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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32133

FusionGeneSummary for RPS6KA2_RPS6KA2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA2_RPS6KA2
Fusion gene ID: 32133
HgeneTgene
Gene symbol

RPS6KA2

RPS6KA2

Gene ID

6196

6196

Gene nameribosomal protein S6 kinase A2ribosomal protein S6 kinase A2
SynonymsHU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3HU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3
Cytomap

6q27

6q27

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptideribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptide
Modification date2018052320180523
UniProtAcc

Q15349

Q15349

Ensembl transtripts involved in fusion geneENST00000265678, ENST00000510118, 
ENST00000503859, ENST00000481261, 
ENST00000405189, ENST00000366863, 
ENST00000509742, 
ENST00000265678, 
ENST00000510118, ENST00000503859, 
ENST00000481261, ENST00000405189, 
ENST00000366863, ENST00000509742, 
Fusion gene scores* DoF score6 X 5 X 4=1203 X 3 X 1=9
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS6KA2 [Title/Abstract] AND RPS6KA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

HgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

HgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154

TgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

TgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

TgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI011349RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000265678ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000265678ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000265678ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000265678ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000265678ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000265678ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000265678ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000510118ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000510118ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000510118ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000510118ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000510118ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000510118ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000510118ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000503859ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000503859ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000503859ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000503859ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000503859ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000503859ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000503859ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000481261ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000481261ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000481261ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000481261ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000481261ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000481261ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000481261ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000405189ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000405189ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000405189ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000405189ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000405189ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000405189ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000405189ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000366863ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000366863ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000366863ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000366863ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000366863ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000366863ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000366863ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000509742ENST00000265678RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000509742ENST00000510118RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000509742ENST00000503859RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000509742ENST00000481261RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-3CDSENST00000509742ENST00000405189RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000509742ENST00000366863RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-
intron-intronENST00000509742ENST00000509742RPS6KA2chr6

166843955

+RPS6KA2chr6

166844073

-

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FusionProtFeatures for RPS6KA2_RPS6KA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6KA2

Q15349

RPS6KA2

Q15349

Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. {ECO:0000269|PubMed:16878154,ECO:0000269|PubMed:7623830}. Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. {ECO:0000269|PubMed:16878154,ECO:0000269|PubMed:7623830}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS6KA2_RPS6KA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS6KA2_RPS6KA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS6KA2_RPS6KA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS6KA2_RPS6KA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource