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Fusion gene ID: 32323 |
FusionGeneSummary for RTCB_FAM83F |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RTCB_FAM83F | Fusion gene ID: 32323 | Hgene | Tgene | Gene symbol | RTCB | FAM83F | Gene ID | 51493 | 113828 |
| Gene name | RNA 2',3'-cyclic phosphate and 5'-OH ligase | family with sequence similarity 83 member F | |
| Synonyms | C22orf28|DJ149A16.6|FAAP|HSPC117 | - | |
| Cytomap | 22q12.3 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tRNA-splicing ligase RtcB homologankyrin repeat domain 54focal adhesion-associated protein | protein FAM83F | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9Y3I0 | Q8NEG4 | |
| Ensembl transtripts involved in fusion gene | ENST00000216038, ENST00000451746, ENST00000476619, | ENST00000333407, ENST00000488874, ENST00000473717, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 2 X 2 X 2=8 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: RTCB [Title/Abstract] AND FAM83F [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RTCB | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation | 21311021|24870230 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EB-A3Y6-01A | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216038 | ENST00000333407 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5CDS-intron | ENST00000216038 | ENST00000488874 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5CDS-intron | ENST00000216038 | ENST00000473717 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| Frame-shift | ENST00000451746 | ENST00000333407 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5CDS-intron | ENST00000451746 | ENST00000488874 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5CDS-intron | ENST00000451746 | ENST00000473717 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5UTR-3CDS | ENST00000476619 | ENST00000333407 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5UTR-intron | ENST00000476619 | ENST00000488874 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
| 5UTR-intron | ENST00000476619 | ENST00000473717 | RTCB | chr22 | 32802649 | - | FAM83F | chr22 | 40425520 | + |
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FusionProtFeatures for RTCB_FAM83F |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RTCB | FAM83F |
| Catalytic subunit of the tRNA-splicing ligase complexthat acts by directly joining spliced tRNA halves to mature-sizedtRNAs by incorporating the precursor-derived splice junctionphosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substratespecificity, and may function toward other RNAs.{ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RTCB | chr22:32802649 | chr22:40425520 | ENST00000216038 | - | 4 | 12 | 353_354 | 113 | 506 | Nucleotide binding | GMP |
| Hgene | >RTCB | chr22:32802649 | chr22:40425520 | ENST00000216038 | - | 4 | 12 | 400_403 | 113 | 506 | Nucleotide binding | GMP |
| Hgene | >RTCB | chr22:32802649 | chr22:40425520 | ENST00000216038 | - | 4 | 12 | 428_431 | 113 | 506 | Nucleotide binding | GMP |
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FusionGeneSequence for RTCB_FAM83F |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RTCB_ENST00000216038_chr22_32802649_-_FAM83F_ENST00000333407_chr22_40425520_+_130aa MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RTCB_ENST00000216038_chr22_32802649_-_FAM83F_ENST00000333407_chr22_40425520_+_390nt ATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTGCCCAACATG CAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGTGGTGTTGGT GGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGATGTCCATTCA GGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGGTAAAACAAGTCCCAGTTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RTCB_ENST00000216038_chr22_32802649_-_FAM83F_ENST00000333407_chr22_40425520_+_14453nt GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGGTAAAACAAGT CCCAGTTCTGCCAAGCCTAGCAACTGTGTGATTTCCTGAGCTGCGGGATGGTGGTGGGCAGGACGTGTGGATGCCTGCCTGCCCTGCCCT GTGCTGTGGAGAGCGCAGGTCGCACACTGCACCAGTTTGCACATCAGACGCCAACTGGCCTTCTGCCCTGCAGCCTCCGTCCTGGCCTCA GGGACGCTGGATCCCAAATGAGAGGGTCCGAAGCATCTCAGTCACACGCCTCCACCGGACTGTCGGTGGCTGGGCAGGGGTCAGTGCCAC GGCCTCCTTGTTTACATGAAGTGGAAGCTTGACCAGTGTCTGCTCGCCTTTGTGCCCCACCCCCTCCGCTGATTGCCAGATGGGGTGAGG GCCCATTCTTTAAACCTTTATGGGGTGGGGTGTCTGGGGCAGCTGCAGTGGCTTCTCCTTTCCCAGGCTTCCTGGTGCTTCTGGTTCCCC ACGCCACTCCCCACCCAAGAGATTGGTGGAATAAAAGGGAAGAGGGCAGGGCCCTGAGCCTGGGATCCCAAGTTCCAGTCTTTCTCTAGC CTCTGAACTCCAGATGTAAGGTGCAGCTGGAACTGCAGGGGCACTGGCTGCAGTGGCCTTCCTGGCCCCATCCCTGCAGGCTCCTGAACT AGACTTGAATGAGGGTAAGATCCTGCGGCCTCCCGCAGTGGGGGCAGAATTTGACACTGCTTTTCTGAGAGCGCTCGCACTGAGGTCTCT TTTTCCCTGCCCAGTGCCGTCCTGGCAGTCTCGGCATGGGTGGTTGAGACCTCCTTGGCTGCTGCCTGCTGCGGGCCTATGTGGGGGTCC TTACAGGGCCTTTACCTGGGACTGCTCCTTCCCTCAGTCAGTAAACTTTGGTTTACAGCCCAAGGCAGGGAGGGAGCTTGGCTGAGAGGG GATTGGGGGTGTGGGAGGCTGGGCCCTGAGGACAGGAGCATTTGCCTTTTCTCCCTCAACTCTAACGGGGTCCTCGGACCCCTTCACCAA CCAGGGCTTCCAGGTTACACTTTGGCCAGACTGGCCTTTGCCTCCTGCGAGAGTCAGGCCATTTTTAGGAGCCTGTGCCTCGCCAGAGCA GGTCAGCCTAATGGCCATGAGGCTGAGCTGGGAGGCCCAGTAAGCAATTCCATTCTGCCTTCCCCACTTGGGTGACTGGAGAGGGCCGAG GAGAGTTTGTGAATGGACCTGGGAGAAATTGCCAAACTGCAGACTCTGTGAGCCGGCCCTGCCGGCAGGGCGATGGGGGATCCAAGCCCT GTGGAAGAGCCATGCAGCGGACTTTCTTGCCCTCTGACCTCTGAACCAAACTCTCATCCTCTTTCTTTCCTTCTAAAAAACCCTAGGACA CTACCAGCACCTGGGGGAGGGGTACAGATGTCTGCAAGGCAGCTGATGTGAGAGCAAGAAAAGGGGCTGCTCTGGCTGGGCTGTGGGAGC CAGGCATTGCTTCTGAGGAAGCAGGAAGTGGGGACCACATGTGGCGGCCATTGAGGAGATGCAATCTCTCTGGCAGTGGGGAGGGGAAGG GAAAGGAAGGGTGAGCCTGTCCCCAGGGTCTTCTCTGTTAATCCCAAGGCTGGCTTCTAGGGCGTGTGGAGAAGGGACTCTGGCCCACCT CCCTGAGCTTTTATGAAGGTGAAATGCTTCTGGGAAGTGTTTCCTTAGGCACCAAGACCAGGCAGTGTGGCATGAGCTCATTCTGGAGGG GAGGGAAGGGAGAGAGGGGGGAGGTGGGATGTGGGGGTGTTACACCTCAGCTCGAGGCGGACACCTTGAAGGTATGGGACATGAAATGTG TAAACTGCAACGCGGCAAAGAGATCACTCTCTGGTGTGGAGGGTGGGTGTCTCTGGGGATTAGGGAGGCAGCCTGGGGAAGGGACCGGCC TCCAAGCAAGTCAGCCAAGGGCATCTGTGCCTCCCCTGCCAGAAGAGCAGGCCCTGCTTTGTCCCTTTACCTCCTCTAGGCCCAAAGCAC ACCCAGGTCCCTCCCCTGCCCTGACATCTAATCTGGGAGGATCCCTGATTGGAATCTCCAAGTCACCACAGCCTTGAGCCAGGCCTTCCT TTCTGCCTCAGTTTCTCCATGTGCCAAGATGGCGTTTTTCACACTTTCTTAGTAGAAATGATGGGGAGACCATATGTTAGGAAGCAAGTT GGCATAGTGGGAAGAGGGCCAGCCACAAGGCAGGAGTGCCCAGGCAGGGTGCCTCTCCCTGCTGGCCTGTGTCCTCGTCCTTATAGCAGT GTGGACAAGATGGTGTCGGCACCCCCCGCTCCAAAAGGCTTGAGACAGAAACTGTAGTCCGAGATGGCAAGGATTTTGAACTCACAAAAT GCAGCTCTTCATGTTTGCCTGTCTGCCTAGGCACCGGCCCACTCTGTTCTGCCTCTTGGCTTCTCAGCTGTGAGTACGCCTGCCCTCTGT TCCAGCACTTGCACATACTTTGTGAAGCAGTCTCTTACTCATCAAATCTCAAGGGTACATCTGGCCCTCCCAGTTGGATGGCAAGTTCAA GGGTGGATCATGCCCTTGGTCCCTGCACAGCAGCTTCTGCAAGGCTGGTTACATTGGAAGGGCTCTAGGAGGAACAGGATAAGGCAGCAC TCTCGGGGCTGGGGTCTGGCTTCACTGCACCCCCCTCCCACCCCACACCACCACCAAGCTGCTGTCTTTCTGAGTCAGCTTCTGTAGGGT AAGTGTTCACAGCTGGTGCAGCTCTTTGGGAAACCTAACCTCCCAGTGAGCTGAGCCCCTGGTGCGGCCGCCACGCTTGCTTCTGCCCCA CAAGGGCAGTAAGCACAGGACTTCTGGATGGATCTGGGAGCCTGCCCCTTGGGATTTGGCAAAACTTCCCATCTCCTTAGCTACCTGTCC TTAATCTTATCCCTGACCCCTCGAGGGCTTTCAAGATAGCCTCTGTTAACATCACTACCCTCTGCCTGTGTAGAACTTTATAGAAAGGCT AGGCAAAAAATGAGACCCAGAGATATGGAAGAAACTGGCCAAAGAGGGGAAAGTGGGCTATTTCTTTTTTTTTTTTCTTTTTTTTTTCTG AGACAGAGTCTCACCCTGTTGCCCAGGCTGGAGTGCAGTGACAGCGATCTTGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTC TTCTGCCTCAGCCTCCTGAGCAGCTATGACTACAGGTGCCCACCACCATGCCTGGCTAATTTTTTTATATTTTTATTAGAGACAGGGTTT CACCATGTTAGCCAGGTTGGTCTTGATCTCCTGACCTTGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCCACCGTAC CCGGCCAGGCTATTTTTTTGTTTTGTTTTTGTTTACTACTGTATTGCTTTTCTCTTTTTCATATTTATTGAGCACCTACTATATGCCAGT CACCATGCTAGATGCTTTAGTAACATGAAGGTTTCAAACTAAGAAAAGCTCAACAAAGAGCCCTTTAGAAAGGTAACAGTTTTCCTGTGT ATTGGGGGAGTGGGTCTCATAAGGTTGTATGATGAGAAGCGCAAGTAATTGTTTTGTTTTTTTTTTGAGACAATGTCTTGCTCTGTCGAT CAGGCTGGAGTGCAGTGGCGTCATCTCAGCTCGCTACAACCTCCACCTCCTGGGTTTAAGTGATTCTCTGGCCTCAGCCTCCTGAGTAGC TGAGATTACAGGCACGCGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGTCAGGCTGATCTTGA ACTCCCGGCCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAACTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCTGGCTAAGGTTC ATTATCCCCATCTTTCAGATGAGGAGGCACACAACTCTCCCCAGATCCCACGTCACAGAGAATGCAGGTCTGAGTCTGTTCCTTGAGCTC AGGGTCTTGGCAATGGTGATGCTTTGGAGCTGCAGAATCCTCTGTTGGGGATGGGGCTGCCCTGTGCATTATAGTACGTTTAGCAACATC CCTAGCTTCCACCTACTAAATGCCACTAGCACTCCTTCAGATGAGACCACCAAAAATGTCTCCAGATGTTACCACATGTCCCCTGGGGGG TAAAAGTGCCCCCGTTGAGAGCACTGGCTCTTTTCTTCACAGTCCTGACCTGGTGGCCTGCACAGGCCACTTCTCCGAAGTGTTTCAATG CACTCTCTGCCCTGGGTACCTTGGACACAGCACCCTGGCCCAGAGAGGTTGGCTGACTTGCCTGAGACGCTGCTTCCTGGGAGACGCAGT AGCATCTTTCCTTTCTGTTCTGGTTATCTTTCTTAGTTCTTTACCACCTTATATTCCCCATGACAGGTGTGTTTATGTACACACATCTGC CTCACTCCACTCAGCTCCCTGTCAGGTTTCCTGCCAGTCTGTCCCTCTTCCTTCAGGCTCAGCTACGTCCTGCACAGACAGTACCACTGC ACATACCTGTGTGTGCCCAGCGGTGGACCCACCTCCAAAAGCAGCCAGTGCTGACAGCAGAGAGCCTTCCACACTCAAGTCAGGCCAAGC AGGAATCGCTACCTGCCTGTCATGACCACATTCTCAGTGAACATTGACAAAGCCCCCTTAGCAGCTAATTAGCCCTGCCGTGCGCTAGGG ATGCAATTTCTCATCTGGCAGTGCGCCACACTCCTGCCTCCCTGCCCAAAGGACGTAGTGGCTGCTGCTGATCGTCTGCACTGCTGTTCC AGGGGCAGGAGGTTTGCTGCAAATCAGGTACCCCCAGCTCAGTGAGCAGAACCAGTCCAAGGTTGAGTGAGGAGAAGGGCAAGAAGGGCA GGCACAGCCGTGAGTATGTTCTGGGGCTAAGTAACCATGAGATCAGCCCAGAGACCTTGCACAGTTAGGCAGGCCTGGACTTCTCGCCCT TCCCCTTGCAGCTTCTGCTCTCCCAGCTAGGGACTGAGGAAAGCCCTGCTTCTAGATGCCATGTGCTGCTGCCTGGCACGATAGGTACCC ATCTGTCCTTGGGGTTCCTGAGCCTGGAGAGCGGGCTTTGTGAGCACTGGTGCCTCACCTGCCTGGCTCAGCTCTGCAGCCACAATATAT GCTTAATACCTATTTGTTAAATGATTGAAGACTTGACTGCCATTCAGTACAGAGAATTAGCCAGGTGAATAAACAGGATGTGTCATAGAG GTTCTAGAATTGATCATGACCCTTTCTGTCTCATTCCTGACTTCTAATACCGTATATGCCAAATGGGGTTCTGCTGTGATTTAATTTCTT AAGGACTGGGTTTATCAAAAGTCCCTCCTGATCTAATCCTTTCCTCTAGGAAGGCTTCTCCTTTCTTCATCTGTCCTAAGTGCATGGTCT TCATCTCCTGGGTGGTCCAGACTAGGTGGCACTGGGCCTGCAGGCCTCTAGCTGCTCAAGGATGGCCCTGTCTGCATGCTTCCTTTCAAA AGCTAGCATAGAAAGGAGGGCCCAAGGTGAGGAAATTTGTCCAAAGTCACCCAATGAGTCGCAGGAAGGGCTAGAATCTGGTTATCTGGA CCGTCCTAGAGCACTTTCACAGTGACAGCCGGCTGGAATCAAGTTTTCATTTAGAAAAATGGCTAGAAGTTAGGGCATTGCCTGCAGCCA CTGAAAAGCAGCTTTAGGAGCAGATGTCCACGTAATAGAAGGAGATGGGCTAGGGCCTGCCACGGAAGCCAGCAAGCGCGTGGGAGCTGG GGGAGGAAAGGAGCAAAAGGCAAGAACAGGCAGTATGTCCGCGGTGCCCACAGTGCTGTGGGTACAAGCAAGGGGAAAAGAGCCCATGGT GTGCAGAAAACCATGCGTCATGATTCTTATTTCCTGCTCGCAGCTTTGACTCTCTGCCTCATCTCTTCCTGGAAGTGTCTTGGAAGTTAG GCGACTGCACAGGGAAAGGTTCGCTGCAGTGCTTGCAGGCCTGCACCCATTTATTCATCCGGTGGATATTTGCTGGGTGCCCGGCCTGGG GATCCATGGTGAGCGAGGAAGGCATGGTATTGAAGTGGTATGCCTGCATGACCTTGGCGGGGGCGCATGGCATAGAGAGGACAGGCTTCA GAACAGGCAGGCAAGGGCTGAAATCCTATCTCTGCCACCGAACAGCTAATGACCCCAGCAAGCAATTTCACATCCCCGAACTTTCCTGTT TCCTCATGTGTCAAATGGGGATGATCTCGAGACGACTCTCCAGAGTAACCACGTGAAGCACCTAGCACAGGGGCTGACGCAAACAGCTGG GCATCGGAGGAGCCTCCAGGGTTGTGACCTCCAGTGGCTTATTTTCCTTTTGGGATCTTCTCTCCTAGATCCTCCCCTTTAATTCCCTGT GAAATTTACCACTTTCATATTGAATCGTTGGCACACAGGGCTAACTGCTTGTTCACCTGAAGGAAGCTACAGAGTTCAGGTTTCTTTTTT CTTTCTTTCTTTCTTTTTTGCTTTTTTAAGATGATCTTGCTCCGTCACCCAGGCTGGAGTGCAGTGGCGTAATCATGGCTTCCTGCAGCC TCAAACTCCTGGGCTCAATGAGTTCCTTGAGATCTTCCATCCTCAGCTTCCCAAGTAGCTAGTAGTAGTAGTGGCTTGCACCAACGCTCC TGCCCTAATTTTCAATATTTTTTTGTAGAGATAGGATCTCACTGTGTTACCCAAGCTAGACTTGAACTCCTGGCCTCAAGCGATCCTTCC GCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATTAGCTACCACACCTGGCCAAGGCCCAGGTTTCGACAGAAAGGGAGAGAAAACCTG CCAGAGATGCCATTTCGGAGCCACTCTGCTTGGCAGGGACCTGTGTTCCCCTCATGCAGGTTCATCCTTAGAGGGCTGCGGTCTTATCTG GTTGTGCAAAAGTCCCACAACCTTTCTGGATTGATAGTTTGTGGTGAAATAAACAATTTTAGTTTGTTTGGAGAATCTTTTGTATACAAA ATACAAATAAAACCTAAATCAAAGAAACAGAGCATGTCCGGAGAAGTCTGCCAACCCTTCTCCAGGCCATGGGGCTTCCCAAGCCAGGCC TGTACTCCTCATGTAGATTCCACACCCCGCCTTGATGTCTTTGGCTTTCACACTAGTGACTATAGCCTGGTGGGACGGGGTCTAGGGGCC ACAGTCCTGGTCCTGCGCAGGTGGCCCTGGAGAGAAGCCTTGGAGAACTTGGAGAAGCCCACGCGGCTGGCAGCATCATGGTGAGAGGCT GACACCTTGTGGCTGGCTGGCAGCATACGTCCTTCCTCCCCTAGGTCAGCTAGACGGCCAAAGCAGGGATCTGCAAGCTCCTTCTGTGGC GGGCCAAAAAGTGAACATTCAGTGTGTCTGTTGCAGCTACTGTCATAGCACTGAGGCACCCCTAGACAGTACAGAAACAAGCAGGTGTGG CCATGTTCCAGTGAAACCTTATGAATACTGAAATCTGAATCCATAATTTTCATGTATCACAAAGTAGTAATATTCTTTTAATATGCAAAA ACCGGCCAGGTGCGGTGGCTCATGCCTGTGACCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCGAAACCA GCCTGGCCAACGTGGTGAAACCCTGTCTCTATTAAAAATACAAAAATTAGCCTGGTGTGGTGGCACATGCCTGTAATCCCAGCTACTCGG GAGGCTGAGGCGTAGGAATTGCTTAAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTTCAGCCTGGGCAACAGA GCTAGACTCCATCTCAAAAACAAACAAACAAAAAAACAAAAGCAAAAACCAGTCTTAGCTCACAGGCTGTGCCAAAACAGGCAGTGGGCT GGATTTGGTCCTCAAGCCTGGGCTTGCTGACCTCTGGCCTAGGACACCTCTCCTTTATGCCTCCGCTCCCAACACGGACTCTCAACTCTC ATGTTTACCTTGTCATTGTTCTGTCAAGAGGAATTCACTAGTCTCACTCCTCCAACCAGACCGCTGCCACTAAGGCTTCTTCTGAACAGA AATTCTGGATTTGTTCTCACCCATTTCATAAATGTACATAAGCACCCATCAGGTGCCAAGCCCTGTGCTGAGATGCCTGCAGAGCCCAGA GTTTTCACCAACTTTTTTTTTAAGAGATGGGGGTCTCTGTTGCCAGGTTGGAGTGCAATGACATAATCATAACTCACCGCAACCTCAAAC TCCTAGGTTCAGGTGATCCTCCCGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACCACCCTGCCCAGCTAATTAAAAAAAAAA CTTTAGGGATGGGGTCTTGCTATGTTGTCTAGGCTGGTCTCTAACTCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTG GGCTTACAGATGTGAGCCACTGCACCTGCTCAACATTTAATTTTTTCATTCATTCATTCGTTCATTCATTTGTTCAAACGAACTTATTGA GAACTTACTGTGTTCCAGGCACTGTGATAAGATAGACCTGGCCTTTACCTTCAAATGTTCAGAACATGGTTAGGAAGATGGATACTGGGA GGCAAGTGTTCTGATGGGAAAGCACAGCATGTAAAGAAGCCCAGAGGAGGCACTTAACCTGGGGGAGAAGAACAGGGTAGGCTTCCTGGA GGAGGAGGTAATCTCTGAGCCGATACCTGAGGAGTGAATGGAGGAGGGGACAATGAGGCAAGGCATTCCAGGGAAAGGTCCAGAGCCTAG ACAGAACTCTTTTAGGAGAATTATGAGAATCACAATTATCGAGGACACAGTGAAGACTCAGATAACTCAAATATAGGTTTTGCCCGCAAA GCCTTCCTGTCTGGTGGGTGAGACAGTCTACAGCAAGCTGCTCCAAGGATATGGAGAAAAAAGTTTTTCCTCTGGCCTTGTAGGATTGGT TATTACTGAGCCTGGAGTACGCAAAGGCCAGCGAGTGCTCCTAAGGCAGGGAGGGGGCTGCCTTCACTATGGGTGCTCAGGAAATCTGCC AGGGGAAGGGAGATGTGGGCCTGCCTCGGCTGCAGAAACCCCTCAGAGGAGGAGGAGGGGCTTGAACTGAGCTTTGAAGAAAGTGTAGAC TTGGGGACAGGCAGAGGAAGAGGGGGCATCATAGGCAGCAGAAACCACATGGACAAACTCTCTGCCGGAGAATGGGCATGGCCGGGCTGA GGGGTCCCTGGACAGGAACCAGCCTTCCCTATGCACCTGCACCCGTGAGTCTCACAACAGCCCCAACAGGCAAGTGTTATTTTCCTCAAT TCTACCAATTAAAAACTGACCTTGGGCAACTGCTTAACCTATCTCTGCCTTACTTTCTTCATCTGTATCTACCTCAGAAAGTTACTATGA GGACTGAATAAGCTCATACATATACAATGCTTGGAGCAGAGGCTGGTACTAGAGCTGGCTTCATGGGCATGAAACCTGTGAACACAGAAC CCCATGCTTTCATTTTCCACTTAGTCCTGCCTGGCATAGTATGCAGTTTTTTTAATTTGAGATGGAGTCTCCCTTTGTTGCCCAGGCTTG AGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTGAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTA CAGGTGCGCGCCACCATACCCAGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGCCATTTTGGCCAGCCTGGTCTTGAACCTCTGA CTTCCATGATCCACCTGCCTCTGCCTCCCAAAGTGCTGGGAGGATTACAGGCATGAACCACTACGCCTGGCCTGGTATGTGGGTTAAAAT GTTAGGTTTTATCATTATCTTAGGTGGAGAATAACAAATCCGATTCAATATATTCATTTTAGAAACGAGGAAACTGAAGCTTAGATAGTT TGTGTGACTTGCAAAAAGTCACGCAGCAAACAAGCTGCAGAATGAAGGGTGGAGATGGAGAGATAGAATTCTCATCTTAGAGGTGAAAGT AGGATAATGACCCAGCTGAGCTTGCTGAGTCCTGCGAGCGTCGCACGCCCCCAGAGACAACATAAGGAGAGAAGTGCAGACAGATTCCTT TGAAGGAGCTTAGAGAAAGAGATGGTAGGGAAAAGAGCATGAACAGTTGTAGAGGTAGGAGGAAAGCTGGCTATTTGGGGAAGCAAAGAA AAGATTCTCAGAGTAAAACGTATTGGTGAAGCCATGGAAACAAGGACTGAGAAAGTCTCTTGGATCTTGGCCACAAAAAGGTTATAGATG AGCTTAGAGAAATGAATTTCAGTAGAGTTAGGGCTAGAAGCCAGGTTCAGAGAGAGAAAACGAGAGAGCATTCCTGGTGGTGGAGATGGC CGCAGGCCATTATTTAAAAAGCTAGGATAAGAAAATAGAGAAGAAAGGGAAGGAAGCTATTTGAAGGGAGTGGGAGAAAAGCCAGATCTC AGTTGGGACGTGGAGGAAGGACCACCAGAGGCAGTAATTTAGCCGGAAAGAGGTGTATTTCTTTCCTTGAGTTTATAGGGGGTAAAGAGG ATGGGGCTGAGATACTAAAGACTACGAGGACAACTGTTCATTGAGGGCTGGTCATCTCCCCAGCTGCACTGTGGGGTTCCCAAGTCAGAC ATCCCAGAGGCAATATAGCAGCGTGGACAAGAGCTTACTCGTTGGAGTCAGACCGCCTAGGTTCAACGATGGGTTAGTTAGCCCTTCAGT GCCTCCATTTTCCTATCTAGAAAATGTGGATAACAATGGTTGTTGTGAAGATTAACAGCCATAATCCACGTAAAGCCCTCAGTACAGTGT ATGACACACAGCAAGTGTCCACCAAAGGGTAGTTATTATTAACCATAATCCTGGTTCTCTTGTGAGCTGCCTCCTGTGTGTCTAGCATTG GCCAGCACACATGAGGGGGTCCAGTGTTTGCTGCTTAACTAAGTAGCTTCTCAGGAAGTGTGGTCATAAAAAATGATAGGTGATTTAGAA GGTGAGACAGACACAAGGGATGTGTTGCACAGTAAATGCTCCCAGACATGCAATAAATGCTTATAAGCATGCCCTCTGTAATCAGCCCTC TTTAGAGAGTTTCCCTGCCTCATTGCTCTTGGTCTTTGGCAATGGCTACACCCACTGCCCAAGCAAGCAGTATCAGCTGTCAGCTGTCCC CTTGTCTTTTGGATCAGATTCCTTTACAGGGATCTTCCCATTGTTATAAGCTTCAAGAATTGGAGAATGCTTAATGAACACTTCCAAATT CTTCATAGCTATGAGGGGCCAGTGCAAAGGGCGGAAGGAGTTCTTCTGTGTCACAGAAATTAGAGCTGGAGCAGATCCAGCTTGCTATCC CCCCTTCCCCCAGCTTGTGGGTTATTGCAGAATTGTTCACAAAAATTCCCATTGCCTTGGAATTTGTCCAAGCCGAGGGCAGGGATCACA ACACAACCTCTCAAGGGAAAAAAGGAAGGCCTGTTGCTTGAGATGGCTCAGAGCACTTTTGGTAGCCAGCCAAGGCAGCTATCACTCATG AAATCTGCCTTCCCCTCCAGCAAAAAGCCAACTGTATAGAACACCACATATAGAGCGCTAAGAATAGCACAGCGCTCCAAGAACATAGTG CACTTGGCCTGCATACAAGTGTGCAGGGCTTAACGAGTCTTTTTACTCTGAAAGCTGGGTGGGTTGGAACAAACAAACAGAAAAATATTT TCCCCAAGTAGCATGCAGAGAGGAAATGAGAGCAAGCACAAGAGAGCACCCTGGCATAGCATTCTCTGACCTGGGCTGCCTTTTCAGGGT ATGAGTTGATTCCGCAGGCACCAAGGCATGCCTGTAAGCCCTACAGGGCAGACGCCCTCACCCCAATCATTGGCTTAACATTCACACCAG GCTGAGTAAGCCCCAAAAGTCCTGCCATTGGCTCTGACAGGAATTGAAACCCATCTTCTCCACAATAAATATTTGATTGACAGATTGGCT TCCTTCCTATAAGTATAGAAAGCGAGGGCAGGTTCCATCCAAAGCCGCAGTTCTGGGTGATGAGAGCTCTGAGAGCCCAGAAAAGACCCT GAACCACATCCCACTGTTTGTTGGAAGAAGAAACTCATTTGTGGGTCTGTTCATAAAAGAGTCTGGGAAGATAGTCTCCTTAACAGTGTC TGGATGTAACAGACTATGGGCGGCTTTTACTTTATAACTTTCTATATTGTCTGAAATACAGAATATTAAATATTGAGTTAATATTATATT TACTCAATGTTACTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTATTGCCCAGGCTGGAGTGCAGTGGTGTGGCTCACTGCAGCCTTGAA CTCCCAGGCTCAAGCAATCCTCCCACCTCAGCATCCCAAGTAGCTGGGACTGTAGGCGCAGGCCACCATGCGCAACTATTTATTTTCTTT CTTTTTGTAGAAATGGGCTCTGCCTGTGTTGCTCTAGCTAGTCTCAAGCTCCTGGCCTCAAGCAATCCTTCCGCCTTGGCCTCTCAAATT GCTGGGATTACAAGCATAAGCCAATGTGCCTGGCCTCAATGTTACTTTTATGATCAGAAAAACGGCCATCTTATTTGGAAATTATTTTCC TATTCTCAAGTGGGCAAATAGGAGAAGGTTTCAGGCATTTGTTTTGTCTCTGGGAGGGAAGGCACAATGAGGTGGAGTGGACAAATTGCT GAGGCCTTTATGGACAAAGATTCTAAGAAGAACAGGCTTTGGCCATCTCTGGATATTCCCATTCTGCTCCCTGCCACCAGAGAGCAAATG TCGTAGGTCACCACACATCACCAGTCTCTTGCCTAGCTAACCGTAACTCATTCTTTAGTTCTCCTTGAAGGTGTCACTTCTTCCAGGAAG CCATTTCTGTCCCTCCCGAGATGGAGTCCCATGTCCCTACCATTTGCTTCCAGGGCACCTTCTCACAGCACTGCATCATGGTTATCTGCT TATCTGCTGGACACCCCTACTCGACTGAGGTCCTTGAAGGAAGAGAGAGTGTATCACTCATCTGCATAGCCTTTGTAACTTAGTAAAAGT GCCTGACATGCTCACTAAACATTTACTGAGTAATTATTTATTTGGGGGCCTTTTACGATCAGAACAATGTGAAGGACACAAAGATGAAAA AGAAACCATCTGCTTCAAGGTACTTACAACTGAAATGTATCAAACAATTACCCAGAAAGTCAAGCACCAACTTAAGTGCTAAAATAGGGG TCCAAGCAACCAACTTTGAAGATTAGGAAGGTTTTAGATTCTGAATGTTTCTCATTCATTGTGTTTTTGAGTTCAGAATCCCCATACTGG AAGGCTAATATGGGGTATGTGCATACAATTTTAAGGACTCACGTTCTTACAACCTATATTAGAATTTGACGCACGATCTTTCTTCTGTCC TTCTTGCAGTTGCCCTAGGAATACATGCCACTTACTCTTAATTGACGTTTATGAAATACCTTGGCTTCATTTGCTGAAAGGCTCTAAGTG TTGAGCATTGTTACTATGTTACAATGGTTGTTTTATTATTAAAGCAGTGCCAAGGAGGTTACACAACAGCTTGGATCAGGAAGTGAAACA AGGGCGGTGATCCCACTGAAGCTACAGGGGATGGGGATTTGGGACGGTAAAATGTTAATTACCCAAGATGGAATGTGGGCTAGAGTCCAG CGTTGTGCTCCTGGAGATCATTTCGGTCGCAAAAGCTCACTGGCAATGGGTCCTAAGCGTCCTGCCCTCCTCTGGCTGAAATGTTGGATT CACTTCGATGAATGCTGCTATAGGGAAAGAACCCAGTGGCCACCAGCCAGGAGCACACGTCTTGCTCAGCATCAACTATCCTGGAAGATT |
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FusionGenePPI for RTCB_FAM83F |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RTCB | TP73, SIRT7, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, CAND1, DDX1, C14orf166, FAM98B, C2orf49, CA9, FN1, AICDA, ABCF1, YBX3, DHX9, EIF2B2, EIF2B3, FLII, KRT18, LRRFIP1, HNRNPM, IGF2BP3, ILF2, MRE11A, NMT1, POLR1C, PRKDC, QARS, RFC2, RFC4, RPL26L1, RPL27, FUS, CUL7, OBSL1, CCDC8, BMI1, ESR1, RPS6KB2, HNRNPA1, FBXW11, UNK, CCDC22, DPH2, HNRNPH1, KIAA0368, MTMR12, NDRG1, PPP1R8, RAVER1, DNM2, EEF1A1, PAFAH1B2, SEPHS1, UFD1L, WDR12, NTRK1, APPL1, CRK, XPO1, HNRNPU, NPM1, RPL10, MATR3, SNW1, CDC5L, NANOG, POU5F1, CRBN, RFX3, HDAC1, XYLT2, MTA2, PTOV1, CYLD, COX15, DLD, HSD17B10, SOAT1, VDAC1, TRIM25, G3BP1 | FAM83F | MME, ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RTCB_FAM83F |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RTCB_FAM83F |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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