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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32319

FusionGeneSummary for RSU1_PARG

check button Fusion gene summary
Fusion gene informationFusion gene name: RSU1_PARG
Fusion gene ID: 32319
HgeneTgene
Gene symbol

RSU1

PARG

Gene ID

6251

8505

Gene nameRas suppressor protein 1poly(ADP-ribose) glycohydrolase
SynonymsRSP-1PARG99
Cytomap

10p13

10q11.23

Type of geneprotein-codingprotein-coding
Descriptionras suppressor protein 1ras suppressor protein 1 variant 1ras suppressor protein 1 variant 2ras suppressor protein 1 variant 3ras suppressor protein 1 variant 5rsu-1poly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform
Modification date2018052220180523
UniProtAcc

Q15404

Q86W56

Ensembl transtripts involved in fusion geneENST00000377921, ENST00000345264, 
ENST00000602389, ENST00000464074, 
ENST00000402038, ENST00000492350, 
Fusion gene scores* DoF score6 X 4 X 6=1447 X 6 X 4=168
# samples 67
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RSU1 [Title/Abstract] AND PARG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePARG

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-7716-01ARSU1chr10

16794538

-PARGchr10

51051678

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377921ENST00000402038RSU1chr10

16794538

-PARGchr10

51051678

-
5CDS-intronENST00000377921ENST00000492350RSU1chr10

16794538

-PARGchr10

51051678

-
Frame-shitENST00000345264ENST00000402038RSU1chr10

16794538

-PARGchr10

51051678

-
5CDS-intronENST00000345264ENST00000492350RSU1chr10

16794538

-PARGchr10

51051678

-
Frame-shitENST00000602389ENST00000402038RSU1chr10

16794538

-PARGchr10

51051678

-
5CDS-intronENST00000602389ENST00000492350RSU1chr10

16794538

-PARGchr10

51051678

-
5UTR-3CDSENST00000464074ENST00000402038RSU1chr10

16794538

-PARGchr10

51051678

-
5UTR-intronENST00000464074ENST00000492350RSU1chr10

16794538

-PARGchr10

51051678

-

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FusionProtFeatures for RSU1_PARG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RSU1

Q15404

PARG

Q86W56

Potentially plays a role in the Ras signal transductionpathway. Capable of suppressing v-Ras transformation in vitro.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-79110_133199278RepeatNote=LRR 4
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-79135_156199278RepeatNote=LRR 5
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-79158_179199278RepeatNote=LRR 6
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-79181_202199278RepeatNote=LRR 7
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-7941_63199278RepeatNote=LRR 1
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-7964_85199278RepeatNote=LRR 2
HgeneRSU1chr10:16794538chr10:51051678ENST00000345264-7987_109199278RepeatNote=LRR 3
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-68110_133199278RepeatNote=LRR 4
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-68135_156199278RepeatNote=LRR 5
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-68158_179199278RepeatNote=LRR 6
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-68181_202199278RepeatNote=LRR 7
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-6841_63199278RepeatNote=LRR 1
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-6864_85199278RepeatNote=LRR 2
HgeneRSU1chr10:16794538chr10:51051678ENST00000377921-6887_109199278RepeatNote=LRR 3
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-68110_133146225RepeatNote=LRR 4
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-6841_63146225RepeatNote=LRR 1
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-6864_85146225RepeatNote=LRR 2
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-6887_109146225RepeatNote=LRR 3
TgenePARGchr10:16794538chr10:51051678ENST00000402038-814610_795299492RegionNote=Catalytic
TgenePARGchr10:16794538chr10:51051678ENST00000402038-814726_727299492RegionNote=Substrate binding
TgenePARGchr10:16794538chr10:51051678ENST00000402038-814869_874299492RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-68135_156146225RepeatNote=LRR 5
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-68158_179146225RepeatNote=LRR 6
HgeneRSU1chr10:16794538chr10:51051678ENST00000602389-68181_202146225RepeatNote=LRR 7
TgenePARGchr10:16794538chr10:51051678ENST00000402038-81410_16299492MotifNuclear localization signal
TgenePARGchr10:16794538chr10:51051678ENST00000402038-81476_83299492MotifNote=PIP-box (PCNA interacting peptide)
TgenePARGchr10:16794538chr10:51051678ENST00000402038-8141_456299492RegionNote=A-domain


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FusionGeneSequence for RSU1_PARG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_392aa
MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKH
LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALTLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
QLKELHIQGNRLTVLPPELGTEQYSEYTGTAETTRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRP
GVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVTFTFGDSELMRDIYSMHIFLTERKLTVGDVTKLLLRYYNEECRNCST


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_1176nt
ATGTCCAAGTCTCTGAAGAAGTTGGTGGAGGAGAGCCGGGAGAAGAACCAGCCCGAGGTGGACATGAGTGACCGGGGCATCTCCAACATG
CTGGATGTCAACGGCCTCTTTACCTTATCCCATATCACACAACTGGTCCTCAGCCATAACAAGCTAACAATGGTGCCACCGAACATCGCA
GAACTGAAGAATTTGGAGGTGCTCAACTTTTTTAATAACCAAATCGAGGAGCTGCCCACACAGATCAGTAGCCTTCAGAAACTCAAACAC
CTGAACCTTGGCATGAACAGGCTGAACACTTTGCCACGAGGCTTCGGCTCCCTGCCAGCTCTTGAGGTTCTGGACTTGACGTACAACAAC
TTGAGCGAAAATTCTCTTCCTGGAAACTTCTTCTACCTGACCACCCTGCGTGCACTCTATCTAAGTGACAACGATTTTGAAATCCTGCCG
CCAGATATTGGGAAGCTCACAAAGTTGCAGATACTCAGCCTTAGGGATAACGACCTGATCTCGCTGCCTAAGGAAATCGGGGAGCTTACC
CAGCTTAAAGAGCTCCACATTCAGGGGAACCGCCTCACCGTTCTGCCCCCAGAACTAGGTACTGAGCAGTACAGTGAATACACAGGCTAT
GCTGAGACATATCGTTGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGGCAGCGGCGCTGCACTGAGATCGTTGCCATCGAT
GCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAAATGAGACGCGAGCTGAACAAGGCTTACTGTGGATTTCTCCGTCCT
GGAGTTTCTTCAGAGAATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCCAGGTTAAAAGCCTTAATA
CAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTCACCTTTGGGGACTCAGAATTGATGAGAGACATTTACAGCATGCAC
ATTTTCCTTACTGAAAGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGATACTACAATGAAGAATGCAGAAACTGTTCCACC
CCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTCGAGTCCTGTGCAGAGACCGCTGACCATTCAGGGCAAAGGACAGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_2539nt
GGGCAGCTGGAGTGCGTTCTGCCGAAGCTTGTGGTTGCACGCCCATCGTCTTAGGGGCTACCTTCCGTGGTGAGTGTGTGCGGTGTTGCA
CTTGGGGTTGCTTCTCGCTGCGTGGCCGCAGCGGGGCTGAACCCTTCCCACTCCATCCCCTCCCCGCACCCGGACCAGCCCCTGGGACGC
CCTCGGACGCCCACCCGCTCCAACCCTGGGGAAGCCTCAGAGTGGCAGCGAAGGCCTCTTGCCTTTCCGCCTCTGCGCTTGCTGTCATCG
CCCACGTGCTTTGTTGTTGTTCGGTGCAGACCATGTCCAAGTCTCTGAAGAAGTTGGTGGAGGAGAGCCGGGAGAAGAACCAGCCCGAGG
TGGACATGAGTGACCGGGGCATCTCCAACATGCTGGATGTCAACGGCCTCTTTACCTTATCCCATATCACACAACTGGTCCTCAGCCATA
ACAAGCTAACAATGGTGCCACCGAACATCGCAGAACTGAAGAATTTGGAGGTGCTCAACTTTTTTAATAACCAAATCGAGGAGCTGCCCA
CACAGATCAGTAGCCTTCAGAAACTCAAACACCTGAACCTTGGCATGAACAGGCTGAACACTTTGCCACGAGGCTTCGGCTCCCTGCCAG
CTCTTGAGGTTCTGGACTTGACGTACAACAACTTGAGCGAAAATTCTCTTCCTGGAAACTTCTTCTACCTGACCACCCTGCGTGCACTCT
ATCTAAGTGACAACGATTTTGAAATCCTGCCGCCAGATATTGGGAAGCTCACAAAGTTGCAGATACTCAGCCTTAGGGATAACGACCTGA
TCTCGCTGCCTAAGGAAATCGGGGAGCTTACCCAGCTTAAAGAGCTCCACATTCAGGGGAACCGCCTCACCGTTCTGCCCCCAGAACTAG
GTACTGAGCAGTACAGTGAATACACAGGCTATGCTGAGACATATCGTTGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGGC
AGCGGCGCTGCACTGAGATCGTTGCCATCGATGCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAAATGAGACGCGAGC
TGAACAAGGCTTACTGTGGATTTCTCCGTCCTGGAGTTTCTTCAGAGAATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCT
TTGGGGGTGATGCCAGGTTAAAAGCCTTAATACAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTCACCTTTGGGGACT
CAGAATTGATGAGAGACATTTACAGCATGCACATTTTCCTTACTGAAAGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGAT
ACTACAATGAAGAATGCAGAAACTGTTCCACCCCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTCGAGTCCTGTGCAG
AGACCGCTGACCATTCAGGGCAAAGGACAGGGACCTGAGGAGCCGAGCGAATAGCATCTCCTCCCACCTCCCACCAGAGACGTCCTGTTT
GAGCTGTCAGGTGTAATATATGAATTGACTTAAGTTAATATAAATGTGTACATAATCCACATTTGTAGTCAAGGACGCAATCTCTTCCAC
ACATGTGCAGTTGTCAGTTGGTACATCTAAACTCCCTCCATCCTGACTCACGTGGACTTAGATATGTTTTGTTTCTATTTTCTTCTATTT
CAGTTTTTCATTCTTTGATGTTTATTTCTTTTGTCCATCAGATCTCTTGTGAAATCCCATGGAAGGTTGTGCTCAGCCTGTCGGGTCTCT
TTCTTCCTGCCCATATATTATACCAGTTGCTTCTGCAGCCCGCAGATGCCAGCGATGCCAGGAAACAAGTTGAAATCCAGGAATCTCTTT
AACTGATTTTGCTAAAAATCTCCCTGTGAGCCTTCCACTCAACTCTTAATATGCTTGCATTGTTTAAGTTTTTAAATTCTGAAAATTAAT
AATTAGGGTTTTTTTCATATGTGTTGCATAATGCAAACCTCCTAGGTTAAAATAGTTTCTTTATTTAAGATAGAATAATTTCCAGAAATT
GTACTTTTGAGGTATCATTTTTATCTGTAATGGTTTGTCTGTCTTTTTTCCTCTGATCAGTATTTTTTTATACCAGTTTTGGAGACTGGC
TGAGATGAAAGGAAATGTGGAATAAAAGGAGGTTTTCCTGATGTGGTGTAAAGAAAACAGATTCAAGAGAATTGAAGATTTTTTTTGTTT
CTTGGTACTTTTTTCTTTTTAAATTAGGACTAATGTTTCTTTTGTGGTGCTTGAGGCATATTCATATAACCAAAGTTTGAGAACTGGGAA
CTTCATGCTGATTTGTACATATTGAAGTTTCTCTGGTATTCAAAGGTTATATAGTGAATGAATTTTCATTAATAAATCACTTTGTCAGAA
ACTCCCATATCATCTATATTTTATATATGTATATATAAACGTATGCTCTTTAAGTGTGTCTATATGTGAGCACATAAAATCTAAATAAAA


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FusionGenePPI for RSU1_PARG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RSU1ACP6, ILK, HGS, GSK3B, ELAVL1, LRRK1, APP, VCP, FN1, LRCH3, FAM114A1, PARVA, PPAT, SEC24D, SUGT1, LIMS1, PARVB, PARVG, CBS, HNRNPA3, NDUFA8, NTMT1, PFKP, DAZAP1, DHX15, FLNB, HADH, USP3, TIAL1, TKTPARGCASP3, KIAA0101, NTRK1, HIST1H2BG, BRCA1, BARD1, ATF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RSU1_PARG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RSU1_PARG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRSU1C0029456Osteoporosis1CTD_human
HgeneRSU1C0263454Chloracne1CTD_human
TgenePARGC0007621Neoplastic Cell Transformation2CTD_human
TgenePARGC0752351Embryo Loss1CTD_human