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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32399

FusionGeneSummary for RUNX1_GRM7

check button Fusion gene summary
Fusion gene informationFusion gene name: RUNX1_GRM7
Fusion gene ID: 32399
HgeneTgene
Gene symbol

RUNX1

GRM7

Gene ID

861

2917

Gene namerunt related transcription factor 1glutamate metabotropic receptor 7
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaGLUR7|GPRC1G|MGLU7|MGLUR7|PPP1R87
Cytomap

21q22.12

3p26.1

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2metabotropic glutamate receptor 7glutamate receptor, metabotropic 7protein phosphatase 1, regulatory subunit 87
Modification date2018052720180523
UniProtAcc

Q01196

Q14831

Ensembl transtripts involved in fusion geneENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
ENST00000357716, ENST00000486284, 
ENST00000389336, ENST00000402647, 
ENST00000403881, ENST00000458641, 
Fusion gene scores* DoF score23 X 25 X 7=40259 X 7 X 7=441
# samples 539
** MAII scorelog2(53/4025*10)=-2.92492451843878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUNX1 [Title/Abstract] AND GRM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977

TgeneGRM7

GO:0007196

adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway

9473604

TgeneGRM7

GO:0007268

chemical synaptic transmission

9473604


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY509915RUNX1chr21

36206777

+GRM7chr3

7723965

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000344691ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000344691ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000344691ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000344691ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000344691ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000344691ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000325074ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000437180ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000300305ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000399240ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000486278ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000494829ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000357716RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000486284RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000389336RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000402647RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000403881RUNX1chr21

36206777

+GRM7chr3

7723965

+
intron-intronENST00000358356ENST00000458641RUNX1chr21

36206777

+GRM7chr3

7723965

+

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FusionProtFeatures for RUNX1_GRM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1

Q01196

GRM7

Q14831

G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors, such as adenylate cyclase.Signaling inhibits adenylate cyclase activity.{ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUNX1_GRM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RUNX1_GRM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUNX1_GRM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM7Q14831DB00142Glutamic AcidMetabotropic glutamate receptor 7small moleculeapproved|nutraceutical

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RelatedDiseases for RUNX1_GRM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
HgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
HgeneRUNX1C0017636Glioblastoma1CTD_human
HgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
HgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
HgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneGRM7C0011570Mental Depression5PSYGENET
TgeneGRM7C0011581Depressive disorder5PSYGENET
TgeneGRM7C0041696Unipolar Depression5PSYGENET
TgeneGRM7C1269683Major Depressive Disorder5PSYGENET
TgeneGRM7C0036341Schizophrenia4PSYGENET
TgeneGRM7C0005586Bipolar Disorder3PSYGENET
TgeneGRM7C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM7C0236969Substance-Related Disorders1CTD_human
TgeneGRM7C1263846Attention deficit hyperactivity disorder1CTD_human