FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32138

FusionGeneSummary for RPS6KA3_IRF3

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA3_IRF3
Fusion gene ID: 32138
HgeneTgene
Gene symbol

RPS6KA3

IRF3

Gene ID

6197

3661

Gene nameribosomal protein S6 kinase A3interferon regulatory factor 3
SynonymsCLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2IIAE7
Cytomap

Xp22.12

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3insulin-stimulated protein kinase 1p90-RSK 3ribosomal S6 kinase 2ribosomal protein S6 kinase, 90kDinterferon regulatory factor 3
Modification date2018052320180527
UniProtAcc

P51812

Q14653

Ensembl transtripts involved in fusion geneENST00000379565, ENST00000544447, 
ENST00000379548, ENST00000540702, 
ENST00000479809, 
ENST00000599680, 
ENST00000309877, ENST00000600911, 
ENST00000596822, ENST00000601291, 
ENST00000377139, ENST00000597198, 
ENST00000593922, ENST00000600022, 
ENST00000599223, ENST00000596765, 
ENST00000599144, ENST00000598808, 
ENST00000377135, ENST00000442265, 
Fusion gene scores* DoF score7 X 4 X 5=1406 X 5 X 4=120
# samples 76
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KA3 [Title/Abstract] AND IRF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA3

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937

TgeneIRF3

GO:0045944

positive regulation of transcription by RNA polymerase II

9660935


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW297289RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379565ENST00000599680RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000309877RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000600911RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000596822RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000601291RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000377139RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000597198RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000593922RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000600022RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000599223RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000596765RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000599144RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000598808RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000377135RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379565ENST00000442265RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000599680RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000309877RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000600911RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000596822RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000601291RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000377139RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000597198RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000593922RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000600022RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000599223RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000596765RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000599144RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000598808RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000377135RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000544447ENST00000442265RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000599680RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000309877RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000600911RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000596822RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000601291RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000377139RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000597198RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000593922RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000600022RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000599223RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000596765RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000599144RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000598808RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000377135RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000379548ENST00000442265RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000599680RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000309877RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000600911RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000596822RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000601291RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000377139RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000597198RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000593922RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000600022RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000599223RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000596765RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000599144RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000598808RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000377135RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000540702ENST00000442265RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000599680RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000309877RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000600911RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000596822RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000601291RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000377139RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000597198RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000593922RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000600022RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000599223RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000596765RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000599144RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000598808RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000377135RPS6KA3chrX

20273653

+IRF3chr19

50165136

+
intron-intronENST00000479809ENST00000442265RPS6KA3chrX

20273653

+IRF3chr19

50165136

+

Top

FusionProtFeatures for RPS6KA3_IRF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6KA3

P51812

IRF3

Q14653

Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of the transcription factors CREB1,ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 andEIF4B phosphorylation, and mediates cellular proliferation,survival, and differentiation by modulating mTOR signaling andrepressing pro-apoptotic function of BAD and DAPK1. In fibroblast,is required for EGF-stimulated phosphorylation of CREB1 andhistone H3 at 'Ser-10', which results in the subsequenttranscriptional activation of several immediate-early genes. Inresponse to mitogenic stimulation (EGF and PMA), phosphorylatesand activates NR4A1/NUR77 and ETV1/ER81 transcription factors andthe cofactor CREBBP. Upon insulin-derived signal, acts indirectlyon the transcription regulation of several genes byphosphorylating GSK3B at 'Ser-9' and inhibiting its activity.Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation byfacilitating assembly of the preinitiation complex. In response toinsulin, phosphorylates EIF4B, enhancing EIF4B affinity for theEIF3 complex and stimulating cap-dependent translation. Isinvolved in the mTOR nutrient-sensing pathway by directlyphosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2ability to suppress mTOR signaling, and mediates phosphorylationof RPTOR, which regulates mTORC1 activity and may promoterapamycin-sensitive signaling independently of the PI3K/AKTpathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellatecells by phosphorylating CEBPB in response to the hepatotoxincarbon tetrachloride (CCl4). Is involved in cell cycle regulationby phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1Bassociation with 14-3-3 proteins and prevents its translocation tothe nucleus and inhibition of G1 progression. In LPS-stimulateddendritic cells, is involved in TLR4-induced macropinocytosis, andin myeloma cells, acts as effector of FGFR3-mediatedtransformation signaling, after direct phosphorylation at Tyr-529by FGFR3. Negatively regulates EGF-induced MAPK1/3 phosphorylationvia phosphorylation of SOS1. Phosphorylates SOS1 at 'Ser-1134' and'Ser-1161' that create YWHAB and YWHAE binding sites and whichcontribute to the negative regulation of MAPK1/3 phosphorylation(By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).{ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156,ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362,ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121,ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835,ECO:0000269|PubMed:9770464}. Key transcriptional regulator of type I interferon(IFN)-dependent immune responses which plays a critical role inthe innate immune response against DNA and RNA viruses. Regulatesthe transcription of type I IFN genes (IFN-alpha and IFN-beta) andIFN-stimulated genes (ISG) by binding to an interferon-stimulatedresponse element (ISRE) in their promoters. Acts as a more potentactivator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA)gene and plays a critical role in both the early and late phasesof the IFNA/B gene induction. Found in an inactive form in thecytoplasm of uninfected cells and following viral infection,double-stranded RNA (dsRNA), or toll-like receptor (TLR)signaling, is phosphorylated by IKBKE and TBK1 kinases. Thisinduces a conformational change, leading to its dimerization andnuclear localization and association with CREB binding protein(CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex whichactivates the transcription of the type I IFN and ISG genes. Canactivate distinct gene expression programs in macrophages and caninduce significant apoptosis in primary macrophages.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPS6KA3_IRF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPS6KA3_IRF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPS6KA3_IRF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS6KA3P51812DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3small moleculeapproved|vet_approved

Top

RelatedDiseases for RPS6KA3_IRF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS6KA3C0265252Coffin-Lowry syndrome6CTD_human;ORPHANET;UNIPROT
HgeneRPS6KA3C0796225Mental Retardation, X-Linked 192UNIPROT
HgeneRPS6KA3C0005941Bone Diseases, Developmental1CTD_human
HgeneRPS6KA3C0027626Neoplasm Invasiveness1CTD_human
HgeneRPS6KA3C0027627Neoplasm Metastasis1CTD_human
HgeneRPS6KA3C0033922Psychomotor Disorders1CTD_human
HgeneRPS6KA3C2239176Liver carcinoma1CTD_human
TgeneIRF3C4225294HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 71UNIPROT