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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32267

FusionGeneSummary for RRP1_RRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RRP1_RRP1
Fusion gene ID: 32267
HgeneTgene
Gene symbol

RRP1

RRP1

Gene ID

23076

23076

Gene nameribosomal RNA processing 1Bribosomal RNA processing 1B
SynonymsKIAA0179|NNP1L|Nnp1|PPP1R136|RRP1KIAA0179|NNP1L|Nnp1|PPP1R136|RRP1
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionribosomal RNA processing protein 1 homolog BRRP1-like protein Bprotein phosphatase 1, regulatory subunit 136ribosomal RNA processing 1 homolog Bribosomal RNA processing protein 1 homolog BRRP1-like protein Bprotein phosphatase 1, regulatory subunit 136ribosomal RNA processing 1 homolog B
Modification date2018052320180523
UniProtAcc

P56182

P56182

Ensembl transtripts involved in fusion geneENST00000497547, ENST00000471909, 
ENST00000497547, ENST00000471909, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 3 X 5=75
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRP1 [Title/Abstract] AND RRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRRP1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneRRP1

GO:0098586

cellular response to virus

26311876

TgeneRRP1

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneRRP1

GO:0098586

cellular response to virus

26311876


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA421801RRP1chr21

45222525

+RRP1chr21

45213293

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000497547ENST00000497547RRP1chr21

45222525

+RRP1chr21

45213293

+
intron-intronENST00000497547ENST00000471909RRP1chr21

45222525

+RRP1chr21

45213293

+
intron-intronENST00000471909ENST00000497547RRP1chr21

45222525

+RRP1chr21

45213293

+
intron-intronENST00000471909ENST00000471909RRP1chr21

45222525

+RRP1chr21

45213293

+

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FusionProtFeatures for RRP1_RRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRP1

P56182

RRP1

P56182

Plays a critical role in the generation of 28S rRNA. Plays a critical role in the generation of 28S rRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRP1_RRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRP1_RRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRP1_RRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RRP1_RRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource