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Fusion gene ID: 32150 |
FusionGeneSummary for RPS6KA6_HDX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS6KA6_HDX | Fusion gene ID: 32150 | Hgene | Tgene | Gene symbol | RPS6KA6 | HDX | Gene ID | 27330 | 139324 |
| Gene name | ribosomal protein S6 kinase A6 | highly divergent homeobox | |
| Synonyms | PP90RSK4|RSK-4|RSK4|S6K-alpha-6|p90RSK6 | CXorf43|D030011N01Rik | |
| Cytomap | Xq21.1 | Xq21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribosomal protein S6 kinase alpha-690 kDa ribosomal protein S6 kinase 6S6K-alpha 6p90-RSK 6ribosomal S6 kinase 4ribosomal protein S6 kinase, 90kDa, polypeptide 6 | highly divergent homeobox | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UK32 | Q7Z353 | |
| Ensembl transtripts involved in fusion gene | ENST00000262752, ENST00000543399, ENST00000495332, | ENST00000297977, ENST00000506585, ENST00000373177, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPS6KA6 [Title/Abstract] AND HDX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09Q-01A | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000262752 | ENST00000297977 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| intron-3CDS | ENST00000262752 | ENST00000506585 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| intron-3CDS | ENST00000262752 | ENST00000373177 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| In-frame | ENST00000543399 | ENST00000297977 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| In-frame | ENST00000543399 | ENST00000506585 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| In-frame | ENST00000543399 | ENST00000373177 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| intron-3CDS | ENST00000495332 | ENST00000297977 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| intron-3CDS | ENST00000495332 | ENST00000506585 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
| intron-3CDS | ENST00000495332 | ENST00000373177 | RPS6KA6 | chrX | 83441069 | - | HDX | chrX | 83588850 | - |
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FusionProtFeatures for RPS6KA6_HDX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS6KA6 | HDX |
| Constitutively active serine/threonine-protein kinasethat exhibits growth-factor-independent kinase activity and thatmay participate in p53/TP53-dependent cell growth arrest signalingand play an inhibitory role during embryogenesis.{ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS6KA6_HDX |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000297977_chrX_83588850_-_138aa MGLSTSAIWKNTRVEIVNPYEVKRKVKKIEIIDDEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQKYFKLQTFVRSLILAMKAD >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000506585_chrX_83588850_-_138aa MGLSTSAIWKNTRVEIVNPYEVKRKVKKIEIIDDEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQKYFKLQTFVRSLILAMKAD >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000373177_chrX_83588850_-_138aa MGLSTSAIWKNTRVEIVNPYEVKRKVKKIEIIDDEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQKYFKLQTFVRSLILAMKAD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000297977_chrX_83588850_-_414nt ATGGGTCTCTCTACCTCAGCAATTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAA ATTATTGATGATGAAGAAAGTGACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAA TTCATTGAAAATGAGCTCGAGATTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGAT GATAAGGAACAACAGCAGGCACTGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGAT >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000506585_chrX_83588850_-_414nt ATGGGTCTCTCTACCTCAGCAATTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAA ATTATTGATGATGAAGAAAGTGACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAA TTCATTGAAAATGAGCTCGAGATTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGAT GATAAGGAACAACAGCAGGCACTGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGAT >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000373177_chrX_83588850_-_414nt ATGGGTCTCTCTACCTCAGCAATTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAA ATTATTGATGATGAAGAAAGTGACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAA TTCATTGAAAATGAGCTCGAGATTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGAT GATAAGGAACAACAGCAGGCACTGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000297977_chrX_83588850_-_4677nt CCTGTTTGAGTGCTCCTGAAGGGGAGATGCTACCATTCGCTCCTCAGGACGAGCCCTGGGACCGAGAAATGGAAGTGTTCAGCGGCGGCG GCGCGAGCAGCGGCGAGAAAGTTGGATCCTTTTCTGATAACTTAATCGACTGCGTACTACTCCAGTAGAGGCCACCATACACCTCCTAAA AATAGTTGGTGAAATTGATTCACAGTAGGATATTTTGAGTATGTTTTAGGTATTGTAGAGATTTAACAATGGGTCTCTCTACCTCAGCAA TTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAAATTATTGATGATGAAGAAAGTG ACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAATTCATTGAAAATGAGCTCGAGA TTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGATGATAAGGAACAACAGCAGGCAC TGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGATACCTCATTCAGTGTATCTTCTT TGTCAGAGAAAAATGTCTCAGAAAGTTTGTGATTTCAGTTGGAGGGAATATATGATACAGTCTTTTGGCTTCGTAACAGGTGTGCATTTC AAGATAACTGCATTCTGTTGCCCTGGTATTCTTTAGTTGGGAAAACACATTGTTGAAACGGACGTATTCTGTGAAGAATGTACAAGATAT AATGGCTACAGTGCAACAAAAATGTAGGTGAAATTTAAAAGCATTGTTTGAGAGAGTATTTTTTTAACTGATGGAACTCTGGAAAAAAAT TATATTTAAGTTTCAGCAGTTTAACCCTGAAATTCATTATGTCTAATTTCTAACCAGAGACAAAATAACTAAAGACATTTCAGCATTGCT TATCAAGTTGCTACAGCTTGATTAGTCTTGTTTTTGTAGCCATTACATCTTCTTTCTTCTTCTCTCCTTTTCCTATCATCCACTTACACT TTTTCTCAGGAAAGTGGACTGAACATTTAAAACAAAACTTTAAAAAATTATTTAACTCATTATTTAATGAGTTCTCTGATTTAGTTTTTA ACCCCTATGAAAATTTGACTTAAACTAATGACTGAAAATTAAATGATTACAGGTATGTAATTGTAAATTGCTGGTGTTCTTCTATTATCT AACCCAAATATTTGTGTGGGGGTGGGGAAGCACAATGGAAAGGTAATTTAACCAACATAACGTCAAATAAATTACGAAGTGTACAGAAAC AAAATGTTGTCAAAATTAGTCTTGATGGGGATTCTTCATTACTACAAATGACAAGTATTGATACGATTGACATTCCAGTAGTAAATTTGT ATACCTGGGTTAGATGAAGTGTTACACAAATATTTTAAATTTATCACCATCTTTATAATTCTTTTTTAGTTCTTACATGTTATGAAACAG GAAGTCAAGGTAAGCTGCTGAGATTTTTTAAAAATTTAGTCATTCAGCTTTGCCACAAAATTTACCTCATTTCCATATGAGGCCTGTACA GAGCCATCAGCCAAGGATAGTATTCAAAAAGAGTTATACTACTTTGGTTGTAAATCACAGTCTTCTGAATTCCATGAATACTATTCTATG AGTACACACCTAAAATGGGCAAGCTACCCAGTTTTCTATTATTAGTAGGTACCAGATGGCAACACACTGTAGACTGTTCTTTGTAGTTCT TCCTTTCTGGAGTACCAGATGGTATTACCAAGACCCATAGAAGAAAAAATGTCAGTTTCTCCCTAAGCCCACAGTGTCATATATTTGTGA CTTGGCAGTGTGCAATTGTGTTGCATGGTTAAATTACTATCTATACCTAAAAGATTAATGAAGTAGCTGGATGGCTGTTTCAGCCATCAA GTTTCTGTTTCCAATTTGTTTTTAATTTTTGTTGGTACCTAGTAGGTATTCAGATATTTTTAAAAATTTGTAATTAGAGCCAAATTTGAT CTTGAAATTTACTAGTACTAACTTATGAACACAGAAAGGCAGTCATAAATGTCTTTACCCTTGAAGTGTCCCATCCTCCCACACACACAA ATAGGTAAGCTCCCACTGATAGTCTTTCATTTTGTCACTTATTTGTTTATATTGCTGCCATACTACTGATATGGTCCCTTTGTTAGTAGG AATATTTCAGTGTTCAGATATGCTTCCTTGAGCCATATGGAGTTTTGCAAACAATAGTTAGTTTTTCTTGCTGACAAGTCAAATTCCATT CAGAGAAAGCAGCAGAGAGTAACAGAGCCTCAGATATTACGATTAAATGTACCAGTCACACCAACTCCTCCATGAGATGAAGAGTCGCCC CCATATACAACGAAGTTAGAAACCACTTATTAAGTAGCATGAACAAATTCCAGGCCTTCAAGTCTCTCCTAGGGTCTGCTTCATAGTCAT TGAGTTTATCTTTCAAATATAATTACTTCTGCTTCAATTTAAGCCCCTTCTTATTTGGTTCTCATTGCAAATTAACTATAGGTATATTCT CTCCTACAGCTTTTAACACTATAGATTTTATTTGTCACGCATCAGCCATTAGTCACTAAATCGAAAAATACTTGTTGAGCTCCTGCTATA GAGAAGACACTGTGCTGGACATTGGATTTCTCAGCAAGCTGTAAACATCACAAATAATTATTTCTTTTTAACATCTTCTATGATATTAAT AAACCATATTTAAGTAGAATTTTTAATAGATTTAAGGTTCTGCTAGGTGTGATTCTTAGAAGGATTCCTAGTCCACAATTTTGAGAGAAA GCATAGATGATCTTTTTGTCTCTGTTTAACATTTCATCAAAATAGAAACTATATAAATCATAACAATACATTTAGAACTCCTTTTGTCTT GAAATTTGTGTTTCAGCACCAGAATATTTTTCTTCACCATCATTGGAATTAAAACACTTCTAAAATGAAATGTGGCTATTCTGTAGCAGG AACTGAAGGAAATACCTCTATCTATAGAAAAAGAATCATAATTGCCAGATTGAAATTATTCATGGTAGACTTTGAAAAAGATGTCAAGGT CAAGCTTTGAAAAGTTGTTATGAAGAAAGTATATTTTTTACATATGTAGATAGGAGTTGGTTTTGAGATATGTTAGAGCAGGAAAAATTA TCAGCTTATAATTACTCTTGTGGACATCTTCATGGCTGGGGATAAAAATTAACTAACTAGTGTTTCTTTCTTTAGGGCTTTGAGATTATT AAAACAGACCTTACTATCTGAAGGCTCTCTCAGGGAGACAGAAGCCAATGTGGAAAAAAACAAAAAACAAAAAACAACAACAAGAAAAAA CTTCTTTTTTTCTTTCAACTACATTTCTATGTCTGCTTTAAGCTTAGAACAGCCAAGCAGTTTTTAAGCCAGAAATGTGTATGTAAGAGC ACTTACCTTCCAAAATGTGTACATATGAAAAAAAAAGGAAGGTATTTTCTTCTTTTCAGCCAAGCTAAACTTATTCACAAGAAAATGAGA ATTGCAATTGCTCTGGAGAATAGGAAAATTAGCACATGCAAAGAAAACCTTAAAAGAAAATTGGCCTCTTCATGGAAACTGGGGATGTTT TGTCCTAAGGTCAGTTATCAACAGCAGGATTTTTGTATTGCCATTGCAAGCATGTGATAGAAATGTTTGTTATTGTTGGAGAAGAAAAGG CTGAGACCCAATTATACCCTGTACTCTTTATTCGACCAAGACCTCAAAAGATGTCAAAGAAGCCATTTCTCCAAAGACAGCAACATCTAT TGTGAGGCACTTTCATATTCAGCAGTCTGTAAGTTTGTAGGAGAAAACATAAGTGGTTAATTTAAAATAATTTTGGGCTCTAAAATGGAC TTTGTTGCCTTTTTTGGTGGGGGTGGTGGGAATCGGATTCAGCCCATTTCCAAGGGATAGTTTCTTCATCTCAGACAACTATTTTGTGAT CCTTTTTAAAAGACATTCTGAAAACTTTAACTCCTGCCCTTCTTCCGTATTACAGTTGTGTTATTCCAGAAATATTGTCTACTTTTTTAA TATATTAGATTTTCATTCAGATCTTAAACATGCAAACATGTGATAGGTTAGCTTTTTAAGGGAGTTATCAGTACCACTGTATCTAAATGT TAGGTAAATGGGTAGATTTCTCTTTGAAGTTGGTATTTTCCTTGGCAGACAGCACTGTATCATGCTCTTCACCAAGCTATGCTCTGTAAT GCTATAATCAAGGAGGCTACTAACTTGTGAACCTACAGTCAACACACCATTGCTGAAAACAAACTTTGATTAAGAACAGATTTGCTAGGG GGAAAAAAGAGTAAAGTGATATTTTCAAGCAAATATAATTAAAATTGTTTCATTAAAATATATACTGAGTGTATATTGCTCCACACTGAA ATTTTATTTTGCATTAACTTGTTAAGTAATTCATTTTAGCAATCCTGCATCCCATTTTACTAGTACTACCTCTGAAATATACTGTCACCT >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000506585_chrX_83588850_-_4673nt CCTGTTTGAGTGCTCCTGAAGGGGAGATGCTACCATTCGCTCCTCAGGACGAGCCCTGGGACCGAGAAATGGAAGTGTTCAGCGGCGGCG GCGCGAGCAGCGGCGAGAAAGTTGGATCCTTTTCTGATAACTTAATCGACTGCGTACTACTCCAGTAGAGGCCACCATACACCTCCTAAA AATAGTTGGTGAAATTGATTCACAGTAGGATATTTTGAGTATGTTTTAGGTATTGTAGAGATTTAACAATGGGTCTCTCTACCTCAGCAA TTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAAATTATTGATGATGAAGAAAGTG ACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAATTCATTGAAAATGAGCTCGAGA TTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGATGATAAGGAACAACAGCAGGCAC TGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGATACCTCATTCAGTGTATCTTCTT TGTCAGAGAAAAATGTCTCAGAAAGTTTGTGATTTCAGTTGGAGGGAATATATGATACAGTCTTTTGGCTTCGTAACAGGTGTGCATTTC AAGATAACTGCATTCTGTTGCCCTGGTATTCTTTAGTTGGGAAAACACATTGTTGAAACGGACGTATTCTGTGAAGAATGTACAAGATAT AATGGCTACAGTGCAACAAAAATGTAGGTGAAATTTAAAAGCATTGTTTGAGAGAGTATTTTTTTAACTGATGGAACTCTGGAAAAAAAT TATATTTAAGTTTCAGCAGTTTAACCCTGAAATTCATTATGTCTAATTTCTAACCAGAGACAAAATAACTAAAGACATTTCAGCATTGCT TATCAAGTTGCTACAGCTTGATTAGTCTTGTTTTTGTAGCCATTACATCTTCTTTCTTCTTCTCTCCTTTTCCTATCATCCACTTACACT TTTTCTCAGGAAAGTGGACTGAACATTTAAAACAAAACTTTAAAAAATTATTTAACTCATTATTTAATGAGTTCTCTGATTTAGTTTTTA ACCCCTATGAAAATTTGACTTAAACTAATGACTGAAAATTAAATGATTACAGGTATGTAATTGTAAATTGCTGGTGTTCTTCTATTATCT AACCCAAATATTTGTGTGGGGGTGGGGAAGCACAATGGAAAGGTAATTTAACCAACATAACGTCAAATAAATTACGAAGTGTACAGAAAC AAAATGTTGTCAAAATTAGTCTTGATGGGGATTCTTCATTACTACAAATGACAAGTATTGATACGATTGACATTCCAGTAGTAAATTTGT ATACCTGGGTTAGATGAAGTGTTACACAAATATTTTAAATTTATCACCATCTTTATAATTCTTTTTTAGTTCTTACATGTTATGAAACAG GAAGTCAAGGTAAGCTGCTGAGATTTTTTAAAAATTTAGTCATTCAGCTTTGCCACAAAATTTACCTCATTTCCATATGAGGCCTGTACA GAGCCATCAGCCAAGGATAGTATTCAAAAAGAGTTATACTACTTTGGTTGTAAATCACAGTCTTCTGAATTCCATGAATACTATTCTATG AGTACACACCTAAAATGGGCAAGCTACCCAGTTTTCTATTATTAGTAGGTACCAGATGGCAACACACTGTAGACTGTTCTTTGTAGTTCT TCCTTTCTGGAGTACCAGATGGTATTACCAAGACCCATAGAAGAAAAAATGTCAGTTTCTCCCTAAGCCCACAGTGTCATATATTTGTGA CTTGGCAGTGTGCAATTGTGTTGCATGGTTAAATTACTATCTATACCTAAAAGATTAATGAAGTAGCTGGATGGCTGTTTCAGCCATCAA GTTTCTGTTTCCAATTTGTTTTTAATTTTTGTTGGTACCTAGTAGGTATTCAGATATTTTTAAAAATTTGTAATTAGAGCCAAATTTGAT CTTGAAATTTACTAGTACTAACTTATGAACACAGAAAGGCAGTCATAAATGTCTTTACCCTTGAAGTGTCCCATCCTCCCACACACACAA ATAGGTAAGCTCCCACTGATAGTCTTTCATTTTGTCACTTATTTGTTTATATTGCTGCCATACTACTGATATGGTCCCTTTGTTAGTAGG AATATTTCAGTGTTCAGATATGCTTCCTTGAGCCATATGGAGTTTTGCAAACAATAGTTAGTTTTTCTTGCTGACAAGTCAAATTCCATT CAGAGAAAGCAGCAGAGAGTAACAGAGCCTCAGATATTACGATTAAATGTACCAGTCACACCAACTCCTCCATGAGATGAAGAGTCGCCC CCATATACAACGAAGTTAGAAACCACTTATTAAGTAGCATGAACAAATTCCAGGCCTTCAAGTCTCTCCTAGGGTCTGCTTCATAGTCAT TGAGTTTATCTTTCAAATATAATTACTTCTGCTTCAATTTAAGCCCCTTCTTATTTGGTTCTCATTGCAAATTAACTATAGGTATATTCT CTCCTACAGCTTTTAACACTATAGATTTTATTTGTCACGCATCAGCCATTAGTCACTAAATCGAAAAATACTTGTTGAGCTCCTGCTATA GAGAAGACACTGTGCTGGACATTGGATTTCTCAGCAAGCTGTAAACATCACAAATAATTATTTCTTTTTAACATCTTCTATGATATTAAT AAACCATATTTAAGTAGAATTTTTAATAGATTTAAGGTTCTGCTAGGTGTGATTCTTAGAAGGATTCCTAGTCCACAATTTTGAGAGAAA GCATAGATGATCTTTTTGTCTCTGTTTAACATTTCATCAAAATAGAAACTATATAAATCATAACAATACATTTAGAACTCCTTTTGTCTT GAAATTTGTGTTTCAGCACCAGAATATTTTTCTTCACCATCATTGGAATTAAAACACTTCTAAAATGAAATGTGGCTATTCTGTAGCAGG AACTGAAGGAAATACCTCTATCTATAGAAAAAGAATCATAATTGCCAGATTGAAATTATTCATGGTAGACTTTGAAAAAGATGTCAAGGT CAAGCTTTGAAAAGTTGTTATGAAGAAAGTATATTTTTTACATATGTAGATAGGAGTTGGTTTTGAGATATGTTAGAGCAGGAAAAATTA TCAGCTTATAATTACTCTTGTGGACATCTTCATGGCTGGGGATAAAAATTAACTAACTAGTGTTTCTTTCTTTAGGGCTTTGAGATTATT AAAACAGACCTTACTATCTGAAGGCTCTCTCAGGGAGACAGAAGCCAATGTGGAAAAAAACAAAAAACAAAAAACAACAACAAGAAAAAA CTTCTTTTTTTCTTTCAACTACATTTCTATGTCTGCTTTAAGCTTAGAACAGCCAAGCAGTTTTTAAGCCAGAAATGTGTATGTAAGAGC ACTTACCTTCCAAAATGTGTACATATGAAAAAAAAAGGAAGGTATTTTCTTCTTTTCAGCCAAGCTAAACTTATTCACAAGAAAATGAGA ATTGCAATTGCTCTGGAGAATAGGAAAATTAGCACATGCAAAGAAAACCTTAAAAGAAAATTGGCCTCTTCATGGAAACTGGGGATGTTT TGTCCTAAGGTCAGTTATCAACAGCAGGATTTTTGTATTGCCATTGCAAGCATGTGATAGAAATGTTTGTTATTGTTGGAGAAGAAAAGG CTGAGACCCAATTATACCCTGTACTCTTTATTCGACCAAGACCTCAAAAGATGTCAAAGAAGCCATTTCTCCAAAGACAGCAACATCTAT TGTGAGGCACTTTCATATTCAGCAGTCTGTAAGTTTGTAGGAGAAAACATAAGTGGTTAATTTAAAATAATTTTGGGCTCTAAAATGGAC TTTGTTGCCTTTTTTGGTGGGGGTGGTGGGAATCGGATTCAGCCCATTTCCAAGGGATAGTTTCTTCATCTCAGACAACTATTTTGTGAT CCTTTTTAAAAGACATTCTGAAAACTTTAACTCCTGCCCTTCTTCCGTATTACAGTTGTGTTATTCCAGAAATATTGTCTACTTTTTTAA TATATTAGATTTTCATTCAGATCTTAAACATGCAAACATGTGATAGGTTAGCTTTTTAAGGGAGTTATCAGTACCACTGTATCTAAATGT TAGGTAAATGGGTAGATTTCTCTTTGAAGTTGGTATTTTCCTTGGCAGACAGCACTGTATCATGCTCTTCACCAAGCTATGCTCTGTAAT GCTATAATCAAGGAGGCTACTAACTTGTGAACCTACAGTCAACACACCATTGCTGAAAACAAACTTTGATTAAGAACAGATTTGCTAGGG GGAAAAAAGAGTAAAGTGATATTTTCAAGCAAATATAATTAAAATTGTTTCATTAAAATATATACTGAGTGTATATTGCTCCACACTGAA ATTTTATTTTGCATTAACTTGTTAAGTAATTCATTTTAGCAATCCTGCATCCCATTTTACTAGTACTACCTCTGAAATATACTGTCACCT >In-frame_RPS6KA6_ENST00000543399_chrX_83441069_-_HDX_ENST00000373177_chrX_83588850_-_1354nt CCTGTTTGAGTGCTCCTGAAGGGGAGATGCTACCATTCGCTCCTCAGGACGAGCCCTGGGACCGAGAAATGGAAGTGTTCAGCGGCGGCG GCGCGAGCAGCGGCGAGAAAGTTGGATCCTTTTCTGATAACTTAATCGACTGCGTACTACTCCAGTAGAGGCCACCATACACCTCCTAAA AATAGTTGGTGAAATTGATTCACAGTAGGATATTTTGAGTATGTTTTAGGTATTGTAGAGATTTAACAATGGGTCTCTCTACCTCAGCAA TTTGGAAAAATACTCGAGTGGAAATTGTTAATCCCTATGAAGTAAAACGAAAGGTGAAGAAAATAGAAATTATTGATGATGAAGAAAGTG ACATGATAAGTAATTCTGAAGTAGAACAAGTAAACTCTTTCTTGGATTATAAGAATGAAGAAGTCAAATTCATTGAAAATGAGCTCGAGA TTCAAAAGCAAAAATACTTTAAACTTCAGACTTTTGTTAGAAGCTTGATATTAGCAATGAAAGCTGATGATAAGGAACAACAGCAGGCAC TGCTGTCAGATTTACCTCCTGAATTAGAGGAAATGGATTTCAATCATGCCTCACTGGAGCCTGATGATACCTCATTCAGTGTATCTTCTT TGTCAGAGAAAAATGTCTCAGAAAGTTTGTGATTTCAGTTGGAGGGAATATATGATACAGTCTTTTGGCTTCGTAACAGGTGTGCATTTC AAGATAACTGCATTCTGTTGCCCTGGTATTCTTTAGTTGGGAAAACACATTGTTGAAACGGACGTATTCTGTGAAGAATGTACAAGATAT AATGGCTACAGTGCAACAAAAATGTAGGTGAAATTTAAAAGCATTGTTTGAGAGAGTATTTTTTTAACTGATGGAACTCTGGAAAAAAAT TATATTTAAGTTTCAGCAGTTTAACCCTGAAATTCATTATGTCTAATTTCTAACCAGAGACAAAATAACTAAAGACATTTCAGCATTGCT TATCAAGTTGCTACAGCTTGATTAGTCTTGTTTTTGTAGCCATTACATCTTCTTTCTTCTTCTCTCCTTTTCCTATCATCCACTTACACT TTTTCTCAGGAAAGTGGACTGAACATTTAAAACAAAACTTTAAAAAATTATTTAACTCATTATTTAATGAGTTCTCTGATTTAGTTTTTA ACCCCTATGAAAATTTGACTTAAACTAATGACTGAAAATTAAATGATTACAGGTATGTAATTGTAAATTGCTGGTGTTCTTCTATTATCT AACCCAAATATTTGTGTGGGGGTGGGGAAGCACAATGGAAAGGTAATTTAACCAACATAACGTCAAATAAATTACGAAGTGTACAGAAAC |
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FusionGenePPI for RPS6KA6_HDX |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RPS6KA6 | NR4A1, MICAL1, MPP1, RXRA, DHX34, CENPB, ADIRF, ZNF227, SYNE4, UFM1, SPTBN4, SAP30BP, FBN3, DNAJC13, C14orf1, LMO4, CEBPZ, ZNF746, RPLP1, MED24, RBPJ, DNMT1, CLEC3B, MASP1, MAPK3, FZD5, UBE2I, APP, NFYA, PQBP1, UBAC1, SLC9A1, MBP, CDC37, HSP90AA1, OSGIN1 | HDX | ZBTB16, SUFU, YWHAE, NANOG, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS6KA6_HDX |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS6KA6_HDX |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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