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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32349

FusionGeneSummary for RTN1_DPYSL2

check button Fusion gene summary
Fusion gene informationFusion gene name: RTN1_DPYSL2
Fusion gene ID: 32349
HgeneTgene
Gene symbol

RTN1

DPYSL2

Gene ID

6252

1808

Gene namereticulon 1dihydropyrimidinase like 2
SynonymsNSPCRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2
Cytomap

14q23.1

8p21.2

Type of geneprotein-codingprotein-coding
Descriptionreticulon-1neuroendocrine-specific proteindihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2
Modification date2018052220180519
UniProtAcc

Q16799

Q16555

Ensembl transtripts involved in fusion geneENST00000267484, ENST00000395090, 
ENST00000342503, ENST00000557422, 
ENST00000521913, ENST00000311151, 
ENST00000523027, ENST00000521983, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 4=36
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RTN1 [Title/Abstract] AND DPYSL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK054747RTN1chr14

60067154

-DPYSL2chr8

26514351

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000267484ENST00000521913RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000267484ENST00000311151RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000267484ENST00000523027RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000267484ENST00000521983RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000395090ENST00000521913RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000395090ENST00000311151RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000395090ENST00000523027RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000395090ENST00000521983RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000342503ENST00000521913RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000342503ENST00000311151RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000342503ENST00000523027RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000342503ENST00000521983RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000557422ENST00000521913RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-3UTRENST00000557422ENST00000311151RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000557422ENST00000523027RTN1chr14

60067154

-DPYSL2chr8

26514351

+
intron-intronENST00000557422ENST00000521983RTN1chr14

60067154

-DPYSL2chr8

26514351

+

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FusionProtFeatures for RTN1_DPYSL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTN1

Q16799

DPYSL2

Q16555

May be involved in neuroendocrine secretion or inmembrane trafficking in neuroendocrine cells. Plays a role in neuronal development and polarity, aswell as in axon growth and guidance, neuronal growth cone collapseand cell migration. Necessary for signaling by class 3 semaphorinsand subsequent remodeling of the cytoskeleton. May play a role inendocytosis. {ECO:0000269|PubMed:11477421,ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RTN1_DPYSL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RTN1_DPYSL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RTN1_DPYSL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDPYSL2Q16555DB11638ArtenimolDihydropyrimidinase-related protein 2small moleculeapproved|investigational

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RelatedDiseases for RTN1_DPYSL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRTN1C0151744Myocardial Ischemia1CTD_human
TgeneDPYSL2C0005586Bipolar Disorder4PSYGENET
TgeneDPYSL2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneDPYSL2C0002395Alzheimer's Disease1CTD_human
TgeneDPYSL2C0011570Mental Depression1PSYGENET
TgeneDPYSL2C0011581Depressive disorder1PSYGENET
TgeneDPYSL2C0029408Degenerative polyarthritis1CTD_human
TgeneDPYSL2C0033937Psychoses, Drug1PSYGENET
TgeneDPYSL2C0036349Paranoid Schizophrenia1CTD_human