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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32251

FusionGeneSummary for RRM2_NCKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RRM2_NCKAP1
Fusion gene ID: 32251
HgeneTgene
Gene symbol

RRM2

NCKAP1

Gene ID

6241

10787

Gene nameribonucleotide reductase regulatory subunit M2NCK associated protein 1
SynonymsR2|RR2|RR2MHEM2|NAP1|NAP125|p125Nap1
Cytomap

2p25.1

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionribonucleoside-diphosphate reductase subunit M2ribonucleotide reductase M2 polypeptideribonucleotide reductase small chainribonucleotide reductase small subunitnck-associated protein 1membrane-associated protein HEM-2
Modification date2018052320180523
UniProtAcc

P31350

Q9Y2A7

Ensembl transtripts involved in fusion geneENST00000360566, ENST00000304567, 
ENST00000361354, ENST00000360982, 
ENST00000478449, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 7 X 5=280
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRM2 [Title/Abstract] AND NCKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCKAP1

GO:0016601

Rac protein signal transduction

21107423

TgeneNCKAP1

GO:2000601

positive regulation of Arp2/3 complex-mediated actin nucleation

21107423


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA826373RRM2chr2

10271152

-NCKAP1chr2

183866687

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000360566ENST00000361354RRM2chr2

10271152

-NCKAP1chr2

183866687

+
3UTR-3CDSENST00000360566ENST00000360982RRM2chr2

10271152

-NCKAP1chr2

183866687

+
3UTR-intronENST00000360566ENST00000478449RRM2chr2

10271152

-NCKAP1chr2

183866687

+
3UTR-3CDSENST00000304567ENST00000361354RRM2chr2

10271152

-NCKAP1chr2

183866687

+
3UTR-3CDSENST00000304567ENST00000360982RRM2chr2

10271152

-NCKAP1chr2

183866687

+
3UTR-intronENST00000304567ENST00000478449RRM2chr2

10271152

-NCKAP1chr2

183866687

+

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FusionProtFeatures for RRM2_NCKAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRM2

P31350

NCKAP1

Q9Y2A7

Provides the precursors necessary for DNA synthesis.Catalyzes the biosynthesis of deoxyribonucleotides from thecorresponding ribonucleotides. Inhibits Wnt signaling. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex. Actinremodeling activity is regulated by RAC1. As component of theWAVE1 complex, required for BDNF-NTRK2 endocytic trafficking andsignaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRM2_NCKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRM2_NCKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRM2_NCKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRRM2P31350DB00242CladribineRibonucleoside-diphosphate reductase subunit M2small moleculeapproved|investigational

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RelatedDiseases for RRM2_NCKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRRM2C0009404Colorectal Neoplasms1CTD_human
HgeneRRM2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneRRM2C2239176Liver carcinoma1CTD_human