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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32102

FusionGeneSummary for RPS27L_CSDE1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS27L_CSDE1
Fusion gene ID: 32102
HgeneTgene
Gene symbol

RPS27L

CSDE1

Gene ID

51065

7812

Gene nameribosomal protein S27 likecold shock domain containing E1
Synonyms-D1S155E|UNR
Cytomap

15q22.2

1p13.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S27-likesmall ribosomal subunit protein eS27-likecold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS
Modification date2018052320180519
UniProtAcc

Q71UM5

O75534

Ensembl transtripts involved in fusion geneENST00000559763, ENST00000330964, 
ENST00000462430, ENST00000455271, 
ENST00000411926, ENST00000439025, 
ENST00000339438, ENST00000438362, 
ENST00000358528, ENST00000261443, 
ENST00000530886, ENST00000369530, 
ENST00000483407, ENST00000534699, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 7 X 3=147
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS27L [Title/Abstract] AND CSDE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS27L

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17057733

HgeneRPS27L

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

18056458

HgeneRPS27L

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17057733|18056458

HgeneRPS27L

GO:0045727

positive regulation of translation

18056458


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF978658RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000559763ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000559763ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000559763ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000330964ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000330964ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000462430ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000462430ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000455271ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000455271ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000411926ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000411926ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000339438RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000438362RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000358528RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000261443RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000530886RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000369530RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-5UTRENST00000439025ENST00000483407RPS27Lchr15

63448638

-CSDE1chr1

115260758

-
intron-3UTRENST00000439025ENST00000534699RPS27Lchr15

63448638

-CSDE1chr1

115260758

-

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FusionProtFeatures for RPS27L_CSDE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS27L

Q71UM5

CSDE1

O75534


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS27L_CSDE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS27L_CSDE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS27L_CSDE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS27L_CSDE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource