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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32322

FusionGeneSummary for RTCA_RASSF8-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: RTCA_RASSF8-AS1
Fusion gene ID: 32322
HgeneTgene
Gene symbol

RTCA

RASSF8-AS1

Gene ID

8634

100506451

Gene nameRNA 3'-terminal phosphate cyclaseRASSF8 antisense RNA 1
SynonymsRPC|RTC1|RTCD1-
Cytomap

1p21.2

12p12.1

Type of geneprotein-codingncRNA
DescriptionRNA 3'-terminal phosphate cyclaseRNA terminal phosphate cyclase domain 1RNA terminal phosphate cyclase domain-containing protein 1RTC domain-containing protein 1RASSF8 atnisense RNA 1
Modification date2018052320180329
UniProtAcc

O00442

Ensembl transtripts involved in fusion geneENST00000370128, ENST00000498617, 
ENST00000260563, ENST00000370126, 
ENST00000545729, ENST00000500276, 
ENST00000502069, ENST00000545226, 
ENST00000546134, ENST00000542086, 
ENST00000535436, ENST00000500102, 
ENST00000537801, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RTCA [Title/Abstract] AND RASSF8-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA532445RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000370128ENST00000545729RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-5UTRENST00000370128ENST00000500276RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-5UTRENST00000370128ENST00000502069RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-5UTRENST00000370128ENST00000545226RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-intronENST00000370128ENST00000546134RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-intronENST00000370128ENST00000542086RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-intronENST00000370128ENST00000535436RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-intronENST00000370128ENST00000500102RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
3UTR-intronENST00000370128ENST00000537801RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000545729RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000498617ENST00000500276RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000498617ENST00000502069RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000498617ENST00000545226RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000546134RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000542086RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000535436RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000500102RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000498617ENST00000537801RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000545729RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000260563ENST00000500276RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000260563ENST00000502069RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000260563ENST00000545226RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000546134RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000542086RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000535436RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000500102RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000260563ENST00000537801RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000545729RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000370126ENST00000500276RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000370126ENST00000502069RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-5UTRENST00000370126ENST00000545226RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000546134RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000542086RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000535436RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000500102RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+
intron-intronENST00000370126ENST00000537801RTCAchr1

100758137

-RASSF8-AS1chr12

26105975

+

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FusionProtFeatures for RTCA_RASSF8-AS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTCA

O00442

RASSF8-AS1

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of actionof the enzyme occurs in 3 steps: (A) adenylation of the enzyme byATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic endproduct. The biological role of this enzyme is unknown but it islikely to function in some aspects of cellular RNA processing. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RTCA_RASSF8-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RTCA_RASSF8-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RTCA_RASSF8-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RTCA_RASSF8-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource