FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32180

FusionGeneSummary for RPS6_POSTN

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6_POSTN
Fusion gene ID: 32180
HgeneTgene
Gene symbol

RPS6

POSTN

Gene ID

6194

10631

Gene nameribosomal protein S6periostin
SynonymsS6OSF-2|OSF2|PDLPOSTN|PN
Cytomap

9p22.1

13q13.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6periostinosteoblast specific factor 2 (fasciclin I-like)periodontal ligament-specific periostinperiostin, osteoblast specific factor
Modification date2018052220180523
UniProtAcc

P62753

Q15063

Ensembl transtripts involved in fusion geneENST00000380394, ENST00000498815, 
ENST00000380384, ENST00000315377, 
ENST00000380381, 
ENST00000541179, 
ENST00000379749, ENST00000379747, 
ENST00000379743, ENST00000379742, 
ENST00000541481, ENST00000497145, 
Fusion gene scores* DoF score14 X 14 X 2=3927 X 7 X 3=147
# samples 189
** MAII scorelog2(18/392*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6 [Title/Abstract] AND POSTN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6

GO:0031929

TOR signaling

16428328

HgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888

TgenePOSTN

GO:0007155

cell adhesion

12235007

TgenePOSTN

GO:0071307

cellular response to vitamin K

18450759


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA026363RPS6chr9

19376587

+POSTNchr13

38137332

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000380394ENST00000541179RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380394ENST00000379749RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380394ENST00000379747RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380394ENST00000379743RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380394ENST00000379742RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380394ENST00000541481RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380394ENST00000497145RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000498815ENST00000541179RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000498815ENST00000379749RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000498815ENST00000379747RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000498815ENST00000379743RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000498815ENST00000379742RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000498815ENST00000541481RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000498815ENST00000497145RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380384ENST00000541179RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380384ENST00000379749RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380384ENST00000379747RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380384ENST00000379743RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380384ENST00000379742RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380384ENST00000541481RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380384ENST00000497145RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000315377ENST00000541179RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000315377ENST00000379749RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000315377ENST00000379747RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000315377ENST00000379743RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000315377ENST00000379742RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000315377ENST00000541481RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000315377ENST00000497145RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380381ENST00000541179RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380381ENST00000379749RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380381ENST00000379747RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380381ENST00000379743RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-3UTRENST00000380381ENST00000379742RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380381ENST00000541481RPS6chr9

19376587

+POSTNchr13

38137332

+
intron-intronENST00000380381ENST00000497145RPS6chr9

19376587

+POSTNchr13

38137332

+

Top

FusionProtFeatures for RPS6_POSTN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6

P62753

POSTN

Q15063

May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPS6_POSTN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPS6_POSTN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPS6EIF3B, HSP90AA1, TERF2, POT1, DCC, STAU1, MTOR, RICTOR, MAPKAP1, RPTOR, PCK1, RAD21, NDRG1, ARRB2, SIRT7, HDAC6, TDRD3, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, RPS6KB1, RPS4X, RPL23, RPL5, RPL7, RPS3A, RPSA, RPLP0, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL27A, RPL31, RPL37A, RPL4, RPL6, RPL8, RPS12, RPS14, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS24, RPS25, RPS28, RPS3, RPS5, RPS7, RPS8, RPS2, RPS13, RPL7A, RPL3, RPL30, RPL23A, RPS26, RPS11, RPL9, RPLP1, RPLP2, RPL22, RPS9, EEF2, RPS15, RPL36, RPS17, RPL38, HSP90AB1, RPL32, RPS21, RPL17, RPS27A, RPL29, EEF1A1, FAU, NOP56, FBL, MYBBP1A, NCL, NPM1, HNRNPU, GNL3, NAP1L1, SLC25A5, ILF3, EBNA1BP2, ILF2, HNRNPA1, DHX9, NHP2L1, HNRNPM, NOP58, TUFM, NOLC1, EIF6, RPS27L, RPL10L, RPLP0P6, NOP2, NFIA, HIST1H2AD, VASN, CLINT1, NIFK, HNRNPA0, RRS1, IMPDH2, UPF1, ESR1, MAGOH, EIF4A3, SMURF1, FN1, VCAM1, UBL4A, ITGA4, VHL, PAN2, CD81, IGSF8, ICAM1, PRKACB, PLA2G12A, ATF4, PRKCSH, UPF2, FBXO6, TARDBP, PARK2, GNB2L1, PTOV1, EIF3CL, PNO1, RPS10, RPS18, RPS27, RPS29, SERBP1, SND1, WDR26, WIBG, TSR1, CEP250, TP53, TUBG1, TUBGCP3, VCP, UIMC1, MDM2, CUL7, OBSL1, EIF2A, EIF5, RPS6KB2, NTRK1, EIF5B, RPL10, RPL35, RPL3L, DDX18, PABPC1, RPL13A, RPL26, RPL26L1, RPL27, RPL28, RPL34, RPL35A, LOC101929876, SFN, FRS2, PTEN, XPO1, KIF11, CBX8, NOP9, GAN, CRY2, RC3H1, ZNF746, CNBP, KIAA0020, H2AFX, ZC3HAV1, RPF1, CYLD, TRIM25, BRCA1, LMNA, YAP1, MTF1, USP10, G3BP1, G3BP2, CAPRIN1POSTNILK, MTMR14, MKS1, B9D1, TMEM231


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPS6_POSTN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS6P62753DB11638Artenimol40S ribosomal protein S6small moleculeapproved|investigational

Top

RelatedDiseases for RPS6_POSTN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS6C0038356Stomach Neoplasms1CTD_human
HgeneRPS6C1458155Mammary Neoplasms1CTD_human
HgeneRPS6C2239176Liver carcinoma1CTD_human
TgenePOSTNC0006287Bronchopulmonary Dysplasia1CTD_human
TgenePOSTNC0009404Colorectal Neoplasms1CTD_human
TgenePOSTNC0013182Drug Allergy1CTD_human
TgenePOSTNC0013264Muscular Dystrophy, Duchenne1CTD_human
TgenePOSTNC1319853Asthma, Aspirin-Induced1CTD_human