FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32340

FusionGeneSummary for RTKN2_KIAA0100

check button Fusion gene summary
Fusion gene informationFusion gene name: RTKN2_KIAA0100
Fusion gene ID: 32340
HgeneTgene
Gene symbol

RTKN2

KIAA0100

Gene ID

219790

9703

Gene namerhotekin 2KIAA0100
SynonymsPLEKHK1|bA531F24.1BCOX|BCOX1|CT101|FMP27
Cytomap

10q21.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionrhotekin-2PH domain-containing family K member 1pleckstrin homology domain-containing family K member 1protein KIAA0100U937-associated antigenantigen MLAA-22breast cancer overexpressed gene 1breast cancer-overexpressed gene 1 proteincancer/testis antigen 101
Modification date2018052320180519
UniProtAcc

Q8IZC4

Q14667

Ensembl transtripts involved in fusion geneENST00000315289, ENST00000395265, 
ENST00000373789, ENST00000395260, 
ENST00000528896, ENST00000544884, 
ENST00000389003, ENST00000579924, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RTKN2 [Title/Abstract] AND KIAA0100 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF853289RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000315289ENST00000528896RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000315289ENST00000544884RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000315289ENST00000389003RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000315289ENST00000579924RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395265ENST00000528896RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395265ENST00000544884RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395265ENST00000389003RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395265ENST00000579924RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000373789ENST00000528896RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000373789ENST00000544884RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000373789ENST00000389003RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000373789ENST00000579924RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395260ENST00000528896RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395260ENST00000544884RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395260ENST00000389003RTKN2chr10

63986787

+KIAA0100chr17

26966177

+
intron-intronENST00000395260ENST00000579924RTKN2chr10

63986787

+KIAA0100chr17

26966177

+

Top

FusionProtFeatures for RTKN2_KIAA0100


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTKN2

Q8IZC4

KIAA0100

Q14667

May play an important role in lymphopoiesis.{ECO:0000269|PubMed:15504364}. May be involved in membrane trafficking.{ECO:0000250|UniProtKB:K7VLR4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RTKN2_KIAA0100


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RTKN2_KIAA0100


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RTKN2_KIAA0100


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RTKN2_KIAA0100


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRTKN2C0036341Schizophrenia1PSYGENET