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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32316

FusionGeneSummary for RSU1_BAALC

check button Fusion gene summary
Fusion gene informationFusion gene name: RSU1_BAALC
Fusion gene ID: 32316
HgeneTgene
Gene symbol

RSU1

BAALC

Gene ID

6251

79870

Gene nameRas suppressor protein 1BAALC, MAP3K1 and KLF4 binding
SynonymsRSP-1-
Cytomap

10p13

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionras suppressor protein 1ras suppressor protein 1 variant 1ras suppressor protein 1 variant 2ras suppressor protein 1 variant 3ras suppressor protein 1 variant 5rsu-1brain and acute leukemia cytoplasmic proteinBAALC, MEKK1 and KLF4 bindingbrain and acute leukemia, cytoplasmic
Modification date2018052220180519
UniProtAcc

Q15404

Q8WXS3

Ensembl transtripts involved in fusion geneENST00000377921, ENST00000345264, 
ENST00000602389, ENST00000464074, 
ENST00000309982, ENST00000438105, 
ENST00000297574, ENST00000330955, 
ENST00000306391, ENST00000523754, 
Fusion gene scores* DoF score6 X 4 X 6=1446 X 2 X 5=60
# samples 67
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RSU1 [Title/Abstract] AND BAALC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-LC-A66R-01ARSU1chr10

16858972

-BAALCchr8

104225147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000377921ENST00000309982RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000377921ENST00000438105RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000377921ENST00000297574RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000377921ENST00000330955RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000377921ENST00000306391RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000377921ENST00000523754RSU1chr10

16858972

-BAALCchr8

104225147

+
Frame-shitENST00000345264ENST00000309982RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000345264ENST00000438105RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000345264ENST00000297574RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000345264ENST00000330955RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000345264ENST00000306391RSU1chr10

16858972

-BAALCchr8

104225147

+
5CDS-intronENST00000345264ENST00000523754RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-3CDSENST00000602389ENST00000309982RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000602389ENST00000438105RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000602389ENST00000297574RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000602389ENST00000330955RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000602389ENST00000306391RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000602389ENST00000523754RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-3CDSENST00000464074ENST00000309982RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000464074ENST00000438105RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000464074ENST00000297574RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000464074ENST00000330955RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000464074ENST00000306391RSU1chr10

16858972

-BAALCchr8

104225147

+
intron-intronENST00000464074ENST00000523754RSU1chr10

16858972

-BAALCchr8

104225147

+

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FusionProtFeatures for RSU1_BAALC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RSU1

Q15404

BAALC

Q8WXS3

Potentially plays a role in the Ras signal transductionpathway. Capable of suppressing v-Ras transformation in vitro. May play a synaptic role at the postsynaptic lipid raftspossibly through interaction with CAMK2A.{ECO:0000250|UniProtKB:Q920K5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RSU1_BAALC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RSU1_BAALC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RSU1ACP6, ILK, HGS, GSK3B, ELAVL1, LRRK1, APP, VCP, FN1, LRCH3, FAM114A1, PARVA, PPAT, SEC24D, SUGT1, LIMS1, PARVB, PARVG, CBS, HNRNPA3, NDUFA8, NTMT1, PFKP, DAZAP1, DHX15, FLNB, HADH, USP3, TIAL1, TKTBAALCMDFI, ATXN1, CHEK2, MAP3K1, KLF4, ATP1B3, RNF2, CHD1L, CINP, OSBPL1A, AP1G1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RSU1_BAALC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RSU1_BAALC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRSU1C0029456Osteoporosis1CTD_human
HgeneRSU1C0263454Chloracne1CTD_human
TgeneBAALCC0023467Leukemia, Myelocytic, Acute1CTD_human