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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32249

FusionGeneSummary for RRM2B_ZFPM2

check button Fusion gene summary
Fusion gene informationFusion gene name: RRM2B_ZFPM2
Fusion gene ID: 32249
HgeneTgene
Gene symbol

RRM2B

ZFPM2

Gene ID

50484

23414

Gene nameribonucleotide reductase regulatory TP53 inducible subunit M2Bzinc finger protein, FOG family member 2
SynonymsMTDPS8A|MTDPS8B|P53R2DIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2
Cytomap

8q22.3

8q23.1

Type of geneprotein-codingprotein-coding
Descriptionribonucleoside-diphosphate reductase subunit M2 BTP53-inducible ribonucleotide reductase M2 Bp53-inducible ribonucleotide reductase small subunit 2 homologp53-inducible ribonucleotide reductase small subunit 2 short form betap53-inducible ribonucleotizinc finger protein ZFPM2FOG-2Friend of GATA2friend of GATA 2friend of GATA protein 2transcription factor GATA4, modulator ofzinc finger protein 89Bzinc finger protein, multitype 2
Modification date2018052320180523
UniProtAcc

Q7LG56

Q8WW38

Ensembl transtripts involved in fusion geneENST00000251810, ENST00000395912, 
ENST00000519317, ENST00000519962, 
ENST00000407775, ENST00000520492, 
ENST00000517361, ENST00000522296, 
ENST00000378472, 
Fusion gene scores* DoF score2 X 1 X 2=48 X 5 X 5=200
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/200*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRM2B [Title/Abstract] AND ZFPM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZFPM2

GO:0045892

negative regulation of transcription, DNA-templated

20206639

TgeneZFPM2

GO:0045944

positive regulation of transcription by RNA polymerase II

10438528


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-GI-A2C8-01ARRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000251810ENST00000407775RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-5UTRENST00000251810ENST00000520492RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000251810ENST00000517361RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000251810ENST00000522296RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000251810ENST00000378472RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
Frame-shiftENST00000395912ENST00000407775RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-5UTRENST00000395912ENST00000520492RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000395912ENST00000517361RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000395912ENST00000522296RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
5CDS-intronENST00000395912ENST00000378472RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-3CDSENST00000519317ENST00000407775RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-5UTRENST00000519317ENST00000520492RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519317ENST00000517361RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519317ENST00000522296RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519317ENST00000378472RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-3CDSENST00000519962ENST00000407775RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-5UTRENST00000519962ENST00000520492RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519962ENST00000517361RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519962ENST00000522296RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+
intron-intronENST00000519962ENST00000378472RRM2Bchr8

103231042

-ZFPM2chr8

106431372

+

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FusionProtFeatures for RRM2B_ZFPM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRM2B

Q7LG56

ZFPM2

Q8WW38

Transcription regulator that plays a central role inheart morphogenesis and development of coronary vessels fromepicardium, by regulating genes that are essential duringcardiogenesis. Essential cofactor that acts via the formation of aheterodimer with transcription factors of the GATA family GATA4,GATA5 and GATA6. Such heterodimer can both activate or represstranscriptional activity, depending on the cell and promotercontext. Also required in gonadal differentiation, possibly beregulating expression of SRY. Probably acts a corepressor of NR2F2(By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRM2B_ZFPM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRM2B_ZFPM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RRM2BRRM1, TP53, MDM2, ATM, AICDA, ORC4, RRM2B, RRM2, INPPL1, TMOD2, SRPK2, MCM2, ZNF131, FZR1, TPM2, SPAG9ZFPM2GATA1, GATA4, CTBP2, MTA1, MTA2, HDAC1, HDAC2, RBBP7, RBBP4, MTA3, ITSN1, UBQLN4, STAT3, IL32, DUSP23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRM2B_ZFPM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRRM2BQ7LG56DB00242CladribineRibonucleoside-diphosphate reductase subunit M2 Bsmall moleculeapproved|investigational

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RelatedDiseases for RRM2B_ZFPM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRRM2BC2749861MITOCHONDRIAL DNA DEPLETION SYNDROME 8A (ENCEPHALOMYOPATHIC TYPE WITH RENAL TUBULOPATHY)3ORPHANET;UNIPROT
HgeneRRM2BC0162670Mitochondrial Myopathies2CTD_human
HgeneRRM2BC0001125Acidosis, Lactic1CTD_human;HPO
HgeneRRM2BC0022658Kidney Diseases1CTD_human
HgeneRRM2BC0026827Muscle hypotonia1CTD_human;HPO
HgeneRRM2BC0872218MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME1CTD_human;ORPHANET
TgeneZFPM2C0039685Tetralogy of Fallot2CTD_human;HPO;ORPHANET;UNIPROT
TgeneZFPM2C401512946,XY SEX REVERSAL 92UNIPROT
TgeneZFPM2C0019284Diaphragmatic Hernia1CTD_human
TgeneZFPM2C1857586CONOTRUNCAL HEART MALFORMATIONS (disorder)1UNIPROT