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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32115

FusionGeneSummary for RPS4X_SUPT5H

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS4X_SUPT5H
Fusion gene ID: 32115
HgeneTgene
Gene symbol

RPS4X

SUPT5H

Gene ID

6191

6829

Gene nameribosomal protein S4 X-linkedSPT5 homolog, DSIF elongation factor subunit
SynonymsCCG2|DXS306|RPS4|S4|SCAR|SCR10SPT5|SPT5H|Tat-CT1
Cytomap

Xq13.1

19q13.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S4, X isoformcell cycle gene 2ribosomal protein S4X isoformsingle copy abundant mRNA proteinsingle-copy abundant mRNAsmall ribosomal subunit protein eS4transcription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homolog
Modification date2018052320180523
UniProtAcc

P62701

O00267

Ensembl transtripts involved in fusion geneENST00000316084, ENST00000486733, 
ENST00000373626, 
ENST00000599117, 
ENST00000432763, ENST00000402194, 
ENST00000359191, ENST00000598725, 
Fusion gene scores* DoF score6 X 7 X 2=847 X 6 X 4=168
# samples 77
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS4X [Title/Abstract] AND SUPT5H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

TgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

TgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW015878RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000316084ENST00000599117RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000316084ENST00000432763RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000316084ENST00000402194RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000316084ENST00000359191RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000316084ENST00000598725RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000486733ENST00000599117RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000486733ENST00000432763RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000486733ENST00000402194RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000486733ENST00000359191RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000486733ENST00000598725RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000373626ENST00000599117RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000373626ENST00000432763RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000373626ENST00000402194RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000373626ENST00000359191RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-
intron-3CDSENST00000373626ENST00000598725RPS4XchrX

71492541

+SUPT5Hchr19

39963718

-

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FusionProtFeatures for RPS4X_SUPT5H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS4X

P62701

SUPT5H

O00267

Component of the DRB sensitivity-inducing factor complex(DSIF complex), which regulates mRNA processing and transcriptionelongation by RNA polymerase II. DSIF positively regulates mRNAcapping by stimulating the mRNA guanylyltransferase activity ofRNGTT/CAP1A. DSIF also acts cooperatively with the negativeelongation factor complex (NELF complex) to enhancetranscriptional pausing at sites proximal to the promoter.Transcriptional pausing may facilitate the assembly of anelongation competent RNA polymerase II complex. DSIF and NELFpromote pausing by inhibition of the transcription elongationfactor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II attranscription pause sites and stimulates the weak intrinsicnuclease activity of the enzyme. Cleavage of blocked transcriptsby RNA polymerase II promotes the resumption of transcription fromthe new 3' terminus and may allow repeated attempts attranscription through natural pause sites. DSIF can alsopositively regulate transcriptional elongation and is required forthe efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppresstranscriptional pausing in transcripts derived from the HIV-1 LTRand blocks premature release of HIV-1 transcripts at terminatorsequences. {ECO:0000269|PubMed:10075709,ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184,ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543,ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615,ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964,ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750,ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072,ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929,ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS4X_SUPT5H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS4X_SUPT5H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS4X_SUPT5H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS4X_SUPT5H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS4XC1458155Mammary Neoplasms1CTD_human