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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32252

FusionGeneSummary for RRM2_RREB1

check button Fusion gene summary
Fusion gene informationFusion gene name: RRM2_RREB1
Fusion gene ID: 32252
HgeneTgene
Gene symbol

RRM2

RREB1

Gene ID

6241

6239

Gene nameribonucleotide reductase regulatory subunit M2ras responsive element binding protein 1
SynonymsR2|RR2|RR2MFINB|HNT|LZ321|RREB-1|Zep-1
Cytomap

2p25.1

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionribonucleoside-diphosphate reductase subunit M2ribonucleotide reductase M2 polypeptideribonucleotide reductase small chainribonucleotide reductase small subunitras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1
Modification date2018052320180523
UniProtAcc

P31350

Q92766

Ensembl transtripts involved in fusion geneENST00000360566, ENST00000304567, 
ENST00000379933, ENST00000379938, 
ENST00000334984, ENST00000349384, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 4=252
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRM2 [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FX-01ARRM2chr2

10269281

+RREB1chr6

7176888

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360566ENST00000379933RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000360566ENST00000379938RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000360566ENST00000334984RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000360566ENST00000349384RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000304567ENST00000379933RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000304567ENST00000379938RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000304567ENST00000334984RRM2chr2

10269281

+RREB1chr6

7176888

+
5CDS-5UTRENST00000304567ENST00000349384RRM2chr2

10269281

+RREB1chr6

7176888

+

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FusionProtFeatures for RRM2_RREB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRM2

P31350

RREB1

Q92766

Provides the precursors necessary for DNA synthesis.Catalyzes the biosynthesis of deoxyribonucleotides from thecorresponding ribonucleotides. Inhibits Wnt signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRM2_RREB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRM2_RREB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RRM2RRM1, TP53, KAT5, ELAVL1, CCNF, NR1H4, SKP2, PCMT1, NONO, RBMX, DNM1L, RRM2B, INPPL1, FZR1, CDC27, ANAPC4, FAF2, CSTF1, NPLOC4, ASNS, DDX19B, DNAAF5, MAPK1, PLK1, PPP2R5D, NTRK1, OFD1, PCM1, MKS1, CEP170, SCLT1, POC1A, STIL, ANAPC15, SDHAF2, TMEM248, CDK9, ARID2, PRKDC, PARP1, CDKN2A, PIK3CA, WEE1, VHL, PDGFRA, ERBB2, RPS6KB1, SPAG9, TRIM25, HSPA4, HSP90AA1RREB1KDM1A, CTBP1, AR, HIST3H3, HDAC2, HDAC3, HDAC1, BLM, SNCA, SPATA20, ARL6, NEK7, TOR1AIP2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRM2_RREB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRRM2P31350DB00242CladribineRibonucleoside-diphosphate reductase subunit M2small moleculeapproved|investigational

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RelatedDiseases for RRM2_RREB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRRM2C0009404Colorectal Neoplasms1CTD_human
HgeneRRM2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneRRM2C2239176Liver carcinoma1CTD_human