	FusionGeneSummary
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	FusionGeneSequence
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Fusion gene ID: 32319

FusionGeneSummary for RSU1_PARG

Fusion gene summary

Fusion gene information	Fusion gene name: RSU1_PARG
	Fusion gene ID: 32319
		Hgene	Tgene
	Gene symbol	RSU1	PARG
	Gene ID	6251	8505
	Gene name	Ras suppressor protein 1	poly(ADP-ribose) glycohydrolase
	Synonyms	RSP-1	PARG99
	Cytomap	10p13	10q11.23
	Type of gene	protein-coding	protein-coding
	Description	ras suppressor protein 1ras suppressor protein 1 variant 1ras suppressor protein 1 variant 2ras suppressor protein 1 variant 3ras suppressor protein 1 variant 5rsu-1	poly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform
	Modification date	20180522	20180523
	UniProtAcc	Q15404	Q86W56
	Ensembl transtripts involved in fusion gene	ENST00000377921, ENST00000345264, ENST00000602389, ENST00000464074,	ENST00000402038, ENST00000492350,
Fusion gene scores	* DoF score	6 X 4 X 6=144	7 X 6 X 4=168
	# samples	6	7
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RSU1 [Title/Abstract] AND PARG [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PARG	GO:1990966	ATP generation from poly-ADP-D-ribose	27257257

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	STAD	TCGA-BR-7716-01A	RSU1	chr10	16794538	-	PARG	chr10	51051678	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000377921	ENST00000402038	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
5CDS-intron	ENST00000377921	ENST00000492350	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
Frame-shift	ENST00000345264	ENST00000402038	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
5CDS-intron	ENST00000345264	ENST00000492350	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
Frame-shift	ENST00000602389	ENST00000402038	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
5CDS-intron	ENST00000602389	ENST00000492350	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
5UTR-3CDS	ENST00000464074	ENST00000402038	RSU1	chr10	16794538	-	PARG	chr10	51051678	-
5UTR-intron	ENST00000464074	ENST00000492350	RSU1	chr10	16794538	-	PARG	chr10	51051678	-

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FusionProtFeatures for RSU1_PARG

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RSU1 Q15404	PARG Q86W56
Potentially plays a role in the Ras signal transductionpathway. Capable of suppressing v-Ras transformation in vitro.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

110_133

199

278

Repeat

Note=LRR 4

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

135_156

199

278

Repeat

Note=LRR 5

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

158_179

199

278

Repeat

Note=LRR 6

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

181_202

199

278

Repeat

Note=LRR 7

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

41_63

199

278

Repeat

Note=LRR 1

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

64_85

199

278

Repeat

Note=LRR 2

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000345264

87_109

199

278

Repeat

Note=LRR 3

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

110_133

199

278

Repeat

Note=LRR 4

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

135_156

199

278

Repeat

Note=LRR 5

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

158_179

199

278

Repeat

Note=LRR 6

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

181_202

199

278

Repeat

Note=LRR 7

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

41_63

199

278

Repeat

Note=LRR 1

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

64_85

199

278

Repeat

Note=LRR 2

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000377921

87_109

199

278

Repeat

Note=LRR 3

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

110_133

146

225

Repeat

Note=LRR 4

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

41_63

146

225

Repeat

Note=LRR 1

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

64_85

146

225

Repeat

Note=LRR 2

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

87_109

146

225

Repeat

Note=LRR 3

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

610_795

299

492

Region

Note=Catalytic

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

726_727

299

492

Region

Note=Substrate binding

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

869_874

299

492

Region

Note=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

135_156

146

225

Repeat

Note=LRR 5

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

158_179

146

225

Repeat

Note=LRR 6

Hgene

RSU1

chr10:16794538

chr10:51051678

ENST00000602389

181_202

146

225

Repeat

Note=LRR 7

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

10_16

299

492

Motif

Nuclear localization signal

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

76_83

299

492

Motif

Note=PIP-box (PCNA interacting peptide)

Tgene

PARG

chr10:16794538

chr10:51051678

ENST00000402038

1_456

299

492

Region

Note=A-domain

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FusionGeneSequence for RSU1_PARG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_392aa
MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKH
LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT
QLKELHIQGNRLTVLPPELGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRP
GVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCST

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_1176nt
ATGTCCAAGTCTCTGAAGAAGTTGGTGGAGGAGAGCCGGGAGAAGAACCAGCCCGAGGTGGACATGAGTGACCGGGGCATCTCCAACATG
CTGGATGTCAACGGCCTCTTTACCTTATCCCATATCACACAACTGGTCCTCAGCCATAACAAGCTAACAATGGTGCCACCGAACATCGCA
GAACTGAAGAATTTGGAGGTGCTCAACTTTTTTAATAACCAAATCGAGGAGCTGCCCACACAGATCAGTAGCCTTCAGAAACTCAAACAC
CTGAACCTTGGCATGAACAGGCTGAACACTTTGCCACGAGGCTTCGGCTCCCTGCCAGCTCTTGAGGTTCTGGACTTGACGTACAACAAC
TTGAGCGAAAATTCTCTTCCTGGAAACTTCTTCTACCTGACCACCCTGCGTGCACTCTATCTAAGTGACAACGATTTTGAAATCCTGCCG
CCAGATATTGGGAAGCTCACAAAGTTGCAGATACTCAGCCTTAGGGATAACGACCTGATCTCGCTGCCTAAGGAAATCGGGGAGCTTACC
CAGCTTAAAGAGCTCCACATTCAGGGGAACCGCCTCACCGTTCTGCCCCCAGAACTAGGTACTGAGCAGTACAGTGAATACACAGGCTAT
GCTGAGACATATCGTTGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGGCAGCGGCGCTGCACTGAGATCGTTGCCATCGAT
GCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAAATGAGACGCGAGCTGAACAAGGCTTACTGTGGATTTCTCCGTCCT
GGAGTTTCTTCAGAGAATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCCAGGTTAAAAGCCTTAATA
CAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTCACCTTTGGGGACTCAGAATTGATGAGAGACATTTACAGCATGCAC
ATTTTCCTTACTGAAAGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGATACTACAATGAAGAATGCAGAAACTGTTCCACC
CCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTCGAGTCCTGTGCAGAGACCGCTGACCATTCAGGGCAAAGGACAGGG

* Fusion transcript sequences (Full-length transcript).

>In-frame_RSU1_ENST00000377921_chr10_16794538_-_PARG_ENST00000402038_chr10_51051678_-_2539nt
GGGCAGCTGGAGTGCGTTCTGCCGAAGCTTGTGGTTGCACGCCCATCGTCTTAGGGGCTACCTTCCGTGGTGAGTGTGTGCGGTGTTGCA
CTTGGGGTTGCTTCTCGCTGCGTGGCCGCAGCGGGGCTGAACCCTTCCCACTCCATCCCCTCCCCGCACCCGGACCAGCCCCTGGGACGC
CCTCGGACGCCCACCCGCTCCAACCCTGGGGAAGCCTCAGAGTGGCAGCGAAGGCCTCTTGCCTTTCCGCCTCTGCGCTTGCTGTCATCG
CCCACGTGCTTTGTTGTTGTTCGGTGCAGACCATGTCCAAGTCTCTGAAGAAGTTGGTGGAGGAGAGCCGGGAGAAGAACCAGCCCGAGG
TGGACATGAGTGACCGGGGCATCTCCAACATGCTGGATGTCAACGGCCTCTTTACCTTATCCCATATCACACAACTGGTCCTCAGCCATA
ACAAGCTAACAATGGTGCCACCGAACATCGCAGAACTGAAGAATTTGGAGGTGCTCAACTTTTTTAATAACCAAATCGAGGAGCTGCCCA
CACAGATCAGTAGCCTTCAGAAACTCAAACACCTGAACCTTGGCATGAACAGGCTGAACACTTTGCCACGAGGCTTCGGCTCCCTGCCAG
CTCTTGAGGTTCTGGACTTGACGTACAACAACTTGAGCGAAAATTCTCTTCCTGGAAACTTCTTCTACCTGACCACCCTGCGTGCACTCT
ATCTAAGTGACAACGATTTTGAAATCCTGCCGCCAGATATTGGGAAGCTCACAAAGTTGCAGATACTCAGCCTTAGGGATAACGACCTGA
TCTCGCTGCCTAAGGAAATCGGGGAGCTTACCCAGCTTAAAGAGCTCCACATTCAGGGGAACCGCCTCACCGTTCTGCCCCCAGAACTAG
GTACTGAGCAGTACAGTGAATACACAGGCTATGCTGAGACATATCGTTGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGGC
AGCGGCGCTGCACTGAGATCGTTGCCATCGATGCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAAATGAGACGCGAGC
TGAACAAGGCTTACTGTGGATTTCTCCGTCCTGGAGTTTCTTCAGAGAATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCT
TTGGGGGTGATGCCAGGTTAAAAGCCTTAATACAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTCACCTTTGGGGACT
CAGAATTGATGAGAGACATTTACAGCATGCACATTTTCCTTACTGAAAGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGAT
ACTACAATGAAGAATGCAGAAACTGTTCCACCCCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTCGAGTCCTGTGCAG
AGACCGCTGACCATTCAGGGCAAAGGACAGGGACCTGAGGAGCCGAGCGAATAGCATCTCCTCCCACCTCCCACCAGAGACGTCCTGTTT
GAGCTGTCAGGTGTAATATATGAATTGACTTAAGTTAATATAAATGTGTACATAATCCACATTTGTAGTCAAGGACGCAATCTCTTCCAC
ACATGTGCAGTTGTCAGTTGGTACATCTAAACTCCCTCCATCCTGACTCACGTGGACTTAGATATGTTTTGTTTCTATTTTCTTCTATTT
CAGTTTTTCATTCTTTGATGTTTATTTCTTTTGTCCATCAGATCTCTTGTGAAATCCCATGGAAGGTTGTGCTCAGCCTGTCGGGTCTCT
TTCTTCCTGCCCATATATTATACCAGTTGCTTCTGCAGCCCGCAGATGCCAGCGATGCCAGGAAACAAGTTGAAATCCAGGAATCTCTTT
AACTGATTTTGCTAAAAATCTCCCTGTGAGCCTTCCACTCAACTCTTAATATGCTTGCATTGTTTAAGTTTTTAAATTCTGAAAATTAAT
AATTAGGGTTTTTTTCATATGTGTTGCATAATGCAAACCTCCTAGGTTAAAATAGTTTCTTTATTTAAGATAGAATAATTTCCAGAAATT
GTACTTTTGAGGTATCATTTTTATCTGTAATGGTTTGTCTGTCTTTTTTCCTCTGATCAGTATTTTTTTATACCAGTTTTGGAGACTGGC
TGAGATGAAAGGAAATGTGGAATAAAAGGAGGTTTTCCTGATGTGGTGTAAAGAAAACAGATTCAAGAGAATTGAAGATTTTTTTTGTTT
CTTGGTACTTTTTTCTTTTTAAATTAGGACTAATGTTTCTTTTGTGGTGCTTGAGGCATATTCATATAACCAAAGTTTGAGAACTGGGAA
CTTCATGCTGATTTGTACATATTGAAGTTTCTCTGGTATTCAAAGGTTATATAGTGAATGAATTTTCATTAATAAATCACTTTGTCAGAA
ACTCCCATATCATCTATATTTTATATATGTATATATAAACGTATGCTCTTTAAGTGTGTCTATATGTGAGCACATAAAATCTAAATAAAA

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FusionGenePPI for RSU1_PARG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
RSU1	ACP6, ILK, HGS, GSK3B, ELAVL1, LRRK1, APP, VCP, FN1, LRCH3, FAM114A1, PARVA, PPAT, SEC24D, SUGT1, LIMS1, PARVB, PARVG, CBS, HNRNPA3, NDUFA8, NTMT1, PFKP, DAZAP1, DHX15, FLNB, HADH, USP3, TIAL1, TKT	PARG	CASP3, KIAA0101, NTRK1, HIST1H2BG, BRCA1, BARD1, ATF6

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for RSU1_PARG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RSU1_PARG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RSU1	C0029456	Osteoporosis	1	CTD_human
Hgene	RSU1	C0263454	Chloracne	1	CTD_human
Tgene	PARG	C0007621	Neoplastic Cell Transformation	2	CTD_human
Tgene	PARG	C0752351	Embryo Loss	1	CTD_human

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Fusion gene ID: 32319

FusionGeneSummary for RSU1_PARG

FusionProtFeatures for RSU1_PARG

FusionGeneSequence for RSU1_PARG

FusionGenePPI for RSU1_PARG

RelatedDrugs for RSU1_PARG

RelatedDiseases for RSU1_PARG