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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32091

FusionGeneSummary for RPS24_CLASP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS24_CLASP1
Fusion gene ID: 32091
HgeneTgene
Gene symbol

RPS24

CLASP1

Gene ID

6229

23332

Gene nameribosomal protein S24cytoplasmic linker associated protein 1
SynonymsDBA3|S24|eS24MAST1
Cytomap

10q22.3

2q14.2-q14.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S24small ribosomal subunit protein eS24CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1
Modification date2018052220180522
UniProtAcc

P62847

Q7Z460

Ensembl transtripts involved in fusion geneENST00000435275, ENST00000440692, 
ENST00000372360, ENST00000476545, 
ENST00000360830, 		ENST00000409078, 
ENST00000541859, ENST00000541377, 
ENST00000455322, ENST00000397587, 
ENST00000263710, ENST00000545861, 
ENST00000430234, 
Fusion gene scores* DoF score7 X 7 X 1=495 X 5 X 3=75
# samples 96
** MAII scorelog2(9/49*10)=0.877143252214467
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS24 [Title/Abstract] AND CLASP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLASP1

GO:0051294

establishment of spindle orientation

21822276

TgeneCLASP1

GO:0051301

cell division

21822276


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ027949RPS24chr10

79795400

-CLASP1chr2

122122756

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000435275ENST00000409078RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000541859RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000541377RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000455322RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000397587RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000263710RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000435275ENST00000545861RPS24chr10

79795400

-CLASP1chr2

122122756

+
5CDS-intronENST00000435275ENST00000430234RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000409078RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000541859RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000541377RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000455322RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000397587RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000263710RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000440692ENST00000545861RPS24chr10

79795400

-CLASP1chr2

122122756

+
5CDS-intronENST00000440692ENST00000430234RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000409078RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000541859RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000541377RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000455322RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000397587RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000263710RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000372360ENST00000545861RPS24chr10

79795400

-CLASP1chr2

122122756

+
5CDS-intronENST00000372360ENST00000430234RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000409078RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000541859RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000541377RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000455322RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000397587RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000263710RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-3CDSENST00000476545ENST00000545861RPS24chr10

79795400

-CLASP1chr2

122122756

+
3UTR-intronENST00000476545ENST00000430234RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000409078RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000541859RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000541377RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000455322RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000397587RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000263710RPS24chr10

79795400

-CLASP1chr2

122122756

+
Frame-shiftENST00000360830ENST00000545861RPS24chr10

79795400

-CLASP1chr2

122122756

+
5CDS-intronENST00000360830ENST00000430234RPS24chr10

79795400

-CLASP1chr2

122122756

+

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FusionProtFeatures for RPS24_CLASP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS24

P62847

CLASP1

Q7Z460

Required for processing of pre-rRNA and maturation of40S ribosomal subunits. {ECO:0000269|PubMed:18230666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS24_CLASP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS24_CLASP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS24_CLASP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS24_CLASP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource