	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 3224

FusionGeneSummary for ATL2_MAP4K4

Fusion gene summary

Fusion gene information	Fusion gene name: ATL2_MAP4K4
	Fusion gene ID: 3224
		Hgene	Tgene
	Gene symbol	ATL2	MAP4K4
	Gene ID	64225	9448
	Gene name	atlastin GTPase 2	mitogen-activated protein kinase kinase kinase kinase 4
	Synonyms	ARL3IP2\|ARL6IP2\|aip-2\|atlastin2	FLH21957\|HEL-S-31\|HGK\|MEKKK4\|NIK
	Cytomap	2p22.2-p22.1	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	atlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2	mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-
	Modification date	20180519	20180523
	UniProtAcc	Q8NHH9	O95819
	Ensembl transtripts involved in fusion gene	ENST00000378954, ENST00000406122, ENST00000402054, ENST00000539122, ENST00000332337, ENST00000419554, ENST00000452935, ENST00000546051, ENST00000486927,	ENST00000425019, ENST00000324219, ENST00000350198, ENST00000302217, ENST00000413150, ENST00000347699, ENST00000456652, ENST00000350878, ENST00000498066,
Fusion gene scores	* DoF score	5 X 5 X 3=75	10 X 9 X 6=540
	# samples	6	10
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATL2 [Title/Abstract] AND MAP4K4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATL2	GO:0051260	protein homooligomerization	18270207
Tgene	MAP4K4	GO:0006468	protein phosphorylation	9890973
Tgene	MAP4K4	GO:0035556	intracellular signal transduction	9890973
Tgene	MAP4K4	GO:0046328	regulation of JNK cascade	14966141

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCEC	TCGA-A5-A2K2-01A	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000378954	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000378954	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5CDS-intron	ENST00000378954	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000406122	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-intron	ENST00000406122	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000402054	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-intron	ENST00000402054	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-3CDS	ENST00000539122	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5UTR-intron	ENST00000539122	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000332337	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-intron	ENST00000332337	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
Frame-shift	ENST00000419554	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
5CDS-intron	ENST00000419554	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000452935	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-intron	ENST00000452935	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000546051	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-intron	ENST00000546051	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000425019	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000324219	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000350198	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000302217	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000413150	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000347699	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000456652	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-3CDS	ENST00000486927	ENST00000350878	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+
intron-intron	ENST00000486927	ENST00000498066	ATL2	chr2	38604285	-	MAP4K4	chr2	102483674	+

Top

FusionProtFeatures for ATL2_MAP4K4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATL2 Q8NHH9	MAP4K4 O95819
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmicreticulum membranes. Functions in endoplasmic reticulum tubularnetwork biogenesis (PubMed:18270207, PubMed:19665976,PubMed:27619977). {ECO:0000269\|PubMed:18270207,ECO:0000269\|PubMed:19665976, ECO:0000269\|PubMed:27619977}.	Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269\|PubMed:21690388,ECO:0000269\|PubMed:9890973}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for ATL2_MAP4K4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ATL2_MAP4K4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ATL2	ARL6, LPAR6, P2RY8, NTRK1, ADD1, CSNK1G2, SMARCA4, NELFA, BCL7B, RPP38, SNRNP27, FAM120A, NNT, KLHDC2, ATL3, STK39, DENND1A, ACRBP, LSM11, LAMA1, COPG1, SLC2A12, MAS1, C5AR2, IL1R2, CHRM3, SLC22A6, CNGA3, SLC15A1, CD79B, FPR2, DPEP1, HCCS	MAP4K4	BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for ATL2_MAP4K4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for ATL2_MAP4K4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 3224

FusionGeneSummary for ATL2_MAP4K4

FusionProtFeatures for ATL2_MAP4K4

FusionGeneSequence for ATL2_MAP4K4

FusionGenePPI for ATL2_MAP4K4

RelatedDrugs for ATL2_MAP4K4

RelatedDiseases for ATL2_MAP4K4