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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32261

FusionGeneSummary for RRP12_RRP12

check button Fusion gene summary
Fusion gene informationFusion gene name: RRP12_RRP12
Fusion gene ID: 32261
HgeneTgene
Gene symbol

RRP12

RRP12

Gene ID

23223

23223

Gene nameribosomal RNA processing 12 homologribosomal RNA processing 12 homolog
SynonymsKIAA0690KIAA0690
Cytomap

10q24.1

10q24.1

Type of geneprotein-codingprotein-coding
DescriptionRRP12-like proteinRRP12-like protein
Modification date2018051920180519
UniProtAcc

Q5JTH9

Q5JTH9

Ensembl transtripts involved in fusion geneENST00000479481, ENST00000370992, 
ENST00000536831, ENST00000315563, 
ENST00000414986, 
ENST00000479481, 
ENST00000370992, ENST00000536831, 
ENST00000315563, ENST00000414986, 
Fusion gene scores* DoF score6 X 6 X 3=1084 X 5 X 4=80
# samples 65
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRP12 [Title/Abstract] AND RRP12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM904976RRP12chr10

99134715

-RRP12chr10

99135413

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000479481ENST00000479481RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000479481ENST00000370992RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000479481ENST00000536831RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000479481ENST00000315563RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000479481ENST00000414986RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000370992ENST00000479481RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000370992ENST00000370992RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000370992ENST00000536831RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000370992ENST00000315563RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000370992ENST00000414986RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000536831ENST00000479481RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000536831ENST00000370992RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000536831ENST00000536831RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000536831ENST00000315563RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000536831ENST00000414986RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000315563ENST00000479481RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000315563ENST00000370992RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000315563ENST00000536831RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000315563ENST00000315563RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000315563ENST00000414986RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000414986ENST00000479481RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000414986ENST00000370992RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000414986ENST00000536831RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000414986ENST00000315563RRP12chr10

99134715

-RRP12chr10

99135413

-
intron-intronENST00000414986ENST00000414986RRP12chr10

99134715

-RRP12chr10

99135413

-

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FusionProtFeatures for RRP12_RRP12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRP12

Q5JTH9

RRP12

Q5JTH9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRP12_RRP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRP12_RRP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRP12_RRP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RRP12_RRP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource