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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32387

FusionGeneSummary for RUNX1T1_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: RUNX1T1_RUNX1
Fusion gene ID: 32387
HgeneTgene
Gene symbol

RUNX1T1

RUNX1

Gene ID

862

861

Gene nameRUNX1 translocation partner 1runt related transcription factor 1
SynonymsAML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

8q21.3

21q22.12

Type of geneprotein-codingprotein-coding
Descriptionprotein CBFA2T1acute myelogenous leukemia 1 translocation 1, cyclin-D relatedcore-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-relatedeight twenty one proteinmyeloid translocation gene on 8q22runt related transcription frunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018052320180527
UniProtAcc

Q06455

Q01196

Ensembl transtripts involved in fusion geneENST00000523629, ENST00000396218, 
ENST00000265814, ENST00000360348, 
ENST00000436581, ENST00000520724, 
ENST00000518844, ENST00000522163, 
ENST00000422361, ENST00000521553, 
ENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
Fusion gene scores* DoF score10 X 12 X 5=60017 X 29 X 7=3451
# samples 1233
** MAII scorelog2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUNX1T1 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1T1

GO:0045892

negative regulation of transcription, DNA-templated

23251453

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLAMLTCGA-AB-2875-03ARUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
ChiTaRS3.1DQ202694RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
ChiTaRS3.1DQ202692RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000523629ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000523629ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000523629ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000523629ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000523629ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000523629ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000523629ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000523629ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000396218ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5CDS-intronENST00000396218ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5CDS-intronENST00000396218ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000265814ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000265814ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000265814ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000360348ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000360348ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000360348ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000436581ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000436581ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000436581ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000520724ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000520724ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000520724ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
Frame-shitENST00000518844ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5CDS-intronENST00000518844ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5CDS-intronENST00000518844ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-3CDSENST00000522163ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-intronENST00000522163ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
5UTR-intronENST00000522163ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000422361ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000422361ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000422361ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000344691RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000325074RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000437180RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000300305RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000399240RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-3CDSENST00000521553ENST00000486278RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000521553ENST00000494829RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000521553ENST00000358356RUNX1T1chr8

93074774

-RUNX1chr21

36231875

-
intron-intronENST00000523629ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000396218ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000265814ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000360348ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000436581ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000520724ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000518844ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000522163ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000422361ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000344691RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000325074RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000437180RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000300305RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000399240RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000486278RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000494829RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000521553ENST00000358356RUNX1T1chr8

93082546

-RUNX1chr21

36219456

-
intron-intronENST00000523629ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000523629ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000396218ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000265814ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000360348ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000436581ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000520724ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000518844ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000522163ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000422361ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000344691RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000325074RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000437180RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000300305RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000399240RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000486278RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000494829RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-
intron-intronENST00000521553ENST00000358356RUNX1T1chr8

93086896

-RUNX1chr21

36211486

-

Top

FusionProtFeatures for RUNX1T1_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1T1

Q06455

RUNX1

Q01196


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUNX1T1_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RUNX1T1_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RUNX1T1ABI3, C19orf57, NECAB2, WBP11, TAF9B, CBFA2T2, CEP170P1, OTUD4, THRAP3, NCOR2, CBFA2T3, NCOR1, HDAC1, HDAC2, HDAC3, HDAC8, PRKAR2A, RUNX1T1, KPNB1, KPNA1, VDR, SIN3A, ZBTB16, GFI1, NEUROG1, TAL2, PRDM14, PCBD2, TCF12, TCF3, ATN1, RUNX1, TRIM33, UBE2E2, SPEN, RBPJ, DNMT1, ETS1, BCL6, UBQLN4, EPS8, MEOX2, STX11, ZMYM4, LPXN, HOMER3, SPRY2, MID2, GSE1, CPSF7, EFHC2, LZTS2, CREB3L1, SPERT, TRIM42, CCDC36, BRCA1, TCF4, SYCE3, PSMC5, BSPRYRUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUNX1T1_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RUNX1T1_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1T1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneRUNX1T1C0149925Small cell carcinoma of lung1CTD_human
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human