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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32284

FusionGeneSummary for RSF1_INTS4

check button Fusion gene summary
Fusion gene informationFusion gene name: RSF1_INTS4
Fusion gene ID: 32284
HgeneTgene
Gene symbol

RSF1

INTS4

Gene ID

51773

92105

Gene nameremodeling and spacing factor 1integrator complex subunit 4
SynonymsHBXAP|RSF-1|XAP8|p325INT4|MST093
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionremodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complexintegrator complex subunit 4MSTP093
Modification date2018052320180523
UniProtAcc

Q96T23

Q96HW7

Ensembl transtripts involved in fusion geneENST00000308488, ENST00000360355, 
ENST00000480887, ENST00000530604, 
ENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 
Fusion gene scores* DoF score15 X 8 X 9=10806 X 4 X 5=120
# samples 177
** MAII scorelog2(17/1080*10)=-2.66742466091313
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RSF1 [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRSF1

GO:0006334

nucleosome assembly

12972596

HgeneRSF1

GO:0006338

chromatin remodeling

9836642

HgeneRSF1

GO:0006352

DNA-templated transcription, initiation

9836642

HgeneRSF1

GO:0016584

nucleosome positioning

9836642

HgeneRSF1

GO:0043392

negative regulation of DNA binding

12972596

HgeneRSF1

GO:0045892

negative regulation of transcription, DNA-templated

11944984

HgeneRSF1

GO:0045893

positive regulation of transcription, DNA-templated

11788598

HgeneRSF1

GO:0050434

positive regulation of viral transcription

11788598

TgeneINTS4

GO:0016180

snRNA processing

16239144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-60-2726-01ARSF1chr11

77531574

-INTS4chr11

77639593

-
TCGARVSKCMTCGA-EB-A57M-01ARSF1chr11

77531574

-INTS4chr11

77594998

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000308488ENST00000534064RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-intronENST00000308488ENST00000535943RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-5UTRENST00000308488ENST00000525931RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-5UTRENST00000308488ENST00000529807RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-intronENST00000308488ENST00000527522RSF1chr11

77531574

-INTS4chr11

77639593

-
Frame-shiftENST00000360355ENST00000534064RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-intronENST00000360355ENST00000535943RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-5UTRENST00000360355ENST00000525931RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-5UTRENST00000360355ENST00000529807RSF1chr11

77531574

-INTS4chr11

77639593

-
5CDS-intronENST00000360355ENST00000527522RSF1chr11

77531574

-INTS4chr11

77639593

-
intron-3CDSENST00000480887ENST00000534064RSF1chr11

77531574

-INTS4chr11

77639593

-
intron-intronENST00000480887ENST00000535943RSF1chr11

77531574

-INTS4chr11

77639593

-
intron-5UTRENST00000480887ENST00000525931RSF1chr11

77531574

-INTS4chr11

77639593

-
intron-5UTRENST00000480887ENST00000529807RSF1chr11

77531574

-INTS4chr11

77639593

-
intron-intronENST00000480887ENST00000527522RSF1chr11

77531574

-INTS4chr11

77639593

-
5UTR-3CDSENST00000530604ENST00000534064RSF1chr11

77531574

-INTS4chr11

77639593

-
5UTR-intronENST00000530604ENST00000535943RSF1chr11

77531574

-INTS4chr11

77639593

-
5UTR-5UTRENST00000530604ENST00000525931RSF1chr11

77531574

-INTS4chr11

77639593

-
5UTR-5UTRENST00000530604ENST00000529807RSF1chr11

77531574

-INTS4chr11

77639593

-
5UTR-intronENST00000530604ENST00000527522RSF1chr11

77531574

-INTS4chr11

77639593

-
In-frameENST00000308488ENST00000534064RSF1chr11

77531574

-INTS4chr11

77594998

-
In-frameENST00000308488ENST00000535943RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000308488ENST00000525931RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000308488ENST00000529807RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000308488ENST00000527522RSF1chr11

77531574

-INTS4chr11

77594998

-
In-frameENST00000360355ENST00000534064RSF1chr11

77531574

-INTS4chr11

77594998

-
In-frameENST00000360355ENST00000535943RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000360355ENST00000525931RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000360355ENST00000529807RSF1chr11

77531574

-INTS4chr11

77594998

-
5CDS-intronENST00000360355ENST00000527522RSF1chr11

77531574

-INTS4chr11

77594998

-
intron-3CDSENST00000480887ENST00000534064RSF1chr11

77531574

-INTS4chr11

77594998

-
intron-3CDSENST00000480887ENST00000535943RSF1chr11

77531574

-INTS4chr11

77594998

-
intron-intronENST00000480887ENST00000525931RSF1chr11

77531574

-INTS4chr11

77594998

-
intron-intronENST00000480887ENST00000529807RSF1chr11

77531574

-INTS4chr11

77594998

-
intron-intronENST00000480887ENST00000527522RSF1chr11

77531574

-INTS4chr11

77594998

-
5UTR-3CDSENST00000530604ENST00000534064RSF1chr11

77531574

-INTS4chr11

77594998

-
5UTR-3CDSENST00000530604ENST00000535943RSF1chr11

77531574

-INTS4chr11

77594998

-
5UTR-intronENST00000530604ENST00000525931RSF1chr11

77531574

-INTS4chr11

77594998

-
5UTR-intronENST00000530604ENST00000529807RSF1chr11

77531574

-INTS4chr11

77594998

-
5UTR-intronENST00000530604ENST00000527522RSF1chr11

77531574

-INTS4chr11

77594998

-

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FusionProtFeatures for RSF1_INTS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RSF1

Q96T23

INTS4

Q96HW7

Required for assembly of regular nucleosome arrays bythe RSF chromatin-remodeling complex (PubMed:12972596).Facilitates transcription of hepatitis B virus (HBV) genes by thepX transcription activator. In case of infection by HBV, togetherwith pX, it represses TNF-alpha induced NF-kappa-B transcriptionactivation. Represses transcription when artificially recruited tochromatin by fusion to a heterogeneous DNA binding domain(PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598,ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}. Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012145_183-8506RepeatNote=HEAT 2
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012190_228-8506RepeatNote=HEAT 3
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012229_263-8506RepeatNote=HEAT 4
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012277_313-8506RepeatNote=HEAT 5
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012369_405-8506RepeatNote=HEAT 6
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012406_444-8506RepeatNote=HEAT 7
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-012446_484-8506RepeatNote=HEAT 8
TgeneINTS4chr11:77531574chr11:77594998ENST00000529807-01266_105-8506RepeatNote=HEAT 1
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69277_313239339RepeatNote=HEAT 5
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69369_405239339RepeatNote=HEAT 6
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69406_444239339RepeatNote=HEAT 7
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69446_484239339RepeatNote=HEAT 8

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-116942_1012621442Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-115942_1012621411Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-111942_1012-3541190Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-1161080_1083621442Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-1161146_1243621442Compositional biasNote=Arg-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-1161286_1292621442Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-1161419_1424621442Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-116226_372621442Compositional biasNote=Glu-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-116875_884621442Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-1151080_1083621411Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-1151146_1243621411Compositional biasNote=Arg-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-1151286_1292621411Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-1151419_1424621411Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-115226_372621411Compositional biasNote=Glu-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-115875_884621411Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-1111080_1083-3541190Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-1111146_1243-3541190Compositional biasNote=Arg-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-1111286_1292-3541190Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-1111419_1424-3541190Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-111226_372-3541190Compositional biasNote=Glu-rich
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-111875_884-3541190Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-11617_84621442DomainNote=DDT
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-11517_84621411DomainNote=DDT
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-11117_84-3541190DomainNote=DDT
HgeneRSF1chr11:77531574chr11:77594998ENST00000308488-116891_941621442Zinc fingerPHD-type
HgeneRSF1chr11:77531574chr11:77594998ENST00000360355-115891_941621411Zinc fingerPHD-type
HgeneRSF1chr11:77531574chr11:77594998ENST00000480887-111891_941-3541190Zinc fingerPHD-type
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023145_183864964RepeatNote=HEAT 2
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023190_228864964RepeatNote=HEAT 3
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023229_263864964RepeatNote=HEAT 4
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023277_313864964RepeatNote=HEAT 5
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023369_405864964RepeatNote=HEAT 6
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023406_444864964RepeatNote=HEAT 7
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-2023446_484864964RepeatNote=HEAT 8
TgeneINTS4chr11:77531574chr11:77594998ENST00000534064-202366_105864964RepeatNote=HEAT 1
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69145_183239339RepeatNote=HEAT 2
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69190_228239339RepeatNote=HEAT 3
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-69229_263239339RepeatNote=HEAT 4
TgeneINTS4chr11:77531574chr11:77594998ENST00000535943-6966_105239339RepeatNote=HEAT 1


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FusionGeneSequence for RSF1_INTS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RSF1_INTS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RSF1NFKB1, SMARCA5, CENPA, SIRT7, SP1, COPS6, CSNK2A1, HIST1H2BG, HIST1H3A, EWSR1, MARK2, ATXN3, KAT6A, MCM2INTS4RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, INTS9, HECW2, HGS, ZMIZ2, USHBP1, HLA-B, SLAMF1, VSIG4, LOC554223, ISLR, INTS4P2, TGOLN2, FAF2, C7orf26, CPSF3L, FAM98A, ASUN, NTRK1, PPP2CA, PPP2CB, PPP2R1A, VWA9, SIGLECL1, BMP2K, VSIG1, PMEL, PDCD1, CD70, GORASP1, AP2A1, CD79B, SIGLEC5, ADAM32, PCDHA12, AP2A2, CLEC2D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RSF1_INTS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RSF1_INTS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneINTS4C0033578Prostatic Neoplasms1CTD_human