|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32098 |
FusionGeneSummary for RPS25_STK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS25_STK4 | Fusion gene ID: 32098 | Hgene | Tgene | Gene symbol | RPS25 | STK4 | Gene ID | 6230 | 6789 |
| Gene name | ribosomal protein S25 | serine/threonine kinase 4 | |
| Synonyms | S25 | KRS2|MST1|YSK3 | |
| Cytomap | 11q23.3 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 40S ribosomal protein S25small ribosomal subunit protein eS25 | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P62851 | Q13043 | |
| Ensembl transtripts involved in fusion gene | ENST00000527673, ENST00000528547, | ENST00000372806, ENST00000396731, ENST00000372801, ENST00000499879, ENST00000487587, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPS25 [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK4 | GO:0000902 | cell morphogenesis | 11805089 |
| Tgene | STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
| Tgene | STK4 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
| Tgene | STK4 | GO:0006915 | apoptotic process | 21212262 |
| Tgene | STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
| Tgene | STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
| Tgene | STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
| Tgene | STK4 | GO:0035329 | hippo signaling | 20412773 |
| Tgene | STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
| Tgene | STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
| Tgene | STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
| Tgene | STK4 | GO:0050821 | protein stabilization | 19962960 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP271042 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000527673 | ENST00000372806 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000396731 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000372801 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000499879 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000487587 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-3UTR | ENST00000528547 | ENST00000372806 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000396731 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000372801 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000499879 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000487587 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
Top |
FusionProtFeatures for RPS25_STK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS25 | STK4 |
| Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation (Bysimilarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph)during apoptosis. Phosphorylates FOXO3 upon oxidative stress,which results in its nuclear translocation and cell deathinitiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2.Phosphorylates TNNI3 (cardiac Tn-I) and alters its bindingaffinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).Phosphorylates FOXO1 on 'Ser-212' and regulates its activation andstimulates transcription of PMAIP1 in a FOXO1-dependent manner.Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53deacetylation, thereby promoting p53/TP53 dependent transcriptionand apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1.Phosphorylates AR on 'Ser-650' and suppresses its activity byintersecting with PKB/AKT1 signaling and antagonizing formation ofAR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11,ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310,ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305,ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106,ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262,ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132,ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RPS25_STK4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RPS25_STK4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RPS25_STK4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RPS25_STK4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|