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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32181

FusionGeneSummary for RPS6_RPL27

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6_RPL27
Fusion gene ID: 32181
HgeneTgene
Gene symbol

RPS6

RPL27

Gene ID

6194

6155

Gene nameribosomal protein S6ribosomal protein L27
SynonymsS6DBA16|L27
Cytomap

9p22.1

17q21.31

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS660S ribosomal protein L27large ribosomal subunit protein eL27
Modification date2018052220180523
UniProtAcc

P62753

P61353

Ensembl transtripts involved in fusion geneENST00000380394, ENST00000498815, 
ENST00000380384, ENST00000315377, 
ENST00000380381, 
ENST00000589037, 
ENST00000253788, ENST00000589913, 
ENST00000590864, 
Fusion gene scores* DoF score14 X 14 X 2=3924 X 5 X 2=40
# samples 185
** MAII scorelog2(18/392*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS6 [Title/Abstract] AND RPL27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6

GO:0031929

TOR signaling

16428328

HgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T59674RPS6chr9

19376507

+RPL27chr17

41150472

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380394ENST00000589037RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-5UTRENST00000380394ENST00000253788RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380394ENST00000589913RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380394ENST00000590864RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000498815ENST00000589037RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-5UTRENST00000498815ENST00000253788RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000498815ENST00000589913RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000498815ENST00000590864RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380384ENST00000589037RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-5UTRENST00000380384ENST00000253788RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380384ENST00000589913RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380384ENST00000590864RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000315377ENST00000589037RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-5UTRENST00000315377ENST00000253788RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000315377ENST00000589913RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000315377ENST00000590864RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380381ENST00000589037RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-5UTRENST00000380381ENST00000253788RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380381ENST00000589913RPS6chr9

19376507

+RPL27chr17

41150472

+
intron-intronENST00000380381ENST00000590864RPS6chr9

19376507

+RPL27chr17

41150472

+

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FusionProtFeatures for RPS6_RPL27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6

P62753

RPL27

P61353

May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA. Component of the large ribosomal subunit(PubMed:12962325, PubMed:23636399, PubMed:25957688,PubMed:25901680). Required for proper rRNA processing andmaturation of 28S and 5.8S rRNAs (PubMed:25424902).{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902,ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688,ECO:0000305|PubMed:12962325}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS6_RPL27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS6_RPL27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS6_RPL27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS6P62753DB11638Artenimol40S ribosomal protein S6small moleculeapproved|investigational

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RelatedDiseases for RPS6_RPL27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS6C0038356Stomach Neoplasms1CTD_human
HgeneRPS6C1458155Mammary Neoplasms1CTD_human
HgeneRPS6C2239176Liver carcinoma1CTD_human