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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32182

FusionGeneSummary for RPS6_RPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6_RPS6
Fusion gene ID: 32182
HgeneTgene
Gene symbol

RPS6

RPS6

Gene ID

6194

6194

Gene nameribosomal protein S6ribosomal protein S6
SynonymsS6S6
Cytomap

9p22.1

9p22.1

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS640S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
Modification date2018052220180522
UniProtAcc

P62753

P62753

Ensembl transtripts involved in fusion geneENST00000380394, ENST00000498815, 
ENST00000380384, ENST00000315377, 
ENST00000380381, 		ENST00000380394, 
ENST00000498815, ENST00000380384, 
ENST00000315377, ENST00000380381, 
Fusion gene scores* DoF score14 X 14 X 2=3923 X 4 X 1=12
# samples 185
** MAII scorelog2(18/392*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS6 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6

GO:0031929

TOR signaling

16428328

HgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888

TgeneRPS6

GO:0031929

TOR signaling

16428328

TgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB216724RPS6chr9

19378488

+RPS6chr9

19378437

-
ChiTaRS3.1AW970974RPS6chr9

19376905

-RPS6chr9

19376844

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380394ENST00000380394RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380394ENST00000498815RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380394ENST00000380384RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380394ENST00000315377RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380394ENST00000380381RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-3CDSENST00000498815ENST00000380394RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000498815ENST00000498815RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000498815ENST00000380384RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000498815ENST00000315377RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000498815ENST00000380381RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-3CDSENST00000380384ENST00000380394RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380384ENST00000498815RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380384ENST00000380384RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380384ENST00000315377RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380384ENST00000380381RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-3CDSENST00000315377ENST00000380394RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000315377ENST00000498815RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000315377ENST00000380384RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000315377ENST00000315377RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000315377ENST00000380381RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-3CDSENST00000380381ENST00000380394RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380381ENST00000498815RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380381ENST00000380384RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380381ENST00000315377RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380381ENST00000380381RPS6chr9

19378488

+RPS6chr9

19378437

-
intron-intronENST00000380394ENST00000380394RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380394ENST00000498815RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380394ENST00000380384RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380394ENST00000315377RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380394ENST00000380381RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000498815ENST00000380394RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000498815ENST00000498815RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000498815ENST00000380384RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000498815ENST00000315377RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000498815ENST00000380381RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380384ENST00000380394RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380384ENST00000498815RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380384ENST00000380384RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380384ENST00000315377RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380384ENST00000380381RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000315377ENST00000380394RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000315377ENST00000498815RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000315377ENST00000380384RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000315377ENST00000315377RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000315377ENST00000380381RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380381ENST00000380394RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380381ENST00000498815RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380381ENST00000380384RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380381ENST00000315377RPS6chr9

19376905

-RPS6chr9

19376844

+
intron-intronENST00000380381ENST00000380381RPS6chr9

19376905

-RPS6chr9

19376844

+

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FusionProtFeatures for RPS6_RPS6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6

P62753

RPS6

P62753

May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA. May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS6_RPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS6_RPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS6_RPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS6P62753DB11638Artenimol40S ribosomal protein S6small moleculeapproved|investigational
TgeneRPS6P62753DB11638Artenimol40S ribosomal protein S6small moleculeapproved|investigational

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RelatedDiseases for RPS6_RPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS6C0038356Stomach Neoplasms1CTD_human
HgeneRPS6C1458155Mammary Neoplasms1CTD_human
HgeneRPS6C2239176Liver carcinoma1CTD_human
TgeneRPS6C0038356Stomach Neoplasms1CTD_human
TgeneRPS6C1458155Mammary Neoplasms1CTD_human
TgeneRPS6C2239176Liver carcinoma1CTD_human