymerase II

10973986

HgeneATN1

GO:0051402

neuron apoptotic process

10085113


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0B9-01AATN1chr12

7037547

+LRRC23chr12

7014749

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000356654ENST00000433346ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-3UTRENST00000356654ENST00000449039ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-5UTRENST00000356654ENST00000007969ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-5UTRENST00000356654ENST00000323702ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-5UTRENST00000356654ENST00000443597ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-5UTRENST00000356654ENST00000436789ATN1chr12

7037547

+LRRC23chr12

7014749

+
intron-intronENST00000356654ENST00000429740ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-5UTRENST00000396684ENST00000433346ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-3UTRENST00000396684ENST00000449039ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-5UTRENST00000396684ENST00000007969ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-5UTRENST00000396684ENST00000323702ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-5UTRENST00000396684ENST00000443597ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-5UTRENST00000396684ENST00000436789ATN1chr12

7037547

+LRRC23chr12

7014749

+
5UTR-intronENST00000396684ENST00000429740ATN1chr12

7037547

+LRRC23chr12

7014749

+

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FusionProtFeatures for ATN1_LRRC23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATN1

P54259

LRRC23

Q53EV4

Transcriptional corepressor. Recruits NR2E1 to represstranscription. Promotes vascular smooth cell (VSMC) migration andorientation (By similarity). Corepressor of MTG8 transcriptionalrepression. Has some intrinsic repression activity which isindependent of the number of poly-Gln (polyQ) repeats.{ECO:0000250, ECO:0000269|PubMed:10085113,ECO:0000269|PubMed:10973986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATN1_LRRC23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATN1_LRRC23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATN1KAT7, TLE1, VIM, RERE, BAIAP2, CTNND2, DVL1, LYST, MAGI2, ITCH, WWP2, WWP1, MAGI1, GIGYF2, NR2E1, RUNX1T1, TERF1, TERF2, RNF115, EWSR1, GCC1, KRTAP4-12, LENG8, MDFI, CRACR2A, NCK2, RHOXF2, PLSCR1, PSME3, RBPMS, TRIP6, WDR5, RBFOX1, AGRN, ATN1, BAG6, CACNB1, CBFA2T2, CENPJ, CHRD, CRIP2, DVL2, EFEMP1, EFEMP2, MEGF6, MEGF8, FBLN1, GAPDH, GRN, HSPG2, JAG2, SSPO, LTBP1, LTBP4, MBP, MEGF11, NELL1, NELL2, GIGYF1, PFKL, RCHY1, SLIT1, STXBP4, SYVN1, TEP1, ZMYND8, RBM10, ALG13, FBLN5, LRP2, PCSK5, PSMA3, AES, ARF3, PRRC2A, NOC2L, DMPK, ECM1, FBLN2, MAP7D1, PRRC2B, ZSWIM8, KRT31, KAT6A, KAT6B, RBFOX2, RNF31, SIAH1, SIAH2, SPAG5, RAD54L2, USP54, HINFP, WWOX, AUTS2, TRIM25LRRC23AK9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATN1_LRRC23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATN1_LRRC23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource