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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3222

FusionGeneSummary for ATL2_CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATL2_CSN2
Fusion gene ID: 3222
HgeneTgene
Gene symbol

ATL2

CSN2

Gene ID

64225

9318

Gene nameatlastin GTPase 2COP9 signalosome subunit 2
SynonymsARL3IP2|ARL6IP2|aip-2|atlastin2ALIEN|CSN2|SGN2|TRIP15
Cytomap

2p22.2-p22.1

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionatlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15
Modification date2018051920180523
UniProtAcc

Q8NHH9

P05814

Ensembl transtripts involved in fusion geneENST00000378954, ENST00000406122, 
ENST00000402054, ENST00000539122, 
ENST00000332337, ENST00000419554, 
ENST00000452935, ENST00000546051, 
ENST00000486927, 
ENST00000353151, 
Fusion gene scores* DoF score5 X 5 X 3=7514 X 11 X 2=308
# samples 63
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/308*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATL2 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATL2

GO:0051260

protein homooligomerization

18270207

TgeneCSN2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A1KO-01AATL2chr2

38522022

-CSN2chr4

70823352

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000378954ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000406122ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000402054ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000539122ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000332337ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000419554ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000452935ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000546051ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-
intron-3CDSENST00000486927ENST00000353151ATL2chr2

38522022

-CSN2chr4

70823352

-

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FusionProtFeatures for ATL2_CSN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATL2

Q8NHH9

CSN2

P05814

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmicreticulum membranes. Functions in endoplasmic reticulum tubularnetwork biogenesis (PubMed:18270207, PubMed:19665976,PubMed:27619977). {ECO:0000269|PubMed:18270207,ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}. Important role in determination of the surfaceproperties of the casein micelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATL2_CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATL2_CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATL2ARL6, LPAR6, P2RY8, NTRK1, ADD1, CSNK1G2, SMARCA4, NELFA, BCL7B, RPP38, SNRNP27, FAM120A, NNT, KLHDC2, ATL3, STK39, DENND1A, ACRBP, LSM11, LAMA1, COPG1, SLC2A12, MAS1, C5AR2, IL1R2, CHRM3, SLC22A6, CNGA3, SLC15A1, CD79B, FPR2, DPEP1, HCCSCSN2CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATL2_CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATL2_CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSN2C0024667Animal Mammary Neoplasms2CTD_human
TgeneCSN2C0024668Mammary Neoplasms, Experimental2CTD_human