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Fusion gene ID: 32176 |
FusionGeneSummary for RPS6_NARS2 |
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Fusion gene information | Fusion gene name: RPS6_NARS2 | Fusion gene ID: 32176 | Hgene | Tgene | Gene symbol | RPS6 | NARS2 | Gene ID | 6194 | 79731 |
Gene name | ribosomal protein S6 | asparaginyl-tRNA synthetase 2, mitochondrial | |
Synonyms | S6 | DFNB94|SLM5|asnRS | |
Cytomap | 9p22.1 | 11q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6 | probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P62753 | Q96I59 | |
Ensembl transtripts involved in fusion gene | ENST00000380394, ENST00000498815, ENST00000380384, ENST00000315377, ENST00000380381, | ENST00000281038, ENST00000528850, | |
Fusion gene scores | * DoF score | 14 X 14 X 2=392 | 20 X 8 X 9=1440 |
# samples | 18 | 20 | |
** MAII score | log2(18/392*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPS6 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS6 | GO:0031929 | TOR signaling | 16428328 |
Hgene | RPS6 | GO:0043065 | positive regulation of apoptotic process | 18362888 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ378142 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000380394 | ENST00000281038 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
5CDS-intron | ENST00000380394 | ENST00000528850 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
intron-intron | ENST00000498815 | ENST00000281038 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
intron-intron | ENST00000498815 | ENST00000528850 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
5CDS-intron | ENST00000380384 | ENST00000281038 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
5CDS-intron | ENST00000380384 | ENST00000528850 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
5CDS-intron | ENST00000315377 | ENST00000281038 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
5CDS-intron | ENST00000315377 | ENST00000528850 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
intron-intron | ENST00000380381 | ENST00000281038 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
intron-intron | ENST00000380381 | ENST00000528850 | RPS6 | chr9 | 19378367 | - | NARS2 | chr11 | 78277177 | + |
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FusionProtFeatures for RPS6_NARS2 |
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Hgene | Tgene |
RPS6 | NARS2 |
May play an important role in controlling cell growthand proliferation through the selective translation of particularclasses of mRNA. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS6_NARS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS6_NARS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPS6 | EIF3B, HSP90AA1, TERF2, POT1, DCC, STAU1, MTOR, RICTOR, MAPKAP1, RPTOR, PCK1, RAD21, NDRG1, ARRB2, SIRT7, HDAC6, TDRD3, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, RPS6KB1, RPS4X, RPL23, RPL5, RPL7, RPS3A, RPSA, RPLP0, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL27A, RPL31, RPL37A, RPL4, RPL6, RPL8, RPS12, RPS14, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS24, RPS25, RPS28, RPS3, RPS5, RPS7, RPS8, RPS2, RPS13, RPL7A, RPL3, RPL30, RPL23A, RPS26, RPS11, RPL9, RPLP1, RPLP2, RPL22, RPS9, EEF2, RPS15, RPL36, RPS17, RPL38, HSP90AB1, RPL32, RPS21, RPL17, RPS27A, RPL29, EEF1A1, FAU, NOP56, FBL, MYBBP1A, NCL, NPM1, HNRNPU, GNL3, NAP1L1, SLC25A5, ILF3, EBNA1BP2, ILF2, HNRNPA1, DHX9, NHP2L1, HNRNPM, NOP58, TUFM, NOLC1, EIF6, RPS27L, RPL10L, RPLP0P6, NOP2, NFIA, HIST1H2AD, VASN, CLINT1, NIFK, HNRNPA0, RRS1, IMPDH2, UPF1, ESR1, MAGOH, EIF4A3, SMURF1, FN1, VCAM1, UBL4A, ITGA4, VHL, PAN2, CD81, IGSF8, ICAM1, PRKACB, PLA2G12A, ATF4, PRKCSH, UPF2, FBXO6, TARDBP, PARK2, GNB2L1, PTOV1, EIF3CL, PNO1, RPS10, RPS18, RPS27, RPS29, SERBP1, SND1, WDR26, WIBG, TSR1, CEP250, TP53, TUBG1, TUBGCP3, VCP, UIMC1, MDM2, CUL7, OBSL1, EIF2A, EIF5, RPS6KB2, NTRK1, EIF5B, RPL10, RPL35, RPL3L, DDX18, PABPC1, RPL13A, RPL26, RPL26L1, RPL27, RPL28, RPL34, RPL35A, LOC101929876, SFN, FRS2, PTEN, XPO1, KIF11, CBX8, NOP9, GAN, CRY2, RC3H1, ZNF746, CNBP, KIAA0020, H2AFX, ZC3HAV1, RPF1, CYLD, TRIM25, BRCA1, LMNA, YAP1, MTF1, USP10, G3BP1, G3BP2, CAPRIN1 | NARS2 | SLC25A41, OXLD1, DARS2, ADRBK1, CHCHD2, RAB8B, PDK4, LAMP3, NDUFS7, HSPD1, ACSM5, TRNT1, CD70, YBEY, TMEM70, NIT1, GATC, CLEC2D, FOXRED1, OTC, BPNT1, CHRM3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS6_NARS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RPS6 | P62753 | DB11638 | Artenimol | 40S ribosomal protein S6 | small molecule | approved|investigational |
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RelatedDiseases for RPS6_NARS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPS6 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | RPS6 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | RPS6 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | NARS2 | C0023264 | Leigh Disease | 1 | UNIPROT |
Tgene | NARS2 | C4015643 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 24 | 1 | ORPHANET;UNIPROT |