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Fusion gene ID: 32367

FusionGeneSummary for RTN4_ENTPD1

Fusion gene summary

Fusion gene information	Fusion gene name: RTN4_ENTPD1
	Fusion gene ID: 32367
		Hgene	Tgene
	Gene symbol	RTN4	ENTPD1
	Gene ID	57142	953
	Gene name	reticulon 4	ectonucleoside triphosphate diphosphohydrolase 1
	Synonyms	ASY\|NI220/250\|NOGO\|NSP\|NSP-CL\|Nbla00271\|Nbla10545\|RTN-X\|RTN4-A\|RTN4-B1\|RTN4-B2\|RTN4-C	ATPDase\|CD39\|NTPDase-1\|SPG64
	Cytomap	2p16.1	10q24.1
	Type of gene	protein-coding	protein-coding
	Description	reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5	ectonucleoside triphosphate diphosphohydrolase 1CD39 antigenecto-ATP diphosphohydrolase 1ecto-ATPDase 1ecto-ATPase 1ecto-apyraselymphoid cell activation antigen
	Modification date	20180523	20180519
	UniProtAcc	Q9NQC3	P49961
	Ensembl transtripts involved in fusion gene	ENST00000394609, ENST00000405240, ENST00000357376, ENST00000317610, ENST00000357732, ENST00000337526, ENST00000394611, ENST00000404909, ENST00000486085, ENST00000354474, ENST00000402434,	ENST00000453258, ENST00000543964, ENST00000371207, ENST00000371203, ENST00000539125, ENST00000371205, ENST00000490659,
Fusion gene scores	* DoF score	8 X 15 X 4=480	4 X 5 X 2=40
	# samples	18	5
	** MAII score	log2(18/480*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RTN4 [Title/Abstract] AND ENTPD1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RTN4	GO:0030517	negative regulation of axon extension	10667797
Hgene	RTN4	GO:0071787	endoplasmic reticulum tubular network formation	24262037\|25612671
Hgene	RTN4	GO:1905552	positive regulation of protein localization to endoplasmic reticulum	27353365

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DA313964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000394609	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394609	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394609	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394609	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394609	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394609	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394609	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000405240	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000405240	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000405240	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000405240	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000405240	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000405240	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000405240	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357376	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357376	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357376	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357376	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357376	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357376	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357376	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000317610	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000317610	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000317610	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000317610	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000317610	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000317610	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000317610	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357732	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357732	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357732	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357732	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357732	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000357732	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000357732	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000337526	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000337526	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000337526	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000337526	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000337526	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000337526	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000337526	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394611	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394611	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394611	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394611	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394611	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000394611	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000394611	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000404909	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000404909	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000404909	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000404909	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000404909	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000404909	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000404909	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000486085	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000486085	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000486085	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000486085	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000486085	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000486085	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000486085	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000354474	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000354474	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000354474	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000354474	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000354474	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000354474	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000354474	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000402434	ENST00000453258	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000402434	ENST00000543964	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000402434	ENST00000371207	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000402434	ENST00000371203	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000402434	ENST00000539125	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-5UTR	ENST00000402434	ENST00000371205	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+
intron-intron	ENST00000402434	ENST00000490659	RTN4	chr2	55199667	-	ENTPD1	chr10	97515920	+

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FusionProtFeatures for RTN4_ENTPD1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RTN4 Q9NQC3	ENTPD1 P49961

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for RTN4_ENTPD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RTN4_ENTPD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for RTN4_ENTPD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RTN4_ENTPD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RTN4	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	RTN4	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	RTN4	C0036341	Schizophrenia	1	CTD_human
Tgene	ENTPD1	C3714756	Intellectual Disability	1	CTD_human;HPO
Tgene	ENTPD1	C3810289	SPASTIC PARAPLEGIA 64, AUTOSOMAL RECESSIVE	1	ORPHANET;UNIPROT

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Fusion gene ID: 32367

FusionGeneSummary for RTN4_ENTPD1

FusionProtFeatures for RTN4_ENTPD1

FusionGeneSequence for RTN4_ENTPD1

FusionGenePPI for RTN4_ENTPD1

RelatedDrugs for RTN4_ENTPD1

RelatedDiseases for RTN4_ENTPD1